Methotrexate News and Research

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Methotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.

Methotrexate is approved by the Food and Drug Administration (FDA) to be used by itself to treat the following types of gestational trophoblastic tumors, Chorioadenoma destruens, Choriocarcinoma, Hydatidiform mole. Methotrexate is also approved to be used alone or with other drugs to treat acute lymphoblastic leukemia (ALL) that has spread to the central nervous system (CNS) or to keep it from spreading there, and to treat the following, breast cancer, certain types of head and neck cancer, lung cancer, advanced non-Hodgkin lymphoma (NHL), advanced mycosis fungoides (a type of cutaneous T-cell lymphoma), osteosarcoma that has not spread to other parts of the body, following surgery to remove the primary tumor. Methotrexate is also approved to treat the following non-cancer conditions, rheumatoid arthritis, severe psoriasis.
Study analyzes uveitis risk after antirheumatic drug withdrawal in children with arthritis

Study analyzes uveitis risk after antirheumatic drug withdrawal in children with arthritis

Methotrexate users fail to achieve adequate immune response to mRNA COVID-19 vaccines

Methotrexate users fail to achieve adequate immune response to mRNA COVID-19 vaccines

People taking anti-inflammatory drug mount a weaker immune response to COVID-19 vaccine

People taking anti-inflammatory drug mount a weaker immune response to COVID-19 vaccine

Effect of COVID-19 pandemic on patients with rheumatoid arthritis, systemic lupus erythematosus

Effect of COVID-19 pandemic on patients with rheumatoid arthritis, systemic lupus erythematosus

Methotrexate impairs immunogenicity of BNT162b2 SARS-CoV-2 vaccine in patients with immune-mediated inflammatory diseases

Methotrexate impairs immunogenicity of BNT162b2 SARS-CoV-2 vaccine in patients with immune-mediated inflammatory diseases

Commonly-prescribed drug for IBD blunts COVID-19 vaccine response

Commonly-prescribed drug for IBD blunts COVID-19 vaccine response

Does natural infection with SARS-CoV-2 offer more protection than a vaccine against new variants?

Does natural infection with SARS-CoV-2 offer more protection than a vaccine against new variants?

Targeting microRNAs makes cancer stem cells more susceptible to chemotherapies

Targeting microRNAs makes cancer stem cells more susceptible to chemotherapies

Study explains the link between psoriasis treatment and cardiovascular diseases

Study explains the link between psoriasis treatment and cardiovascular diseases

Blocking folate metabolism could reduce SARS-CoV-2 viral replication in infected cells

Blocking folate metabolism could reduce SARS-CoV-2 viral replication in infected cells

Two-drug combination approach could be effective against bone cancer

Two-drug combination approach could be effective against bone cancer

Study reveals how ecDNA fragments drive gene amplification to generate drug resistance in cancer

Study reveals how ecDNA fragments drive gene amplification to generate drug resistance in cancer

Researchers discover how shattered chromosomes make cancer cells more aggressive

Researchers discover how shattered chromosomes make cancer cells more aggressive

Targeted Therapies Alliance provides new information, resources about the rheumatoid arthritis journey

Targeted Therapies Alliance provides new information, resources about the rheumatoid arthritis journey

Researchers analyze outcomes in patients with primary central nervous system lymphoma

Researchers analyze outcomes in patients with primary central nervous system lymphoma

Chemotherapy combined with blinatumomab increases survival for patients with Ph-negative B-ALL

Chemotherapy combined with blinatumomab increases survival for patients with Ph-negative B-ALL

Clinical investigators present abstracts on hematological malignancies at ASH Annual Meeting and Exposition

Clinical investigators present abstracts on hematological malignancies at ASH Annual Meeting and Exposition

RA guidelines stress on minimizing steroids and maximizing methotrexate, biologics

RA guidelines stress on minimizing steroids and maximizing methotrexate, biologics

Oral methotrexate can be an effective intervention for people with knee OA

Oral methotrexate can be an effective intervention for people with knee OA

TB screening needed for people on methotrexate who live in at-risk areas

TB screening needed for people on methotrexate who live in at-risk areas