Methotrexate News and Research

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Methotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.

Methotrexate is approved by the Food and Drug Administration (FDA) to be used by itself to treat the following types of gestational trophoblastic tumors, Chorioadenoma destruens, Choriocarcinoma, Hydatidiform mole. Methotrexate is also approved to be used alone or with other drugs to treat acute lymphoblastic leukemia (ALL) that has spread to the central nervous system (CNS) or to keep it from spreading there, and to treat the following, breast cancer, certain types of head and neck cancer, lung cancer, advanced non-Hodgkin lymphoma (NHL), advanced mycosis fungoides (a type of cutaneous T-cell lymphoma), osteosarcoma that has not spread to other parts of the body, following surgery to remove the primary tumor. Methotrexate is also approved to treat the following non-cancer conditions, rheumatoid arthritis, severe psoriasis.
Treating the cerebrospinal fluid to protect the brain from chemotherapy's toxic effects

Treating the cerebrospinal fluid to protect the brain from chemotherapy's toxic effects

Supplementary folic acid associated with higher risk of COVID-19 diagnosis and mortality

Supplementary folic acid associated with higher risk of COVID-19 diagnosis and mortality

The risk of adverse reactions when herbal medications are taken with cancer drugs

The risk of adverse reactions when herbal medications are taken with cancer drugs

Patients and doctors trapped in a gray zone when abortion laws and emergency care mandate conflict

Patients and doctors trapped in a gray zone when abortion laws and emergency care mandate conflict

RINVOQ® (upadacitinib) Approved by European Commission as an Oral Treatment for Adults with Active Non-Radiographic Axial Spondyloarthritis

RINVOQ® (upadacitinib) Approved by European Commission as an Oral Treatment for Adults with Active Non-Radiographic Axial Spondyloarthritis

Three things about the abortion debate that many people get wrong

Three things about the abortion debate that many people get wrong

UC San Francisco neurologists focus on the hazards of abortion restrictions for women of reproductive age

UC San Francisco neurologists focus on the hazards of abortion restrictions for women of reproductive age

Study identifies critical genes and biological pathways related to COVID-19 myocarditis

Study identifies critical genes and biological pathways related to COVID-19 myocarditis

After two ectopic pregnancies, I fear what might happen without Roe v. Wade

After two ectopic pregnancies, I fear what might happen without Roe v. Wade

SARS-CoV-2 infection may be a trigger of myelin oligodendrocyte glycoprotein-associated disorder

SARS-CoV-2 infection may be a trigger of myelin oligodendrocyte glycoprotein-associated disorder

Even mild respiratory COVID can affect the brain

Even mild respiratory COVID can affect the brain

Risk of severe COVID-19 in adults with immune-mediated inflammatory diseases and those on immune-modifying therapies

Risk of severe COVID-19 in adults with immune-mediated inflammatory diseases and those on immune-modifying therapies

People with inflammatory immune conditions had increased risk of COVID-19-related death before vaccination

People with inflammatory immune conditions had increased risk of COVID-19-related death before vaccination

Assessment of England's medication prescribing safety during COVID pandemic

Assessment of England's medication prescribing safety during COVID pandemic

COVID-19 may affect a group of biochemical reactions called one-carbon metabolism

COVID-19 may affect a group of biochemical reactions called one-carbon metabolism

Study: Many older adults are not prescribed disease-modifying drugs for rheumatoid arthritis

Study: Many older adults are not prescribed disease-modifying drugs for rheumatoid arthritis

New study analyzes COVID-19 outcomes in patients with cancer

New study analyzes COVID-19 outcomes in patients with cancer

Prescribing of ineffective COVID drugs could have been influenced by political affiliation

Prescribing of ineffective COVID drugs could have been influenced by political affiliation

Study suggests folic acid supplementation linked to increased risk for COVID-19 diagnosis

Study suggests folic acid supplementation linked to increased risk for COVID-19 diagnosis

Use of immunosuppressants for inflammatory rheumatic diseases and the associated risk of severe COVID-19

Use of immunosuppressants for inflammatory rheumatic diseases and the associated risk of severe COVID-19