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New type of anti-clotting drug called Apixaban

The dean of the University of Oklahoma College of Public Health and a team of scientists worldwide have found a better way to prevent deadly blood clots after joint replacement surgery - a major problem that results in thousands of unnecessary deaths each year. The research appears this week in the New England Journal of Medicine.

11 Aug 2009

Regular use of aspirin after colorectal cancer diagnosis may reduce the risk of cancer death

In the August 12 issue of the Journal of the American Medical Association, the study's authors also find that the aspirin-associated survival advantage was seen primarily in patients with tumors expressing the COX-2 enzyme, a characteristic of two-thirds of colorectal cancers.

11 Aug 2009

$Denosumab reduces fracture risk in men receiving androgen-deprivation therapy for prostate cancer$

Denosumab reduces fracture risk in men receiving androgen-deprivation therapy for prostate cancer

Twice-yearly treatment with denosumab, a new targeted therapy to stop bone loss, increased bone density and prevented spinal fractures in men receiving androgen-deprivation therapy for prostate cancer.

11 Aug 2009

Children of deployed parents at greater risk for psychosocial problems

About one-third of children with a parent deployed in the Global War on Terror are at high risk for psychosocial problems, suggests a study in the August issue of the Journal of Developmental & Behavioral Pediatrics. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health, a leading provider of information and business intelligence for students, professionals, and institutions in medicine, nursing, allied health and pharmacy.

11 Aug 2009

AIDS Research Center earns $7.5 million grant renewal

The University of Alabama at Birmingham (UAB) Center for AIDS Research (CFAR) has won a $7.5 million grant to continue its work in the research, prevention and treatment of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS).

11 Aug 2009

Discovery of link between over-indebtedness and obesity

Scientists at the University of Mainz have discovered a close correlation between over-indebtedness and obesity. According to the report published in the journal BMC Public Health, over-indebted Germans are more likely to be overweight or obese than the population in general.

11 Aug 2009

Oxygen nanosensor could improve tumor imaging

A new material developed at the University of Virginia - an oxygen nanosensor that couples a light-emitting dye with a biopolymer - simplifies the imaging of oxygen-deficient regions of tumors. Such tumors are associated with increased cancer aggressiveness and are particularly difficult to treat.

11 Aug 2009

Holography helps tackle ovarian cancer

Two University of Arizona researchers have formed a research team to design, build and evaluate two versions of an ovarian cancer medical imaging and screening instrument that will use holographic components in a new type of optical microscope.

11 Aug 2009

Easy-to-swallow drug restores autoimmune function in diabetics

Found in 30% of all human cancer tumors, the Ras protein literally "drives cells crazy," says Prof. Yoel Kloog, the dean of the Faculty of Life Sciences at Tel Aviv University. Prof. Kloog was the first in the world to develop an effective anti-Ras drug against pancreatic cancer, currently in clinical trials. Now, new research published in the June issue of the European Journal of Pharmacology shows that the drug might be able to slow the progression of diabetes as well.

11 Aug 2009

Unigene Labs reports financial results for three months ended June 30, 2009

Revenue for the three months ended June 30, 2009 was $4,297,000, compared to $4,978,000 for the three months ended June 30, 2008. Revenue for both periods primarily consisted of Fortical sales and royalties, which were $3,807,000 for the three months ended June 30, 2009, and $4,110,000 for the three months ended June 30, 2008.

11 Aug 2009

Characteristic pathological findings and effects of ecabet sodium in rat reflux esophagitis

Recently, the number of patients with GERD has increased in Japan. However, there have been few reports about the pathological findings in the esophageal squamous epithelium, and there are differing opinions among pathologists about the findings considered characteristic of chronic reflux esophagitis.

11 Aug 2009

STAT3 is required for proliferation and maintenance of multipotency in glioblastoma stem cells

In a study published online in advance of print in Stem Cells, Tufts researchers report that the STAT3 gene regulates cancer stem cells in brain cancer. Cancer stem cells have many characteristics of stem cells and are thought to be the cells that drive tumor formation. The researchers report that STAT3 could become a target for cancer therapy, specifically in Glioblastoma multiforme (GBM), a type of malignant and aggressive brain tumor.

11 Aug 2009

Don't smoke, exercise and eat sensibly to reduce risk of chronic disease

Four healthy lifestyle factors - never smoking, maintaining a healthy weight, exercising regularly and following a healthy diet - together appear to be associated with as much as an 80 percent reduction in the risk of developing the most common and deadly chronic diseases, according to a report in the August 10/24 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

11 Aug 2009

New class of molecules capable of blocking formation of tau protein fibrils

A new class of molecules capable of blocking the formation of specific protein clumps that are believed to contribute to Alzheimer’s disease pathology has been discovered by researchers at the University of Pennsylvania School of Medicine. By assaying close to 300,000 compounds, they have identified drug-like inhibitors of AD tau protein clumping, as reported in the journal Biochemistry.

11 Aug 2009

'Nanobee' drug delivery to tumors

When bees sting, they pump poison into their victims. Now the toxin in bee venom has been harnessed to kill tumor cells by researchers at Washington University School of Medicine in St. Louis. The researchers attached the major component of bee venom to nano-sized spheres that they call nanobees.

11 Aug 2009

Research shows how schizophrenia works in the brain

Schizophrenia waits silently until a seemingly normal child becomes a teenager or young adult. Then it swoops down and derails a young life.

11 Aug 2009

Sorting out the truth in the health care debate

The New York Times reports in a "primer on the details of health reform" that Republican criticism of a government-run insurance plan to compete with private health insurance as "socialized medicine" "seems overblown," it reports. "The Congressional Budget Office has estimated that, under the House bill, the number of people with employer-sponsored insurance would climb to 162 million in 2016, which is 3 million more than expected under current law. Further, it said, enrollment in the proposed public plan might total 11 million, far lower than estimates cited by Republicans."

11 Aug 2009

Discovery of a potential target for metastatic cancer

The deadliest part of the cancer process, metastasis, appears to rely on help from macrophages, potent immune system cells that usually defend vigorously against disease, researchers at Albert Einstein College of Medicine of Yeshiva University report.

11 Aug 2009

Childhood cancer survivors treated with radiation may have an increased risk of diabetes

Childhood cancer survivors treated with total body or abdominal radiation may have an increased risk of diabetes, according to a report in the August 10/24 issue of Archives of Internal Medicine, one of the JAMA/Archives journals. This correlation does not appear to be related to patients’ body mass index or physical inactivity.

11 Aug 2009

New molecule blocks lymphangiogenesis

Researchers in the laboratory of Dr. Jayakrishna Ambati at the University of Kentucky have discovered the first naturally occurring molecule that selectively blocks lymphatic vessel growth. In an article in the Aug. 9, 2009 online edition of Nature Medicine, they report the identification of a new molecule known as soluble VEGFR-2 that blocks lymphangiogenesis - the growth of lymphatics - but not blood vessel growth.

11 Aug 2009