Metabolic Disorders News and Research

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Virtual human metabolic network for medical science

Bioengineering researchers at UC San Diego have painstakingly assembled a virtual human metabolic network that will give researchers a new way to hunt for better treatments for hundreds of human metabolic disorders, from diabetes to high levels of cholesterol in the blood.

30 Jan 2007

SH2B1 protein plays a key role in controlling body weight, response to insulin and leptin

A single protein in brain cells may act as a linchpin in the body's weight-regulating system, playing a key role in the flurry of signals that govern fat storage, sugar use, energy balance and weight, University of Michigan Medical School researchers report.

29 Jan 2007

Allergic reactions to insulin have declined and Continuous Subcutaneous Insulin Infusion could reduce them further

A review of published research from the University of Liege, Belgium, reveals a decline in the number of people experiencing allergic reactions to insulin. This is largely due to better purification of animal insulin and the introduction of human recombinant insulin.

8 Jan 2007

Bulimia may result from hormonal imbalance

Bulimia is normally regarded as a mental illness that should be treated with cognitive behavioural therapy (CBT).

3 Jan 2007

Heel prick test can cause unnecessary parental stress

Virtually all babies in the U.S. have their heels pricked soon after birth to get a blood sample for genetic testing.

5 Jun 2006

Canadian researchers close in on new treatments for type 2 diabetes

Researchers funded by the Canadian Institutes of Health Research (CIHR) and the Canadian Diabetes Association (CDA) have identified an unsuspected role of a protein named SHP-1 that could constitute a new therapeutic path against Type 2 Diabetes.

29 May 2006

Healthy habits and appropriate treatments help prevent stroke

Stroke is the third leading cause of death and a major source of disability in the United States. Every year about 700,000 people in the United States suffer a stroke, resulting in nearly 158,000 deaths.

10 May 2006

Protein mutated in cancer found to be linked to diabetes

A study published by Nature has defined the function of p110 alpha, the flag-ship molecule of the eight member PI3K family, which is one of the most frequently activated pathways in cancer. The function of p110 alpha in the body has eluded researchers for over a decade but a new approach to generating mouse models, has allowed investigators to solve the mystery and yield important information for planned clinical trials with PI3K inhibitors.

25 Apr 2006

Novel compound may help fight obesity

A new study reveals an attractive new target for therapies aimed at the treatment of obesity and related metabolic disorders, researchers report in the March Cell Metabolism.

9 Mar 2006

8 million children born every year with serious birth defects

According to a new report, every year an estimated 8 million children are born with a serious birth defect of genetic or partially genetic origin.

31 Jan 2006

Chemical warfare agent detection technology used to treat lung disease

A new technique based on the same technology used to detect chemical warfare agents and explosives is being employed by scientists at The University of Manchester to treat hospital patients with lung disease.

From The University of Manchester 23 Jan 2006

Sugary drinks push Latino kids toward type 2 diabetes

Overweight Latino children who consume lots of sugar-especially in sugary drinks-show signs of beta cell decline, a precursor of type 2 diabetes, according to researchers at the Keck School of Medicine of the University of Southern California.

26 Nov 2005

Increlex - first major innovation in 20 years for the treatment of growth failure

Rush University Medical Center is participating in a clinical trial to evaluate the potential benefit of the first major innovation in 20 years for the treatment of growth failure.

26 Sep 2005

Study reveals critical molecular events in the origin of fat cells

A new study reveals critical molecular events in the origin of fat cells. The findings are central to understanding chronic diseases, such as obesity and diabetes, as fat cells produce hormones critical for metabolic control, the researchers said.

21 Sep 2005

Human fat cells produce a protein that is linked to both inflammation and an increased risk of heart disease and stroke

Researchers at The University of Texas M. D. Anderson Cancer Center and The University of Texas Health Science Center at Houston have found that human fat cells produce a protein that is linked to both inflammation and an increased risk of heart disease and stroke.

19 Sep 2005

Obese men may not process carbohydrates as efficiently as obese women

Obese men may not process carbohydrates as efficiently as obese women, a condition that can, ultimately, lead to a decrease in fitness level and the development of metabolic disorders.

12 Jul 2005

Obese men may not process carbohydrates as efficiently as obese women

A new study published in the July issue of CHEST, the peer-reviewed journal of the American College of Chest Physicians (ACCP), showed that severely obese men were more carbohydrate intolerant and had less physical endurance than severely obese women, leading researchers to believe that gender plays a strong role in physical fitness and a person's ability to metabolize carbohydrates.

11 Jul 2005

Pregnancy and birth factors may determine likelihood of polycystic ovarian syndrome

New research suggests that the way baby girls develop in the womb may affect whether or not they develop polycystic ovarian syndrome (PCOS) as adults and the severity of the symptoms if they do.

27 Jun 2005

Rimonabant study shows significant improvements in HbA1c and cardiometabolic risk factors in people with type 2 diabetes

The reported results of a one-year phase III study in 1045 people with type 2 diabetes treated with rimonabant, the first in a new class of therapeutic agents called selective CB1 Blockers, were that rimonabant 20 mg significantly improved HbA1c (a measure of blood sugar control), dyslipidemia (abnormal levels of fat in the blood), and systolic blood pressure with a concomitant substantial reduction in abdominal obesity in people with type 2 diabetes treated with oral anti-diabetic medications and requiring further control.

12 Jun 2005

Link between insomnia and obesity

A possible link between lack of sleep (insomnia) and obesity has been traced to hypocretin/orexin cells in the hypothalamus region of the brain that are easily excited and sensitive to stress, Yale School of Medicine researchers report in the April issue of Cell Metabolism.

13 Apr 2005

Metabolic Disorders News and Research

Virtual human metabolic network for medical science

SH2B1 protein plays a key role in controlling body weight, response to insulin and leptin

Allergic reactions to insulin have declined and Continuous Subcutaneous Insulin Infusion could reduce them further

Bulimia may result from hormonal imbalance

Heel prick test can cause unnecessary parental stress

Canadian researchers close in on new treatments for type 2 diabetes

Healthy habits and appropriate treatments help prevent stroke

Protein mutated in cancer found to be linked to diabetes

Novel compound may help fight obesity

8 million children born every year with serious birth defects

Chemical warfare agent detection technology used to treat lung disease

Sugary drinks push Latino kids toward type 2 diabetes

Increlex - first major innovation in 20 years for the treatment of growth failure

Study reveals critical molecular events in the origin of fat cells

Human fat cells produce a protein that is linked to both inflammation and an increased risk of heart disease and stroke

Obese men may not process carbohydrates as efficiently as obese women

Obese men may not process carbohydrates as efficiently as obese women

Pregnancy and birth factors may determine likelihood of polycystic ovarian syndrome

Rimonabant study shows significant improvements in HbA1c and cardiometabolic risk factors in people with type 2 diabetes

Link between insomnia and obesity

Arrayed CRISPR Screening for Revolutionizing Target Discovery

Innovations in baculovirus–insect cell expression systems

Compound Management and its Crucial Role in Early Pharmaceutical Research

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