Methotrexate News and Research

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Methotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.

Methotrexate is approved by the Food and Drug Administration (FDA) to be used by itself to treat the following types of gestational trophoblastic tumors, Chorioadenoma destruens, Choriocarcinoma, Hydatidiform mole. Methotrexate is also approved to be used alone or with other drugs to treat acute lymphoblastic leukemia (ALL) that has spread to the central nervous system (CNS) or to keep it from spreading there, and to treat the following, breast cancer, certain types of head and neck cancer, lung cancer, advanced non-Hodgkin lymphoma (NHL), advanced mycosis fungoides (a type of cutaneous T-cell lymphoma), osteosarcoma that has not spread to other parts of the body, following surgery to remove the primary tumor. Methotrexate is also approved to treat the following non-cancer conditions, rheumatoid arthritis, severe psoriasis.
Still-to-be-approved drug proves to be new option for treating active rheumatoid arthritis

Still-to-be-approved drug proves to be new option for treating active rheumatoid arthritis

Surgery can be beneficial for one type of primary central nervous system lymphoma

Surgery can be beneficial for one type of primary central nervous system lymphoma

ACR and Arthritis Foundation release two guidelines on juvenile idiopathic arthritis

ACR and Arthritis Foundation release two guidelines on juvenile idiopathic arthritis

Promising new way to thwart tricky Mtb pathogen

Promising new way to thwart tricky Mtb pathogen

Machine learning tool could prevent unnecessary treatments for kids with arthritis

Machine learning tool could prevent unnecessary treatments for kids with arthritis

New discovery can explain resistance of cancer types to fatty acid metabolism inhibition

New discovery can explain resistance of cancer types to fatty acid metabolism inhibition

Monoclonal antibody pembrolizumab prolongs survival in patients with squamous cell carcinoma

Monoclonal antibody pembrolizumab prolongs survival in patients with squamous cell carcinoma

Inexpensive and effective drug does not reduce major adverse cardiovascular event rates

Inexpensive and effective drug does not reduce major adverse cardiovascular event rates

Atopic dermatitis found to be highly prevalent among adults in the U.S.

Atopic dermatitis found to be highly prevalent among adults in the U.S.

Toxic effects of drugs in the lungs 'more widespread than thought'

Toxic effects of drugs in the lungs 'more widespread than thought'

FDA approves update to Rituxan label to include information on treatment of rare forms of vasculitis

FDA approves update to Rituxan label to include information on treatment of rare forms of vasculitis

Finding which chemotherapy regimen is associated with best outcomes for patients with bladder cancer

Finding which chemotherapy regimen is associated with best outcomes for patients with bladder cancer

New study highlights predictors that prevent from achieving remission in early RA

New study highlights predictors that prevent from achieving remission in early RA

Researchers uncover racial differences in debilitating itchy skin condition

Researchers uncover racial differences in debilitating itchy skin condition

Study: Early, intensive treatment of rheumatoid arthritis has long-term benefits

Study: Early, intensive treatment of rheumatoid arthritis has long-term benefits

New treatment regimen boosts survival for young adults and children with T-cell malignancies

New treatment regimen boosts survival for young adults and children with T-cell malignancies

Leukemia itself may increase risk for long-term neurocognitive problems in survivors

Leukemia itself may increase risk for long-term neurocognitive problems in survivors

Drug improves disease-free, overall survival after hematopoietic stem cell transplants

Drug improves disease-free, overall survival after hematopoietic stem cell transplants

‘Chemo brain’ may start as tumors form and develop, suggests study

‘Chemo brain’ may start as tumors form and develop, suggests study

Old World monkeys could hold key to stop progression of rheumatoid arthritis

Old World monkeys could hold key to stop progression of rheumatoid arthritis