Methotrexate News and Research

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Methotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.

Methotrexate is approved by the Food and Drug Administration (FDA) to be used by itself to treat the following types of gestational trophoblastic tumors, Chorioadenoma destruens, Choriocarcinoma, Hydatidiform mole. Methotrexate is also approved to be used alone or with other drugs to treat acute lymphoblastic leukemia (ALL) that has spread to the central nervous system (CNS) or to keep it from spreading there, and to treat the following, breast cancer, certain types of head and neck cancer, lung cancer, advanced non-Hodgkin lymphoma (NHL), advanced mycosis fungoides (a type of cutaneous T-cell lymphoma), osteosarcoma that has not spread to other parts of the body, following surgery to remove the primary tumor. Methotrexate is also approved to treat the following non-cancer conditions, rheumatoid arthritis, severe psoriasis.
Finding which chemotherapy regimen is associated with best outcomes for patients with bladder cancer

Finding which chemotherapy regimen is associated with best outcomes for patients with bladder cancer

New study highlights predictors that prevent from achieving remission in early RA

New study highlights predictors that prevent from achieving remission in early RA

Researchers uncover racial differences in debilitating itchy skin condition

Researchers uncover racial differences in debilitating itchy skin condition

Study: Early, intensive treatment of rheumatoid arthritis has long-term benefits

Study: Early, intensive treatment of rheumatoid arthritis has long-term benefits

New treatment regimen boosts survival for young adults and children with T-cell malignancies

New treatment regimen boosts survival for young adults and children with T-cell malignancies

Leukemia itself may increase risk for long-term neurocognitive problems in survivors

Leukemia itself may increase risk for long-term neurocognitive problems in survivors

Drug improves disease-free, overall survival after hematopoietic stem cell transplants

Drug improves disease-free, overall survival after hematopoietic stem cell transplants

‘Chemo brain’ may start as tumors form and develop, suggests study

‘Chemo brain’ may start as tumors form and develop, suggests study

Old World monkeys could hold key to stop progression of rheumatoid arthritis

Old World monkeys could hold key to stop progression of rheumatoid arthritis

Analysis finds simple method to identify patients most likely to benefit from long-term canakinumab treatment

Analysis finds simple method to identify patients most likely to benefit from long-term canakinumab treatment

Opioid and antidepressant use related to increased risk of osteoporotic fractures for RA patients

Opioid and antidepressant use related to increased risk of osteoporotic fractures for RA patients

Excess weight linked to higher degree of synovitis in RA patients

Excess weight linked to higher degree of synovitis in RA patients

Juvenile idiopathic arthritis affects more than 300,000 children in the U.S.

Juvenile idiopathic arthritis affects more than 300,000 children in the U.S.

Component of fire ant venom shows promise as a psoriasis treatment

Component of fire ant venom shows promise as a psoriasis treatment

Anti-inflammatory therapy reduces incidence of lung cancer

Anti-inflammatory therapy reduces incidence of lung cancer

Studies reveal strategies for using shingles vaccine in arthritis patients

Studies reveal strategies for using shingles vaccine in arthritis patients

Sheffield scientists discover that simple arthritis drug could help treat blood cancer sufferers

Sheffield scientists discover that simple arthritis drug could help treat blood cancer sufferers

Existing drugs could offer new way to treat severe inflammatory skin conditions

Existing drugs could offer new way to treat severe inflammatory skin conditions

Harris Health System expert offers guidance to prevent drug-induced photosensitivity

Harris Health System expert offers guidance to prevent drug-induced photosensitivity

Immunotherapy found to be smarter, kinder treatment for people with head and neck cancer

Immunotherapy found to be smarter, kinder treatment for people with head and neck cancer