Mammalian Cells News and Research

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€7.6 million ERC Synergy grant to support research on molecular mechanisms of viral infection

The interdisciplinary team wants to investigate the molecular mechanisms of viral infection, which will contribute to fundamental knowledge about cellular regulation and new concepts for broad-spectrum anti-viral therapy. The funding amounts to 7.6 million euros.

11 Oct 2019

CRISPR RNA-cutting enzyme programmed to destroy viruses in human cells

Many of the world's most common or deadly human pathogens are RNA-based viruses -- Ebola, Zika and flu, for example -- and most have no FDA-approved treatments.

10 Oct 2019

New link between two important products of nitric oxide discovered

Ever since three US-based researchers working independently unveiled the role of nitric oxide in mediating blood vessel dilation, endothelial cell contraction and smooth muscle relaxation, their discoveries have served as a basis for novel treatments for high blood pressure and erectile dysfunction, among other conditions.

4 Oct 2019

Researchers discover metabolic vulnerability in cancer cells with mutated spliceosomes

A research team from the Johns Hopkins Kimmel Cancer Center reports it has discovered a metabolic vulnerability in multiple types of cancer cells that bear a common genetic mutation affecting cellular machines called spliceosomes.

From Johns Hopkins Medicine 3 Oct 2019

New mechanism that controls DNA repair identified

Deoxyribonucleic acid (DNA), is the macromolecule that holds all hereditary and genetic information. Continuously under assault, alterations and damage to DNA can lead to many different health issues, including cancer.

2 Oct 2019

New $1.5 million grant could help develop innovative methods to halt spread of cancer

One of the most devastating pieces of news a cancer patient can receive is that their cancer has spread to other parts of the body.

1 Oct 2019

Scientists use ultrasound to detect active genes in live cells

A startling new study shows that ultrasound can help scientists to understand whether specific genes are in the active or inactive state in live cells.

27 Sep 2019

Researchers use high-throughput mutagenesis approach to study ALS

Amyotrophic lateral sclerosis is a devastating and incurable nervous system disease that affects nerve cells in the brain and spinal cord, causing loss of muscle control and normally death within a few years of diagnosis.

23 Sep 2019

RNA hitches lysosome rides to make proteins far away from the nucleus

Proteins inside a cell are often made at the site where they are used, rather than being shipped long distances. This is so with nerve cells which have long cell extensions in the form of axons and dendrites, up to four feet long in some case

22 Sep 2019

Stanford-UCSF researchers report new cure for common cold in human cells and mice

Temporarily disabling a single protein inside our cells might be able to protect us from the common cold and other viral diseases, according to a study led by researchers at Stanford University and University of California-San Francisco.

16 Sep 2019

Message transfer between mammal neurons regulated by 'clamp'

A fundamental question in nerve biology brings to mind a race car at the starting line: The engine is revving, but the brake is on. The system is ready to go, but under tight control.

9 Sep 2019

Influenza A virus host range restricted by dysregulated expression of M gene segment

The host range of the influenza A virus is restricted by dysregulated expression of the M viral gene segment, according to a study published August 15 in the open-access journal PLOS Pathogens by Anice Lowen and John Steel of Emory University School of Medicine, and colleagues.

From PLOS ONE 16 Aug 2019

Researchers identify new transmembrane protein as chloride ion channel

In the human body the salt content of cells and their surrounding is regulated by sophisticated transport systems.

14 Aug 2019

New gene-editing study finds protective genes against Zika virus

Tel Aviv scientists have discovered certain genes that protect the host organism against attack by Zika virus, raising hopes of an eventual vaccine or cure for this dreaded viral disease.

28 Jul 2019

Scientists find surprising insight into Legionnaires’ disease

The incidence of Legionnaires' disease has increased in the past two decades. The natural habitat of Legionella is freshwater biotopes, where they mainly reproduce in amoebae.

24 Jul 2019

Researchers identify chemical compounds that increase stability of haploid cell

Since the emergence of molecular genetics more than fifty years ago, scientists have tried to isolate haploid mammalian cells, that is, cells with half the number of chromosomes contained in somatic cells. Haploid cells are a powerful genetic tool to analyze gene function.

17 Jul 2019

Scientists create powerful method for 'directed evolution' of molecules

UNC School of Medicine scientists created a powerful new "directed evolution" technique for the rapid development of scientific tools and new treatments for many diseases.

5 Jul 2019

Scientists discover new way to direct stem cells to heart tissue

In a world first, scientists have found a new way to direct stem cells to heart tissue. The findings, led by researchers at the University of Bristol and published in Chemical Science, could radically improve the treatment for cardiovascular disease, which causes more than a quarter of all deaths in the UK.

4 Jul 2019

'Scissors' component of CRISPR/Cas9 sometimes gets stuck

In biotech these days, CRISPR/Cas9 is a hot topic, because of its utility as a precise gene editing tool. Before humans repurposed it, CRISPR/Cas9 was a sort of internal immune system bacteria use to defend themselves against phages, or viruses that infect bacteria, by slicing up the phages' DNA.

2 Jul 2019

New technology harnesses bacterial jumping genes for precise DNA integration

A new discovery by researchers at Columbia University Vagelos College of Physicians and Surgeons could fix one of the major shortcomings of current gene-editing tools, including CRISPR, and offer a powerful new approach for genetic engineering and gene therapy.

13 Jun 2019