Methotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.
Methotrexate is approved by the Food and Drug Administration (FDA) to be used by itself to treat the following types of gestational trophoblastic tumors, Chorioadenoma destruens, Choriocarcinoma, Hydatidiform mole. Methotrexate is also approved to be used alone or with other drugs to treat acute lymphoblastic leukemia (ALL) that has spread to the central nervous system (CNS) or to keep it from spreading there, and to treat the following, breast cancer, certain types of head and neck cancer, lung cancer, advanced non-Hodgkin lymphoma (NHL), advanced mycosis fungoides (a type of cutaneous T-cell lymphoma), osteosarcoma that has not spread to other parts of the body, following surgery to remove the primary tumor. Methotrexate is also approved to treat the following non-cancer conditions, rheumatoid arthritis, severe psoriasis.
Up to three quarters of patients receiving cancer chemotherapy suffer from "chemo brain" -; a long-term side effect that makes it harder to remember things, maintain attention, and learn new information. When it strikes children, whose brains are still developing, their schoolwork and self-esteem may suffer.
In a recent study published in the journal BMJ Open, researchers investigated the impact of folic acid supplements and methotrexate, in combination or individually, on disease severity and mortality in coronavirus disease 2019 (COVID-19) cases.
A new study discusses phytovigilance initiatives based on the real-world use of herbal drugs in cancer along with conventional chemotherapy.
Each week, Dr. Kim Puterbaugh sees several pregnant patients at a Cleveland hospital who are experiencing complications involving bleeding or infection.
With this approval, RINVOQ® is the first and only Janus Kinase inhibitor approved to treat patients across the spectrum of axial spondyloarthritis (nr-axSpA and ankylosing spondylitis) in the EU.
In the wake of the Supreme Court's decision to overturn the federal right to abortion, things are more than a little confused.
UCSF Perspective Article Says New Ruling May Result in Increased Risk of Deaths, Disability.
Scientists from China have recently deciphered the genetic network and biological mechanisms associated with COVID-19 myocarditis using bioinformatic methods.
I've been pregnant five times. I have one child. A son, Sam, who was born on his due date, weighing 6 pounds and 14 ounces, in 1997.
A new study reported four cases of Myelin Oligodendrocyte Glycoprotein-Associated Disorder that commenced after SARS-CoV-2 infection.
In a recent study published in the journal Cell, researchers explored neurological symptoms and subsequent cognitive impairment experienced by survivors of mild respiratory coronavirus disease 2019 (COVID-19).
Researchers assessed the risk of severe COVID-19 in adults with immune-mediated inflammatory diseases and those on immunomodulatory therapies.
People with certain inflammatory immune conditions affecting the joints, bowel and skin, such as rheumatoid arthritis, may have been more at risk of dying or needing hospital care if they got COVID-19 before vaccination compared with the general population, according to a new study published in The Lancet Rheumatology.
In a recent study posted to the medRxiv* preprint server, researchers assessed the impact of coronavirus disease 2019 (COVID-19) on the prescribing safety of high-risk medications on a national scale in England.
A new study addresses the relationship between SARS-CoV-2 to the metabolism of one-carbon molecules in the host, suggesting new therapeutic pathways.
Despite guidelines that call for early and aggressive treatment of rheumatoid arthritis, a new study suggests many older adults are not prescribed disease-modifying medications for their inflammatory autoimmune disease.
If a cancer patient tests positive for COVID-19, are they more likely to become hospitalized from the disease?
Two treatments that have been shown to be ineffective against COVID-19—hydroxychloroquine and ivermectin—were more heavily prescribed in the latter part of 2020 in U.S. counties with a higher Republican vote share in the 2020 presidential election, according to a new research letter co-authored by researchers from Harvard T.H. Chan School of Public Health.
In a recent study posted to the medRxiv* preprint server, researchers evaluated if folic acid or methotrexate use impacts the risk of coronavirus disease 2019 (COVID-19) diagnosis or associated mortality in the United Kingdom (UK).
A recent study posted to the medRxiv* preprint server investigated the risk of severe/fatal coronavirus disease 2019 (COVID-19) in patients treated with immunosuppressants for inflammatory rheumatic diseases (IRD).