Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Daily walnut consumption positively impacts blood cholesterol levels in older adults

Initial findings from the Walnuts and Healthy Aging study presented at Experimental Biology 2016 (EB) indicate that daily walnut consumption positively impacts blood cholesterol levels without adverse effects on body weight among older adults.

4 Apr 2016

Altered metabolism of two essential amino acids helps drive development of glioblastoma

The altered metabolism of two essential amino acids helps drive the development of the most common and lethal form of brain cancer, according to a new study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute.

2 Apr 2016

YAP protein plays vital role in development of human neural crest

The Hippo/YAP signalling pathway plays a crucial role when the cells of the neural crest - a structure that generates cell types such as bones and nerve tissue - specialise for a certain function in the human embryo and migrate to their target region within the body.

22 Mar 2016

Metabolite in gut microbiome could improve outcomes after bone marrow transplant

Could playing better defense make bone marrow transplants more successful? With this question in mind, researchers began looking at whether the trillions of little bugs and bacteria living in our gastrointestinal tract could be the key to playing defense.

22 Mar 2016

WSU researcher explores new drugs to treat neurological disorders linked to autophagic dysfunction

Repairing the brain's "house-cleaning function," which could help people with Alzheimer's, Parkinson's, amyotrophic lateral sclerosis (ALS) and 100 other diseases, is the focus of recently funded research at Washington State University.

17 Mar 2016

Acute heart failure patients often have high levels of red meat metabolite

Patients with acute heart failure often have high levels of the metabolite trimethylamine N-oxide (TMAO) - of which red meat is a major dietary source - according to researchers from the University of Leicester.

19 Feb 2016

Chronic low-dose exposure to organochlorine pesticides linked to future cognitive impairment

Individuals subjected to chronic low-dose exposure to organochlorine pesticides show and increased risk to obtain a future diagnosis of cognitive impairment. This is shown in a study now published in Environmental International.

18 Feb 2016

Research findings identify potential genetics-guided precision medicine for leukemia patients

An international research team has determined how inherited gene variations lead to severe drug toxicity that may threaten chances for a cure in children with leukemia. St. Jude Children's Research Hospital scientists led the study, results of which set the stage to expand the use of a patient's genetic make-up to tailor chemotherapy.

16 Feb 2016

Missouri S&T researcher comes up with patented breast cancer screening device

Cancer screening could soon be as simple as giving a urine sample using a patented device developed by a Missouri University of Science and Technology researcher. This week, Wyoming-based Cancer.im Inc., a Viratech Corp. company and social network for cancer patients, survivors and caretakers, announced an agreement with Missouri S&T to commercialize the device.

4 Feb 2016

Scientists explore how antidepressants affect fetuses during pregnancy

Depression is a serious issue for expecting mothers. Left untreated, depression could have implications for a fetus's health. But treating the disease during pregnancy may carry health risks for the developing fetus, which makes an expecting mother's decision whether to take medication a very difficult one.

4 Feb 2016

Second-hand smoke exposure linked to larger waist, poorer cognition in children

Exposure to second-hand smoke is associated with a larger waist and poorer cognition in children, researchers say.

29 Jan 2016

Study findings may help explain why risk of stroke changes after menopause

Risk of stroke in women may come down to a compound the body produces from estrogen known as 2-methoxyestradiol (2-ME). Furthermore, the compound's therapeutic potential may extend beyond treating stroke in women to healing brain injuries in men, a new study in American Journal of Physiology—Endocrinology and Metabolism reports.

20 Jan 2016

Researchers reveal totally new biological mechanism that underlies cancer

In a landmark study, researchers from the Broad Institute and Massachusetts General Hospital reveal a completely new biological mechanism that underlies cancer. By studying brain tumors that carry mutations in the isocitrate dehydrogenase (IDH) genes, the team uncovered some unusual changes in the instructions for how the genome folds up on itself.

13 Jan 2016

ORNL's cell-free protein synthesis system can help save lives of soldiers injured in remote locations

Lives of soldiers and others injured in remote locations could be saved with a cell-free protein synthesis system developed at the Department of Energy's Oak Ridge National Laboratory.

30 Dec 2015

Experimental drugs that modify cell metabolism also halt tumor growth

Experimental drugs that alter cell metabolism also halted tumor growth and extended survival in mice with cancers linked to changes in the same gene, according to a new study led by researchers at NYU Langone Medical Center, its Laura and Isaac Perlmutter Cancer Center and Massachusetts General Hospital.

15 Dec 2015

ESSA reports net loss of $11.5 million for year ended September 30, 2015

ESSA Pharma Inc. today reported financial results for the year ended September 30, 2015. Amounts, unless specified otherwise, are expressed in Canadian dollars and in accordance with International Financial Reporting Standards ("IFRS").

15 Dec 2015

Lexicon announces top-line results from TELECAST Phase 3 study of telotristat etiprate

Lexicon Pharmaceuticals, Inc. announced today that top-line data from its TELECAST Phase 3 study showed results of telotristat etiprate in treating carcinoid syndrome in cancer patients with metastatic neuroendocrine tumors consistent with the clinical benefit observed in its pivotal TELESTAR study.

1 Dec 2015

New test can detect drug abuse faster

A new test for club drugs like ketamine can detect low levels of drugs in urine and plasma, making it faster, easier and cheaper to identify them. The authors of the study, published in Journal of Chromatography B, say it could give authorities the boost they need to keep up with trends drug (ab)use.

26 Nov 2015

Drinking moderate amounts of caffeine during pregnancy does not harm baby's intelligence

Women drinking and eating moderate amounts of caffeine during pregnancy should be reassured that they are not harming their child's intelligence, according to a study from The Research Institute at Nationwide Children's Hospital that was published in the American Journal of Epidemiology.

20 Nov 2015

Identifying new mechanism for aspirin in cancer prevention

Aspirin has been shown to decrease the risk of colorectal cancer and possibly other cancers. However, the risk of side effects, including in some cases severe gastrointestinal bleeding, makes it necessary to better understand the mechanisms by which aspirin acts at low doses before recommending it more generally as a preventative, says Cornelia Ulrich, PhD, Senior Director of Population Sciences at Huntsman Cancer Institute in Salt Lake City.

19 Nov 2015