MicroRNA News and Research

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In genetics, microRNAs (miRNA) are single-stranded RNA molecules of 21-23 nucleotides in length, which regulate gene expression. miRNAs are encoded by genes from whose DNA they are transcribed but miRNAs are not translated into protein (i.e. they are non-coding RNAs); instead each primary transcript (a pri-miRNA) is processed into a short stem-loop structure called a pre-miRNA and finally into a functional miRNA. Mature miRNA molecules are partially complementary to one or more messenger RNA (mRNA) molecules, and their main function is to down-regulate gene expression.

Alnylam Pharmaceuticals publishes ALN-RSV01 Phase IIa study results

Alnylam Pharmaceuticals, Inc. a leading RNAi therapeutics company announced today that it has published results in the American Journal of Respiratory and Critical Care Medicine from its double-blind, placebo-controlled, randomized Phase IIa study of ALN-RSV01 in lung transplant patients naturally infected with respiratory syncytial virus (RSV).

30 Sep 2010

Omicsoft's Next Generation Sequencing tools integrated with GeneGo's MetaCore data mining suite

GeneGo, Inc., the leading systems biology tools company and Omicsoft Corporation, the leader in the OMIC repository and analysis field, announced today integration of Omicsoft's Next Generation Sequencing tools with GeneGo's MetaCore data mining suite.

29 Sep 2010

microRNA may provide quick diagnosis of bladder cancer

Scientists may have discovered a way to diagnose bladder cancer at its earliest and, therefore, most treatable stages by measuring the presence or absence of microRNA using already available laboratory tests.

29 Sep 2010

Scientists discover way of shrinking tumours in cancers

Australian and American scientists have found a way of shrinking tumours in certain cancers - a finding that provides hope for new treatments.

29 Sep 2010

Tel Aviv researchers develop innovative software to analyze and manipulate diseased cells

About ten years ago, the discovery of microRNAs ― tiny cellular molecules that regulate our genetic code ― unlocked a world of scientific possibilities, including a deeper understanding of human disease. One new analytical technology is "deep sequencing," which gives scientists the ability to discover invaluable information about human diseases at a genetic level.

28 Sep 2010

Six Chicago high school students win CAP's 2010 'Path to a Future in Medicine' award

The College of American Pathologists (CAP) awarded six Chicago high school students the College's 2010 "Path to a Future in Medicine" award.

24 Sep 2010

Asuragen announces results of study evaluating RNA-based assay for detection of common NPM1 mutations

Asuragen, Inc. announced today the results of a collaborative study with scientists at Johns Hopkins University School of Medicine evaluating a RNA-based assay for the rapid, sensitive and multiplex detection of common NPM1 mutations. The study results were published in the September issue of the Journal of Molecular Diagnostics.

23 Sep 2010

NIDA awards GeneGo SBIR grant to develop integrated systems biology platform for nicotine addiction research

GeneGo, Inc., the leading systems biology company, today announced that it has been awarded a grant from the National Institute on Drug Abuse to develop an integrated systems biology platform for research into the causes and treatment of tobacco dependence, nicotine addiction, smoking cessation and tobacco/nicotine withdrawal.

22 Sep 2010

Santaris Pharma paves way to conduct clinical trial of miravirsen in patients with HVC

Santaris Pharma A/S, a clinical-stage biopharmaceutical company focused on the discovery and development of RNA-targeted therapies, today announced that it has advanced miravirsen (SPC3649), the first microRNA-targeted drug to enter clinical trials, into Phase 2 studies to assess the safety and tolerability of the drug in treatment-naive patients infected with the Hepatitis C virus.

22 Sep 2010

AACR to host fourth International Conference on Molecular Diagnostics

The American Association for Cancer Research will host its Fourth AACR International Conference on Molecular Diagnostics in Cancer Therapeutic Development from Sept. 27-30, 2010, at the Sheraton Denver Downtown in Denver, Colo.

22 Sep 2010

Blood vessel growth promoting microRNA predicts diabetes: Study

For the first time, scientists have found that blood levels of some ribonucleic acids (microRNAs) are different among people with type 2 diabetes and those who subsequently develop the disease compared to healthy controls, according to research reported in Circulation Research: Journal of the American Heart Association.

17 Sep 2010

Researchers reveal Prozac reactions to increase serotonin level

The response time to antidepressants, such as Prozac, is around three weeks. The adaptation mechanisms of the neurons to antidepressants has, until now, remained enigmatic. In particular, the researchers have revealed, for the first time, a sequence of reactions caused by Prozac at the neuron level, which contributes to an increase in the amounts of serotonin, a chemical "messenger" essential to the brain, and deficient in depressive individuals.

