Methotrexate News and Research

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Methotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.

Methotrexate is approved by the Food and Drug Administration (FDA) to be used by itself to treat the following types of gestational trophoblastic tumors, Chorioadenoma destruens, Choriocarcinoma, Hydatidiform mole. Methotrexate is also approved to be used alone or with other drugs to treat acute lymphoblastic leukemia (ALL) that has spread to the central nervous system (CNS) or to keep it from spreading there, and to treat the following, breast cancer, certain types of head and neck cancer, lung cancer, advanced non-Hodgkin lymphoma (NHL), advanced mycosis fungoides (a type of cutaneous T-cell lymphoma), osteosarcoma that has not spread to other parts of the body, following surgery to remove the primary tumor. Methotrexate is also approved to treat the following non-cancer conditions, rheumatoid arthritis, severe psoriasis.
Cardiovascular comobidities in RA patients

Cardiovascular comobidities in RA patients

Long-term consequences of COVID-19 in patients with inflammatory rheumatic diseases

Long-term consequences of COVID-19 in patients with inflammatory rheumatic diseases

Study shows the potential of TAp63 as a new therapeutic target for rheumatoid arthritis

Study shows the potential of TAp63 as a new therapeutic target for rheumatoid arthritis

Clinical trial findings may be a game changer in the treatment of pediatric Crohn's disease

Clinical trial findings may be a game changer in the treatment of pediatric Crohn's disease

Scientists find a good treatment target for pulmonary hypertension

Scientists find a good treatment target for pulmonary hypertension

Investigating the impact of COVID-19 vaccinations in immunocompromised adult patients

Investigating the impact of COVID-19 vaccinations in immunocompromised adult patients

Immunosuppressive drug methotrexate linked to increased risk of three types of skin cancer

Immunosuppressive drug methotrexate linked to increased risk of three types of skin cancer

Part II: The state of the abortion debate 50 years after ‘Roe’

Part II: The state of the abortion debate 50 years after ‘Roe’

Study analyzes the viability of new nanomolecule as drug delivery vehicle

Study analyzes the viability of new nanomolecule as drug delivery vehicle

Research suggests people on rheumatoid arthritis drugs show weaker response to SARS-CoV-2 vaccines

Research suggests people on rheumatoid arthritis drugs show weaker response to SARS-CoV-2 vaccines

Major treatment advance revealed for adults with newly diagnosed B lineage acute lymphoblastic leukemia

Major treatment advance revealed for adults with newly diagnosed B lineage acute lymphoblastic leukemia

Trial assesses the impact of two immunomodulators in reducing CV risk among rheumatoid arthritis patients

Trial assesses the impact of two immunomodulators in reducing CV risk among rheumatoid arthritis patients

Scientists report new target to combat coronary artery disease

Scientists report new target to combat coronary artery disease

OSU researchers develop novel nanomedicine technique for diagnosing and ending ectopic pregnancies

OSU researchers develop novel nanomedicine technique for diagnosing and ending ectopic pregnancies

Updated EULAR recommendations on the use of DMARDs for people with RA

Updated EULAR recommendations on the use of DMARDs for people with RA

Skipping methotrexate for one week after flu vaccine provides the same seroprotection as a two-week hold in RA patients

Skipping methotrexate for one week after flu vaccine provides the same seroprotection as a two-week hold in RA patients

What is the association of SARS-CoV-2 vaccination with the risk of PASC in patients with SARDs?

What is the association of SARS-CoV-2 vaccination with the risk of PASC in patients with SARDs?

$80,000 and 5 ER visits: An ectopic pregnancy takes a toll despite NY’s liberal abortion law

$80,000 and 5 ER visits: An ectopic pregnancy takes a toll despite NY’s liberal abortion law

Treating the cerebrospinal fluid to protect the brain from chemotherapy's toxic effects

Treating the cerebrospinal fluid to protect the brain from chemotherapy's toxic effects

Supplementary folic acid associated with higher risk of COVID-19 diagnosis and mortality

Supplementary folic acid associated with higher risk of COVID-19 diagnosis and mortality