Metabolic Disease News and Research

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LogicBio team to present data on preclinical effectiveness of GeneRide platform

LogicBio Therapeutics, Inc., a genetic medicine company founded to develop safe medicines with lasting therapeutic benefit for children with life-threatening diseases, today announced it will be presenting data on the company's technology and robust preclinical pipeline at the annual meeting of the American Society of Gene & Cell Therapy at the Hilton Chicago, from May 16-19, 2018.

14 May 2018

UTSW study provides insight into potential new therapeutic approaches for skin diseases

Research at UT Southwestern has shown that targeting metabolism in growing cells holds promise for the treatment of skin diseases like psoriasis that are characterized by skin overgrowth resulting from excess cell division, known as hyperproliferation.

4 May 2018

Fat-controlling hormones increase metabolism in both exercise and cold

Sad but true, we don't all respond equally to exercise. Researchers at Joslin Diabetes Center have uncovered a new kind of clue to this variable response--a hormone whose levels in the bloodstream rise sharply in exercise as well as in cold.

2 May 2018

Hypercaloric food intake promotes major behavioral and cognitive changes

Mice fed on a high fat or chocolate-based diet show abnormal feeding behaviors such as snacking, bingeing and disrupted eating patterns, according to new research from scientists at the Centre for Genomic Regulation and the Pompeu Fabra University in Barcelona, Spain.

9 Apr 2018

Researchers develop improved method for calculating type 1 diabetes risk

An international research group headed by scientists from Helmholtz Zentrum München has developed a method for calculating the risk for developing type 1 diabetes that is significantly superior to earlier methods.

4 Apr 2018

UIC researchers examine how arsenic affects development of diabetes

A five-year, $2.7 million grant from the National Institute of Environmental Health Sciences will help researchers at the University of Illinois at Chicago answer basic questions about the role of arsenic in the development of diabetes and examine the mechanisms by which selenoproteins - found in the human body in 25 different forms - counter the effects of arsenic.

9 Mar 2018

Chemist finds how to control blood sugar without usual side effects

Chemist Robert Doyle in the College of Arts and Sciences at Syracuse University has figured out how to control glucose levels in the bloodstream without the usual side effects of nausea, vomiting or malaise.

11 Feb 2018

Endogenous peptide improves glucose and insulin tolerance and reduces body weight in mice

Treating obese mice with catestatin, a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report University of California San Diego School of Medicine researchers.

7 Feb 2018

Altered immune cell clocks may contribute to metabolic diseases in shift workers

About 15 million Americans don't have a typical nine-to-five workday, and many of these--nurses, firefighters and flight attendants, among many other professions--may see their schedule change drastically one week to the next.

7 Feb 2018

Research reveals why patients with diabetes have poorer prognosis for prostate cancer

Men with type 2 diabetes are less likely to develop prostate cancer than patients without diabetes. However, the mortality rate is higher.

31 Jan 2018

Researchers pinpoint mechanism for conversion of white fat into brown fat

An international team of researchers led from Karolinska Institutet have, in experiments on mice, pinpointed a mechanism for the conversion of energy-storing white fat into energy-expending brown fat.

5 Jan 2018

Scientists discover mechanism that amplifies autoimmune reaction in early stage islet autoimmunity

Scientists at Helmholtz Zentrum München have discovered a mechanism that amplifies the autoimmune reaction in an early stage of pancreatic islet autoimmunity prior to the progression to clinical type 1 diabetes.

4 Jan 2018

Researchers identify mechanism that regulates signaling events leading to cancer metastasis

Understanding how cancer cells are able to metastasize -- migrate from the primary tumor to distant sites in the body -- and developing therapies to inhibit this process are the focus of many laboratories around the country.

18 Dec 2017

Studies identify key characteristics that may allow some obese people to have 'healthier' fat tissue

One little understood paradox in the study of obesity is that overweight people who break down fat at a high rate are less healthy than peers who store their fat more effectively.

1 Nov 2017

Adopting healthy diet can help reverse risk of high triglycerides, despite genetic predisposition

Triglycerides, a type of fat in the blood, are important for good health. But having high triglycerides might increase a person's risk of heart disease, and may be a sign of metabolic syndrome--a combination of high blood pressure, high blood sugar, and too much fat accumulation at the waist.

25 Oct 2017

Crown Bioscience announces availability of new translational models for obesity and diabetes in Europe

Crown Bioscience, a wholly-owned subsidiary of Crown Bioscience International and a global drug discovery and development services company providing translational platforms to advance oncology, inflammation, cardiovascular and metabolic disease research, announces the availability of their proprietary FATZO model in a European based laboratory.

12 Oct 2017

CRI scientists challenge oldest concept in tumor metabolism

Scientists at the Children's Medical Center Research Institute at UT Southwestern (CRI) have discovered that lactate provides a fuel for growing tumors, challenging a nearly century-old observation known as the Warburg effect.

6 Oct 2017

Fructose plays more damaging role than glucose in fatty liver disease, mice study shows

If you're one of the two billion people in the world who are over-weight or obese, or the one billion people with fatty liver disease, your doctor's first advice is to cut calories-;and especially to cut down on concentrated sugars such as high-fructose corn syrup, a sugar found in sweetened beverages and many other processed foods.

4 Oct 2017

Enhanced levels of NPs in adipose tissue protect against obesity and insulin resistance

Researchers at Sanford Burnham Prebys Medical Discovery Institute in Lake Nona, Florida have shown that enhanced natriuretic peptide (NP) signaling in adipose tissue protects against obesity and insulin resistance.

26 Aug 2017

Almost every fourth hospital patient suffers from diabetes, study finds

One in four patients in a university hospital suffers from diabetes (22 percent), and again as many suffer from prediabetes (24 percent).

24 Aug 2017