Methotrexate News and Research

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Methotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.

Methotrexate is approved by the Food and Drug Administration (FDA) to be used by itself to treat the following types of gestational trophoblastic tumors, Chorioadenoma destruens, Choriocarcinoma, Hydatidiform mole. Methotrexate is also approved to be used alone or with other drugs to treat acute lymphoblastic leukemia (ALL) that has spread to the central nervous system (CNS) or to keep it from spreading there, and to treat the following, breast cancer, certain types of head and neck cancer, lung cancer, advanced non-Hodgkin lymphoma (NHL), advanced mycosis fungoides (a type of cutaneous T-cell lymphoma), osteosarcoma that has not spread to other parts of the body, following surgery to remove the primary tumor. Methotrexate is also approved to treat the following non-cancer conditions, rheumatoid arthritis, severe psoriasis.
RA guidelines stress on minimizing steroids and maximizing methotrexate, biologics

RA guidelines stress on minimizing steroids and maximizing methotrexate, biologics

Oral methotrexate can be an effective intervention for people with knee OA

Oral methotrexate can be an effective intervention for people with knee OA

TB screening needed for people on methotrexate who live in at-risk areas

TB screening needed for people on methotrexate who live in at-risk areas

Methotrexate is not an additional risk factor for interstitial lung disease in RA patients

Methotrexate is not an additional risk factor for interstitial lung disease in RA patients

Early intensive treatment of rheumatoid arthritis offers an opportunity to manage fatigue

Early intensive treatment of rheumatoid arthritis offers an opportunity to manage fatigue

New treatment may improve the quality of life for patients with mesothelioma

New treatment may improve the quality of life for patients with mesothelioma

Researchers identify a novel mechanism of chemoresistance

Researchers identify a novel mechanism of chemoresistance

People suffering from rheumatoid arthritis with increased disease activity have high thrombosis risk

People suffering from rheumatoid arthritis with increased disease activity have high thrombosis risk

EULAR publishes updated recommendations for treating people with psoriatic arthritis

EULAR publishes updated recommendations for treating people with psoriatic arthritis

Finding new therapeutic strategies for aggressive T-cell acute lymphoblastic leukemia

Finding new therapeutic strategies for aggressive T-cell acute lymphoblastic leukemia

AGA publishes new COVID-19 guidance for gastroenterologists treating patients with IBD

AGA publishes new COVID-19 guidance for gastroenterologists treating patients with IBD

Nanopore reveals shape-shifting enzyme linked to catalysis

Nanopore reveals shape-shifting enzyme linked to catalysis

Cream infused with microscopic STAR particles could facilitate better treatment of skin diseases

Cream infused with microscopic STAR particles could facilitate better treatment of skin diseases

Updated guideline for management of osteoarthritis of the hand, hip and knee released

Updated guideline for management of osteoarthritis of the hand, hip and knee released

Juvenile immune arthritis – new treatments wanted

Juvenile immune arthritis – new treatments wanted

Methotrexate reduces joint damage in hand osteoarthritis

Methotrexate reduces joint damage in hand osteoarthritis

Study compares ultrasound versus conventional strategies in early rheumatoid arthritis

Study compares ultrasound versus conventional strategies in early rheumatoid arthritis

Cancer patients with RA treated with immune checkpoint inhibitors likely to experience a flare

Cancer patients with RA treated with immune checkpoint inhibitors likely to experience a flare

Methotrexate appears to facilitate bone remodeling in patients with osteoarthritis

Methotrexate appears to facilitate bone remodeling in patients with osteoarthritis

Optimal therapy for Down syndrome arthropathy remains unclear, reveals study

Optimal therapy for Down syndrome arthropathy remains unclear, reveals study