17 Sep 2010

Sistemic introduces SistemQC services to monitor cells

Sistemic Ltd., the fast growing UK life sciences company, today launched their patented SistemQC services for researchers and industry. SistemQC monitors cells including stem cell populations for intended or unintended change using biologically defined measures. These new product additions will support faster decision making for cell manufacturers at critical QC points within their process workflows.

15 Sep 2010

Norgen Biotek launches three novel kits for urine sampling

Norgen Biotek Corp, a privately held Canadian biotechnology company focusing principally on advancing a powerful proprietary technology for application in sample preparation for nucleic acid (DNA, RNA and microRNA) and protein purification, today announced the expansion of its basket of urine-based sample preparation products by launching 3 new urine concentration, preservation and isolation kits.

15 Sep 2010

microRNA 451 enhances treatment response in stomach cancer patients: Research

"The high presence of microRNA 451 enhances the response to treatment with chemo-radiotherapy and increases the survival of patients with stomach cancer", explained Dr. Jesús García-Foncillas, chief researcher of the Pharmacogenomics Laboratory at the Applied Medical Research Centre (CIMA) and Director of Oncology at the University Hospital of Navarra. This was one of the results presented at the IV Congress of the Spanish Society for Pharmacogenetics and Pharmacogenomic, recently held at CIMA.

15 Sep 2010

Molecule microRNA-21 enhances growth and survival of existing lung cancer

A tiny molecule that spurs the progression of non-small-cell lung cancer could become a player in fighting the disease, say researchers at UT Southwestern Medical Center, who published a study on how the molecule behaves in mice in the Sept. 14 issue of Cancer Cell.

14 Sep 2010

Mipomersen Phase 3 trial in heFH meets primary, secondary and tertiary endpoints

Genzyme Corp. and Isis Pharmaceuticals Inc. announced that data from the phase 3 study of mipomersen in patients with heterozygous familial hypercholesterolemia (heFH) were presented today at the European Society of Cardiology's Congress 2010 in Stockholm, Sweden. The study met its primary endpoint with a 28 percent reduction in LDL-cholesterol, compared with an increase of 5 percent for placebo (p<0.001). The trial also met all of its secondary and tertiary endpoints.

2 Sep 2010

Asuragen launches KRAS, BRAF mutational testing in CLIA laboratory

Asuragen, Inc., a leader in molecular diagnostics and nucleic acid-based pharmacogenomics services, announced today that it has launched KRAS and BRAF mutational testing services in its CAP-accredited CLIA laboratory.

2 Sep 2010

Jefferson scientists receive grant to study genetics of platelet gene expression

Scientists at Jefferson Medical College have received a four-year, $3 million National Institutes of Health grant funded by the National Heart, Lung and Blood Institute to study variations of platelet function, specifically, the genetics of platelet gene expression. The study aims to find data that can be translated into novel therapeutic strategies and develop better predictors of cardiovascular disease.

30 Aug 2010

Agilent Technologies introduces SureSelect Human All Exon v2 Target Enrichment kit for cancer assay

Agilent Technologies Inc.today introduced the SureSelect Human All Exon v2 Target Enrichment kit, which was developed in close collaboration with the Broad Institute of MIT and Harvard. The kit, the 15th SureSelect product in Agilent's portfolio, is a single tube assay that allows researchers to streamline experiments by sequencing the expressed genome while discarding regions not of interest.

25 Aug 2010

MicroRNA News and Research

Further Reading

Alnylam Pharmaceuticals publishes ALN-RSV01 Phase IIa study results

Omicsoft's Next Generation Sequencing tools integrated with GeneGo's MetaCore data mining suite

microRNA may provide quick diagnosis of bladder cancer

Scientists discover way of shrinking tumours in cancers

Tel Aviv researchers develop innovative software to analyze and manipulate diseased cells

Six Chicago high school students win CAP's 2010 'Path to a Future in Medicine' award

Asuragen announces results of study evaluating RNA-based assay for detection of common NPM1 mutations

NIDA awards GeneGo SBIR grant to develop integrated systems biology platform for nicotine addiction research

Santaris Pharma paves way to conduct clinical trial of miravirsen in patients with HVC

AACR to host fourth International Conference on Molecular Diagnostics

Blood vessel growth promoting microRNA predicts diabetes: Study

Researchers reveal Prozac reactions to increase serotonin level

Sistemic introduces SistemQC services to monitor cells

Norgen Biotek launches three novel kits for urine sampling

microRNA 451 enhances treatment response in stomach cancer patients: Research

Molecule microRNA-21 enhances growth and survival of existing lung cancer

Mipomersen Phase 3 trial in heFH meets primary, secondary and tertiary endpoints

Asuragen launches KRAS, BRAF mutational testing in CLIA laboratory

Jefferson scientists receive grant to study genetics of platelet gene expression

Agilent Technologies introduces SureSelect Human All Exon v2 Target Enrichment kit for cancer assay

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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