Major Depressive Disorder News and Research

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Major Depressive Disorder (MDD) is a psychiatric condition characterized by depressed mood or anhedonia (significant loss of interest or pleasure). The condition affects more than 15.7 million adults and approximately 3 million adolescents (aged 13 to 17 years) in the USA each year.

Saliva test could be used for lithium monitoring among patients with mood disorders

Lithium is a common medication prescribed to patients with psychiatric disorders, namely bipolar disorder, schizophrenia, and depression.

4 Oct 2021

Scientists link insulin resistance to increased risk of developing major depressive disorder

Stanford Medicine scientists have linked insulin resistance to an increased risk of developing a major depressive disorder.

29 Sep 2021

Insulin resistance linked to an increased risk of major depressive disorder

Stanford Medicine scientists have linked insulin resistance to an increased risk of developing major depressive disorder.

23 Sep 2021

Study finds cognitive safety of ketamine and esketamine for patients with treatment-resistant depression

Used for the treatment of depression that does not respond to standard antidepressant medications, the anesthesia drug ketamine – and the related drug esketamine, recently approved for depression treatment – has no important adverse effects on memory, attention, or other cognitive processes, concludes a systematic review of medical research in the September/October issue of Harvard Review of Psychiatry.

12 Aug 2021

Canadians with a history of drug dependence more likely to have mental illness, finds study

New research published online in the International Journal of Mental Health and Addiction found that Canadians with a history of drug dependence are much less likely to have flourishing mental health and are more likely to have mental illness.

14 Jul 2021

Study: 57.8% of healthcare professionals suffered mental disorders during COVID-19 first wave

A study on 149 healthcare professionals in Spain and Mexico reveals that, during the first wave of the COVID-19 pandemic, 57.8% of them suffered from mental disorders such as anxiety, acute stress and depression.

12 Jul 2021

Many coal miners suffering from black lung disease struggle with mental-health issues

More than a third of coal miners and former coal miners suffering from black lung disease struggle with depression, and more than one in 10 has recently considered suicide, a new study finds.

8 Jul 2021

New project aims to identify quantitative biological features common across diseases

Building on the success of innovative research by the PRISM project, the Innovative Medicine Initiative 2, a joint undertaking between the EU and the European Federation of Pharmaceutical Industries and Associations (EFPIA), has backed the program with funding for a new project to explore the underlying biology of Alzheimer's disease, schizophrenia and Major Depressive Disorder (MDD).

23 Jun 2021

Study reveals the interplay between proteins that control the body's stress response

The biological mechanisms behind stress-related psychiatric conditions, including major depressive disorder and post-traumatic stress disorder (PTSD), are poorly understood.

21 Jun 2021

UIC discovery may lead to new treatments for alcohol use disorder and depression

A discovery from researchers at the University of Illinois Chicago may lead to new treatments for individuals who suffer from alcohol use disorder and depression.

14 Jun 2021

Waking up just one hour earlier can reduce risk of major depression, indicates study

Waking up just one hour earlier could reduce a person's risk of major depression by 23%, suggests a sweeping new genetic study published May 26 in the journal JAMA Psychiatry.

29 May 2021

Genomic study identifies marked differences between two halves of the hippocampus

A study of gene activity in the brain's hippocampus, led by UT Southwestern researchers, has identified marked differences between the region's anterior and posterior portions. The findings, published today in Neuron, could shed light on a variety of brain disorders that involve the hippocampus and may eventually help lead to new, targeted treatments.

29 May 2021

Scientists identify many new gene variants that increase risk for depression

In the largest genetic analysis of depression to date, Veterans Affairs researchers identified many new gene variants that increase the risk for depression. The groundbreaking study helps researchers better understand the biological basis of depression and could lead to better drug treatments.

28 May 2021

Smart device-based electronic platform can continuously monitor mental health

To help patients manage their mental wellness between appointments, researchers at Texas A&M University have developed a smart device-based electronic platform that can continuously monitor the state of hyperarousal, one of the signs of psychiatric distress.

27 May 2021

No-cancel culture: How telehealth is making it easier to keep that therapy session

When the covid-19 pandemic forced behavioral health providers to stop seeing patients in person and instead hold therapy sessions remotely, the switch produced an unintended, positive consequence: Fewer patients skipped appointments.

24 May 2021

$Mild depression may predict postoperative delirium in older adults undergoing hip fracture repair$

Mild depression may predict postoperative delirium in older adults undergoing hip fracture repair

Screening for even mild depressive symptoms before hip fracture repair may be helpful in predicting which patients are at higher risk of developing delirium after emergency surgery, according to results of a new study by researchers from Johns Hopkins Medicine.

4 May 2021

BrainMap analysis strongly affirms 'network degeneration hypothesis' theory

The brain possesses a complex architecture of functional networks as its information-processing machinery. Is the brain's network architecture itself a target of disease? If so, which networks are associated with which diseases? What can this tell us about the underlying causes of brain disorders?

29 Apr 2021

Antidepressant exposure in the womb may increase offspring's risk of affective disorders

Major depressive disorder is highly prevalent, with one in five people experiencing an episode at some point in their life, and is almost twice as common in women than in men.

12 Apr 2021

Accelerated cellular aging in depressed individuals associated with increased mortality risk

Cells from healthy individuals with major depressive disorder were found to have higher than expected rates of methylation at specific sites on their DNA, when compared to cells from healthy individuals without MDD, according to a study by a multidisciplinary team of Walter Reed Army Institute of Research and University of California San Francisco scientists, in collaboration with others.

8 Apr 2021

Individuals with Major Depressive Disorder have accelerated cellular aging

Cells from individuals with Major Depressive Disorder (MDD) were found to have higher than expected rates of methylation at specific sites on their DNA, when compared to cells from healthy individuals without MDD, according to a study by a multidisciplinary team of UC San Francisco scientists, in collaboration with others.

7 Apr 2021