Metabolites News and Research

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Systematic review: Exposure to endocrine-disruptors could elevate breast cancer risk

Exposure to certain endocrine-disrupting chemicals could elevate the risk of breast cancer, according to a new comprehensive systematic review of epidemiological research.

20 Apr 2021

New mathematical model could help design new probiotics and tailored diets to prevent diseases

A new mathematical model for the interaction of bacteria in the gut could help design new probiotics and specially tailored diets to prevent diseases. The research, from Chalmers University of Technology in Sweden, was recently published in the journal PNAS.

20 Apr 2021

Plant-derived compound isorhamnetin may have antiviral potential against SARS-CoV-2

The lack of new or repurposed drugs to treat patients with severe or critical COVID-19 has been one of the biggest hurdles to reducing mortality rates in the ongoing pandemic caused by SARS-CoV-2. A new study describes the potential for the use of the plant molecule isorhamnetin in the management of this virus.

19 Apr 2021

S-2-hydroxyglutarate keeps endothelial cells in a dormant state, reveals study

The inner surface of blood vessels is lined by a wafer-thin layer of cells known as the endothelium, which forms a crucial barrier between blood and the surrounding tissue.

16 Apr 2021

Greater intake of red and processed meat associated with worse heart function, finds study

An observational study in nearly 20,000 individuals has found that greater intake of red and processed meat is associated with worse heart function.

15 Apr 2021

Small molecule inhibitors of SARS-CoV-2 identified by screening

A new study describes the identification of small molecule inhibitors that block the catalytic activity of the crucial viral non-structural protein 5 (nsp5), using a large-scale screening method.

12 Apr 2021

Research offers an efficient approach to mine the chemical diversity of endophytic fungi

Endophytic fungi are promising producers of bioactive small molecules. Bioinformatic analysis of the genome of an endophytic fungus Penicillium dangeardii revealed 43 biosynthetic gene clusters, exhibited its strong ability to produce numbers of secondary metabolites.

8 Apr 2021

Gut microbiome communicates with horse’s cells to enhance their athletic performance

A horse’s gut microbiome communicates with its host by sending chemical signals to its cells, which has the effect of helping the horse to extend its energy output, finds a new study published in Frontiers in Molecular Biosciences.

7 Apr 2021

Prenatal exposure to phthalates is linked to altered cognitive outcomes in infants

Exposure to phthalates, a class of chemicals widely used in packaging and consumer products, is known to interfere with normal hormone function and development in human and animal studies.

7 Apr 2021

New biomarker of glucocorticoid action could help clinicians to tailor treatments

Researchers have uncovered pathways involved in the body's response to glucocorticoid treatments and identified a novel biomarker that could be used to monitor how these drugs work in patients, according to a clinical study published today in eLife.

6 Apr 2021

Researchers offer large-scale screening of potential broad-spectrum SARS-CoV-2 antivirals

A new study describes the identification of new compounds from a library, with inhibitory activity against several coronaviruses. This study shows the utility of this method, besides identifying compounds that not only inhibit viral shedding in SARS-CoV-2 cultures, but have an immunomodulatory effect that may be useful in mitigating the damaging cytokine storm typical of severe or critical COVID-19.

2 Apr 2021

Metabolic dysfunction found in mouse models of neurodevelopmental disorders

Mouse models of neurodevelopmental disorders possess unique, sex-specific metabolic dysfunctions, according to a new study in eNeuro.

1 Apr 2021

Gestational exposure to environmental toxicants linked to autistic-like behaviors in children

A new study by Simon Fraser University's Faculty of Health Sciences researchers - published today in the American Journal of Epidemiology - found correlations between increased expressions of autistic-like behaviors in pre-school aged children to gestational exposure to select environmental toxicants, including metals, pesticides, polychlorinated biphenyls (PCBs), phthalates, and bisphenol-A (BPA).

30 Mar 2021

Scientists describe the mechanisms that regulate embryonic stem cells

Scientists at the Proteomics Core Unit of the Spanish National Cancer Research Centre (CNIO), headed by Javier Muñoz, have described the mechanisms, unknown to date, involved in maintaining embryonic stem cells in the best possible state for their use in regenerative medicine.

26 Mar 2021

New technology to obtain 'protein fingerprints' in just a few minutes

Researchers from Charité - Universitätsmedizin Berlin and the Francis Crick Institute have developed a mass spectrometry-based technique capable of measuring samples containing thousands of proteins within just a few minutes.

25 Mar 2021

Study uncovers new biomarkers in patients with malignant melanoma

A team of researchers has studied the molecular profile of small “messenger” vesicles called exosomes, produced by cancer stem cells (CSCs), which play a key role in the process of carcinogenesis and metastasis in the blood of patients with malignant melanoma.

25 Mar 2021

COVID vaccines have only 17% detectable antibodies against SARS-CoV-2 virus

When clinical trials were conducted to determine the immunogenicity -- the ability to elicit an immune response -- for the first two vaccines marshaled against SARS-CoV-2the virus that causes COVID-19, one group was not among those included: people who have received solid organ transplants and others (such as those with autoimmune disorders) who are immunocompromised.

25 Mar 2021

Study identifies metabolic processes associated with multiple, unrelated diseases

Many older, but also increasingly younger, people suffer from several diseases at the same time. Scientists at the Berlin Institute of Health at Charité – Universitätsmedizin Berlin, together with colleagues from Munich and the United Kingdom, have now identified common risk factors that predispose to multiple even seemingly unrelated diseases.

22 Mar 2021

Male fertility and androgen production may be impacted by COVID-19

An interesting new study has appeared online in the journal Hormones that discusses the effects of COVID-19 on the male and female gonads.

22 Mar 2021

Blocking folate metabolism could reduce SARS-CoV-2 viral replication in infected cells

The novel beta-coronavirus virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and coronaviruses, in general, alter the host's cellular metabolism to support massive production of ~30 kB viral genomes and subgenomic viral RNAs. However, how this is achieved is largely unknown.

21 Mar 2021

Metabolites News and Research

Systematic review: Exposure to endocrine-disruptors could elevate breast cancer risk

New mathematical model could help design new probiotics and tailored diets to prevent diseases

Plant-derived compound isorhamnetin may have antiviral potential against SARS-CoV-2

S-2-hydroxyglutarate keeps endothelial cells in a dormant state, reveals study

Greater intake of red and processed meat associated with worse heart function, finds study

Small molecule inhibitors of SARS-CoV-2 identified by screening

Research offers an efficient approach to mine the chemical diversity of endophytic fungi

Gut microbiome communicates with horse’s cells to enhance their athletic performance

Prenatal exposure to phthalates is linked to altered cognitive outcomes in infants

New biomarker of glucocorticoid action could help clinicians to tailor treatments

Researchers offer large-scale screening of potential broad-spectrum SARS-CoV-2 antivirals

Metabolic dysfunction found in mouse models of neurodevelopmental disorders

Gestational exposure to environmental toxicants linked to autistic-like behaviors in children

Scientists describe the mechanisms that regulate embryonic stem cells

New technology to obtain 'protein fingerprints' in just a few minutes

Study uncovers new biomarkers in patients with malignant melanoma

COVID vaccines have only 17% detectable antibodies against SARS-CoV-2 virus

Study identifies metabolic processes associated with multiple, unrelated diseases

Male fertility and androgen production may be impacted by COVID-19

Blocking folate metabolism could reduce SARS-CoV-2 viral replication in infected cells

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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