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New kidney chip offers breakthrough for drug development and personalized medicine

Developing advanced drug screening tools is crucial for the advancement of personalized medicine and the creation of more effective treatments. One organ receiving particular attention in this area is the kidney.

19 Sep 2024

Study paves way for revolutionizing the management of muscle disorders

The type 1 ryanodine receptor (RyR1) is an important calcium release channel in skeletal muscles essential for muscle contraction.

18 Sep 2024

Early specificity testing crucial for antibody drug safety

Integral Molecular, a leader in antibody discovery and characterization, has published new research in the journal mAbs, revealing that as many as one-third of antibody-based drugs exhibit nonspecific binding to unintended targets.

18 Sep 2024

Lipid molecule fuels cancer growth

Cancer cells seldom start off stealthy. Quite to the contrary, they announce their presence to the immune system by planting chemical red flags right on their membranes. Once alerted, the body's defenses can swoop in, destroying rogue cells before they can do much damage. Lying at the heart of this early warning system are lipids, fatty compounds previously seen by cancer biologists primarily as a fuel source for burgeoning tumors.

18 Sep 2024

LJI breakthrough offers hope for universal antiviral against filoviruses

At this moment, the world has few tools to combat deadly filoviruses, such as Ebola and Marburg viruses. The only approved vaccine and antibody treatments protect against just one filovirus species.

17 Sep 2024

Monoclonal antibodies could help provide an answer to antimicrobial resistance

Monoclonal antibodies – treatments developed by cloning a cell that makes an antibody – could help provide an answer to the growing problem of antimicrobial resistance, say scientists.

16 Sep 2024

Review highlights mitochondrial dysfunction in cholestatic liver injury

Bile acids are essential signaling molecules derived from cholesterol metabolism in the liver and are crucial for the digestion and absorption of fats.

16 Sep 2024

Cardiovascular risks of COVID-19 antivirals

Study reviews cardiovascular side effects linked to antiviral therapies for COVID-19, highlighting the need for careful consideration when prescribing these drugs to high-risk patients.

16 Sep 2024

Biological condensates affect cellular behavior on a global scale

Most biological chemistry research has historically focused on the obvious cogs of machinery that keep life moving. Folding proteins, genetic activity and electrical signaling pathways are the easiest targets for finding irregularities that lead to disease.

13 Sep 2024

Salt can boost antitumor responses of T cells

Elevated sodium levels in tumors boost T-cell metabolic fitness and cytotoxicity, revealing potential avenues for improving cancer therapies.

13 Sep 2024

Novel drug delivery system aims to prevent hearing loss from cisplatin chemotherapy

The chemotherapy drug cisplatin is a lifesaver for many adults and children diagnosed with cancer, but it often causes hearing loss, a side effect that can diminish quality of life following treatment.

13 Sep 2024

New research aims to target IL-6 for treating diabetic retinopathy

Scientists at the Medical College of Georgia at Augusta University are searching for a new treatment target for a common complication of diabetes that can cause retinal blood vessels to break down, leak, or become blocked.

12 Sep 2024

AI tool enhances cancer diagnosis by transforming standard tissue images

VirtualMultiplexer transforms histology images into detailed cancer markers, streamlining diagnostics and enhancing patient outcomes through AI innovation.

12 Sep 2024

Researchers uncover clues to the mechanism behind vitiligo

Skin pigmentation disorders affect people across the world. One of them, vitiligo, is said to have a worldwide incidence of 1-2%.

10 Sep 2024

High linoleic acid intake during pregnancy may harm fetal growth and raise obesity risk

High maternal linoleic acid intake during pregnancy may impact fetal development and increase the risk of obesity and inflammation in offspring. However, more research is needed to fully understand these effects in humans.

10 Sep 2024

Lipidomics and metabolomics as potential biomarkers for breast cancer progression

This review highlights the potential of lipidomic and metabolomic biomarkers in predicting breast cancer prognosis and therapy response, enhancing patient care.

5 Sep 2024

A new genetic perspective on monilethrix

From infancy and usually for life, some families suffer from broken hair due to a congenital form of hair loss called monilethrix. Researchers at the University Hospital Bonn and the University of Bonn have now identified causative mutations in another keratin gene, KRT31. They hope that this will improve the diagnosis of this rare disease. Their results have now been published in the renowned "British Journal of Dermatology".

5 Sep 2024