Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Researchers find tamoxifen's power comes from endoxifen

Mayo Clinic researchers have discovered that a chemical known as endoxifen appears to be the primary metabolite responsible for the effectiveness of tamoxifen in treating breast cancer, and that it works against cancer in an entirely unexpected way.

12 Dec 2008

New class of anti-inflammatory drugs

In the treatment of pain, inflammation and fever, non-steroid anti-rheumatic drugs (NSAR) such as acetylsalicylic acid - more commonly known as Aspirin - or Ibuprofen have always been popular choices.

10 Dec 2008

Environmental tobacco smoke linked to behavioral problems in boys with asthma

Boys with asthma who are exposed to environmental tobacco smoke have higher degrees of hyperactivity, aggression, depression and other behavioral problems, according to researchers at Cincinnati Children's Hospital Medical Center.

5 Dec 2008

More evidence on why the Mediterranean diet is good for heart

Researchers have discovered one potential mechanism by which briefly cutting off, then restoring, blood flow to arteries prior to a heart attack lessens the damage caused, according to a study published today in the journal Cardiovascular Research.

2 Dec 2008

Babies exposed to tobacco in utero more irritable, difficult to soothe

Previous studies have shown that babies exposed to tobacco in utero are more likely to have a low birth weight and are at increased risk for sudden infant death syndrome.

1 Dec 2008

Genetic variation in metabolism identified

Metabolic diseases - in particular the increasingly prevalent type 2 diabetes - are caused by a complex interaction between genetic disposition and unfavorable lifestyle, above all unbalanced diet and too little physical exercise.

30 Nov 2008

Study identifies genetic variants giving rise to differences in metabolism

Common genetic polymorphisms induce major differentiations in the metabolic make-up of the human population, according to a paper published November 28 in the open-access journal PLoS Genetics.

28 Nov 2008

Researchers discover that a lipid produced in the gut rises after eating fatty foods

As you gorge on food this holiday season, you might not want to think about the fat content of all the goodies you've indulged in.

26 Nov 2008

Novel device enhances efficacy of standard chemotherapy

NovoCure Ltd. presented results yesterday evaluating the Novo-TTF device in vitro and in a pilot clinical trial that showed the device enhanced the efficacy of standard chemotherapy (temozolomide) treatment in newly-diagnosed glioblastoma multiforme (GBM) patients.

24 Nov 2008

Smoking when pregnant doubles risk of cleft palate or lip in babies

Babies whose mothers smoked during pregnancy were more than twice as likely to have a cleft palate or lip as those whose mothers didn't, according to research results released today.

6 Nov 2008

Wide variability in rheumatoid arthritis drug Methotrexate suggests alternative dosing should be considered

Methotrexate (MTX) is commonly used to treat rheumatoid arthritis (RA) and is suggested as the "anchor" drug in treating the disease.

5 Nov 2008

Birth defects more common if pregnant mothers smoke

New research has revealed that women who smoke during pregnancy are more likely to have a baby with a birth defect - smoking during pregnancy apparently doubles the risk of the baby having a cleft lip or palate.

5 Nov 2008

New evidence strengthens link between cigarette smoke exposure and poor infant health

The damaging effects of smoking and smoke exposure can be seen at any age. Pediatricians have even noted these negative effects in various stages of infant development. The consequences of maternal smoke exposure during pregnancy can range from higher rates of prematurity to increased risk of sudden infant death syndrome.

5 Nov 2008

Fatty acids may be the culprit in Alzheimer's

According to new research from the U.S. controlling the level of a fatty acid in the brain could help treat Alzheimer's disease (AD).

21 Oct 2008

Birth control has long term effect on hormone exposure

Researchers at Wake Forest University School of Medicine may be one step closer to understanding why past oral contraceptive use dramatically lowers the risk of ovarian and uterine cancers later in life.

20 Oct 2008

New technique in blood analysis may speed diagnosis of heart attacks

Someday doctors may be able to use a blood test to confirm within minutes, instead of hours, if a patient is having a heart attack, allowing more rapid treatment that could limit damage to heart muscle.

9 Sep 2008

A fitness test for DNA

Unusually high levels of physical exertion do cause oxidative stress, but this does not result in any long-term damage to DNA. This is just one of the many outcomes revealed by an extraordinary research project funded by the Austrian Science Fund FWF that are now published. As part of this project, 42 male athletes took part both in a triathlon and an extensive biomedical study, which examined numerous physiological values parameters during the period from two days before to 19 days after the triathlon.

21 Aug 2008

Researchers uncover attack mechanism of illness-inducing bacterium found in shellfish

An infectious ocean-dwelling bacterium found in oysters and other shellfish kills its host's cells by causing them to burst, providing the invader with a nutrient-rich meal, researchers at UT Southwestern Medical Center have found.

18 Aug 2008

Human brains pay a price for being big

Metabolic changes responsible for the evolution of our unique cognitive abilities indicate that the brain may have been pushed to the limit of its capabilities. Research published today in BioMed Central's open access journal Genome Biology adds weight to the theory that schizophrenia is a costly by-product of human brain evolution.

4 Aug 2008

Experimental drug turns lab mice into long-distance runners

Trying to reap the health benefits of exercise? Forget treadmills and spin classes, researchers at the Salk Institute for Biological Studies may have found a way around the sweat and pain. They identified two signaling pathways that are activated in response to exercise and converge to dramatically increase endurance.

31 Jul 2008