Major Depressive Disorder News and Research

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Major Depressive Disorder (MDD) is a psychiatric condition characterized by depressed mood or anhedonia (significant loss of interest or pleasure). The condition affects more than 15.7 million adults and approximately 3 million adolescents (aged 13 to 17 years) in the USA each year.

Irregular sleep and poor REM sleep linked to higher risk of chronic diseases

Longitudinal data from wearable devices linked to health records show that irregular sleep patterns and inadequate REM sleep increase the risk of chronic diseases like hypertension and depression. This emphasizes the importance of consistent and high-quality sleep for overall health.

22 Jul 2024

Poverty and mental Illness: A causal relationship revealed

Poverty and mental illness are not only linked, but there is also a causal relationship. This is the conclusion of researchers from Amsterdam UMC, the University of Edinburgh and the University of Modena.

11 Jul 2024

Innovative aiTBS therapy shortens treatment duration for bipolar disorder

A potential new treatment for bipolar disorder (BP) that significantly shortens treatment time has emerged, following a randomized clinical trial using accelerated intermittent theta burst stimulation (aiTBS).

11 Jul 2024

Digital screening for depression: Does automated feedback help?

The efficacy of two versions of automated feedback following internet-based depression screening on the severity of depression.

3 Jul 2024

Extended-release ketamine tablets offer new hope for treatment-resistant depression

The BEDROC trial found that extended-release ketamine tablets (R-107) significantly improve depressive symptoms in treatment-resistant depression patients, with the 180 mg dose showing the most efficacy. The treatment was well-tolerated with minimal side effects.

26 Jun 2024

New ketamine slow-release tablet shows promise in treating severe depression

A new tablet form of ketamine has shown promise in treating severe depression, offering a potential alternative to existing clinic-based treatments that can be expensive and lacking in convenience for some patients.

24 Jun 2024

Personalized brain circuit scores define six depression and anxiety biotypes

Researchers used functional magnetic resonance imaging data on brain circuit function to derive interpretable, personalized brain circuit dysfunction scores for patients with anxiety and depression.

19 Jun 2024

Running therapy matches antidepressants for mental health, surpasses for physical benefits

Researchers found that while both antidepressants and group running therapy effectively improved mental health in patients with anxiety and depression, running therapy had significantly better outcomes for physical health indicators.

26 May 2024

Psilocybin use initiates hyperconnectivity in the brain linked to ego-modifying effects

A new study shows that the use of psilocybin, a compound found in the widely known "magic mushrooms," initiates a pattern of hyperconnectivity in the brain linked to the ego-modifying effects and feelings of oceanic boundlessness.

23 May 2024

Education boosts well-being, but intelligence can bring you down, study suggests

Study explores causal relationships between educational attainment, intelligence, and well-being, revealing that while education positively impacts well-being, higher intelligence may have a negative effect.

13 May 2024

Western diet linked to chronic diseases by gut microbiota disruption

The Western diet disrupts gut microbiota and gut barrier function, increasing the risk of non-communicable chronic diseases through chronic low-grade inflammation.

13 May 2024

Novel head-mounted device shows promise in alleviating depression symptoms

A head-mounted device that generates an ultra-low frequency ultralow magnetic field has been found to improve the symptoms of four male patients diagnosed with major depressive disorder.

8 May 2024

Study sheds light on the promising role of virtual reality in treating depression

A new study published in JMIR Mental Health sheds light on the promising role of virtual reality (VR) in treating major depressive disorder (MDD).

6 May 2024

Reduction of prenatal depression associated with higher full-term birth rates

The effect of lowering prenatal mother depression on gestational duration.

25 Apr 2024

The vital role of therapeutic alliances in psychedelic treatment

Drug effects have dominated the national conversation about psychedelics for medical treatment, but a new study suggests that when it comes to reducing depression with psychedelic-assisted therapy, what matters most is a strong relationship between the therapist and study participant.

23 Apr 2024

Study finds microdosing LSD leads to longer sleep: Insights from a controlled trial

A phase I trial to assess the effect of micro-dosing of lysergic acid diethylamide (LSD) on the sleep.

17 Apr 2024

Ketamine's rapid impact on depression linked to immune system pathways

Study reveals ketamine's potent anti-inflammatory effects on neurological disorders, showing promise for treating major depressive disorder through modulation of neuroimmune pathways.

15 Apr 2024

Can psychedelics improve sexual functioning and satisfaction?

The influence of psychedelics on sexual functioning.

15 Apr 2024

Is psilocybin safe for treating depression and anxiety?

A study in JAMA Network Open examined the acute adverse effects of therapeutic doses of psilocybin for treating depression and anxiety, focusing on its safety profile by assessing the occurrence of immediate side effects like headache, nausea, and elevated blood pressure among others.

12 Apr 2024

Gut-friendly psychobiotics could brighten moods and fight depression

Review uncovers that psychobiotics may offer supportive treatment for depression by restoring gut microbiome balance and positively influencing the microbiome-gut-brain axis, which is crucial for mental health and well-being.

8 Apr 2024