MicroRNA News and Research

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In genetics, microRNAs (miRNA) are single-stranded RNA molecules of 21-23 nucleotides in length, which regulate gene expression. miRNAs are encoded by genes from whose DNA they are transcribed but miRNAs are not translated into protein (i.e. they are non-coding RNAs); instead each primary transcript (a pri-miRNA) is processed into a short stem-loop structure called a pre-miRNA and finally into a functional miRNA. Mature miRNA molecules are partially complementary to one or more messenger RNA (mRNA) molecules, and their main function is to down-regulate gene expression.

New method detects microRNA targets at the level of single cells

MicroRNAs are small molecules that regulate gene activity by binding to and destroying RNAs produced by the genes.

21 Sep 2023

New device can help test treatments in patients with gliomas

The shape and size of a grain of rice, the new device can conduct dozens of experiments at once to study the effects of new treatments on some of the hardest-to-treat brain cancers.

7 Sep 2023

New cancer therapy shows promise in mouse models, slows or reverses tumor growth

A new cancer therapy developed by Purdue University researchers attacks tumors by tricking cancer cells into absorbing a snippet of RNA that naturally blocks cell division.

4 Sep 2023

New insights into the role of liver progenitor cells in liver cancer initiation

Primary liver cancers ranked as the sixth most commonly diagnosed cancers and the third leading cause of cancer-related death in 2020. Among all primary liver cancers, HCC is the most common cancer, accounting for more than 80% of cases with a 5-year survival rate of less than 10% in Western countries.

17 Aug 2023

The role of self-extracellular nucleic acids in neuroinflammation

Researchers explore the role of self-extracellular nucleic acids in diseases like stroke, multiple sclerosis, Alzheimer’s disease, and Parkinson’s disease.

14 Aug 2023

SARS-CoV-2 induces mitochondrial dysfunction in multiple organs

Since the beginning of the COVID-19 pandemic caused by the SARS-CoV-2 virus, researchers have been trying to determine why this virus creates such negative long-term effects compared with most coronaviruses.

9 Aug 2023

How effective is physical activity in alleviating obesity-related inflammation in diabetes?

Scientists determine whether physical activity can be used as an effective intervention to mitigate obesity-related inflammation in diabetes.

1 Aug 2023

Single target, multiple possibilities: microRNA holds promise for epilepsy treatment

Study investigated the role of micro-ribonucleic acid (miRNA) miR-335-5p as a potential therapeutic target for epilepsy.

25 Jul 2023

Study finds cell-free RNA can be used to predict preeclampsia

Preeclampsia is a serious pregnancy disorder, marked by high blood pressure and the presence of proteins in urine, affecting between 2% and 4% of pregnant women worldwide, leading to about 46,000 maternal deaths and about 500,000 fetal and newborn deaths each year.

20 Jul 2023

Researchers create a multiclass cancer diagnostic model using miRNA expression profiles and AI

Cancer is one of the most devastating diseases in the world. In 2023, more than 1.9 million new cancer cases and 609,820 deaths are projected to occur in the United States alone.

20 Jul 2023

Study reveals potential target for repairing beta-cell dysfunction in Type 2 diabetes

Researchers used a murine model to demonstrate that functional excision of murine PITPNA eventually led to hyperglycemia in mice.

19 Jul 2023

Zebrafish study reveals how blood stem cells affect health

All humans have a diverse set of blood stem cell types which dictate the composition and function of our blood and immune cells and ultimately help govern overall health.

17 Jul 2023

Children with mitochondrial disorders have weaker antibody response to viral infections, study finds

In a new study, National Institutes of Health (NIH) researchers found that altered B cell function in children with mitochondrial disorders led to a weaker and less diverse antibody response to viral infections.

7 Jul 2023

Illuminating how children inherit parents’ stressful experiences

Most of us learned in high school that people get half their genes from their father and half from their mother. That's true, but it turns out the way parents contribute to their offspring's genetics is more complicated—and more intriguing.

27 Jun 2023

Fine-tuning cell mechanics stimulates hair growth: Study

Just as people's joints can get stiff as they age and make it harder for them to move around, hair follicle stem cells also get stiff, making it harder for them to grow hair, reports a new Northwestern Medicine study.

6 Jun 2023

New review unravels phthalates’ role in heart disease

Researchers review existing data on the impact of phthalate exposure on cardiovascular health.

25 May 2023

Curcumin can suppress metastasis of colorectal cancer cells by activating a specific signaling pathway

LMU researchers have identified a signaling pathway via which curcumin can suppress the metastasis of colorectal cancer cells.

25 May 2023

Fatty liver promotes the spread of colorectal cancer to the liver

Investigators at Cedars-Sinai Cancer found that fatty liver, a condition closely associated with obesity, promotes the spread of colorectal cancer to the liver.

11 May 2023

Researchers evaluate the dual-therapeutic effect of gene therapy in mouse model of osteosarcoma

Investigators at Brigham and Women’s Hospital and collaborating institutions evaluated the dual-therapeutic effect of gene therapy in a clinically relevant model for common form of bone cancer.

8 May 2023

Heart Failure 2023 covers the entire spectrum of heart failure

Get ready for state-of-the-art discussions on new and emerging methods for heart failure management at Heart Failure 2023, a scientific congress of the European Society of Cardiology.

3 May 2023