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New model paves way to understanding and preventing SUDEP in familial epilepsy

Researchers at the University of Michigan have developed a model for studying one type of familial epilepsy, opening the door to understanding—and eventually targeting—the mechanisms that lead to the disorder and its associated fatalities.

25 Sep 2023

Researchers develop new protocol to study white matter injury in Alzheimer's disease

A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 16, entitled, "Microvascular contributions to white matter injury in Alzheimer's disease."

13 Sep 2023

Aging reorganizes pancreas circadian transcriptome

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 16, entitled, "Reorganization of pancreas circadian transcriptome with aging."

5 Sep 2023

Could a new framework for aging biomarkers revolutionize how we understand and treat the aging process?

A comprehensive review in the journal Cell outlines a unified framework for classifying and validating aging biomarkers, aiming to streamline their integration into clinical research and practice. The study categorizes biomarkers into types like molecular, functional, and clinical, and sets criteria for their feasibility, validity, and applicability, all with the goal of better understanding and intervening in the aging process.

5 Sep 2023

Dectin-1 stimulation promotes pro-inflammatory response in HIV-positive individuals

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 16, entitled, "Dectin-1 stimulation promotes a distinct inflammatory signature in the setting of HIV-infection and aging."

31 Aug 2023

Healthy aging can be achieved by optimizing diet at an early stage in life

Researchers at the Babraham Institute are proposing an alternative link between diet and aging based on studies in yeast.

29 Aug 2023

Study opens the door to new treatments for bone regeneration and osteoporosis

A new study of the PhyloBone project of the University of Turku, Finland, identifies hundreds of non-collagenous proteins in the bone matrix that may play regulatory roles in bone formation and regeneration.

17 Aug 2023

Klotho levels and telomere length may be associated through a coordinated downregulation of longevity factors

A new research paper was published by Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) in Volume 15, Issue 15, entitled, "Associations between klotho and telomere biology in high stress caregivers."

17 Aug 2023

NLRP3 inflammasome plays a role in podocyte aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, "Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span."

8 Aug 2023

Human senescent fibroblasts trigger fibrogenic reaction in the lungs of immunodeficient mice

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, "Human senescent fibroblasts trigger progressive lung fibrosis in mice."

31 Jul 2023

Positive experiences can reverse cognitive decline in old age

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 13, entitled, "MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan."

26 Jul 2023

Researchers discover new way to target bacterial cell wall

The bacterial cell wall must be constantly remodeled in order to grow and divide. This involves the close coordination of lytic enzymes and peptidoglycan synthesis.

20 Jul 2023

BUB1 protein and its kinase activity may regulate EGFR activation

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 13, entitled, "Budding uninhibited by benzimidazoles-1 (BUB1) regulates EGFR signaling by reducing EGFR internalization."

18 Jul 2023

Insilico Medicine and MIKADO team up to find new treatments for cystinosis

A team led by researchers at the Mechanisms of Inherited Kidney Disorders (MIKADO) group at the University of Zurich (Zurich, Switzerland) has used Insilico Medicine's generative artificial intelligence (AI) target discovery engine, PandaOmics, to identify actionable drug targets for the lysosomal storage disease cystinosis and to validate them in preclinical models of the disease.

14 Jul 2023

AI-powered drug discovery offers hope for cystinosis patients

Artificial intelligence is becoming increasingly important in drug discovery. Advances in the use of Big Data, learning algorithms and powerful computers have now enabled researchers at the University of Zurich (UZH) to better understand a serious metabolic disease.

14 Jul 2023

MemTrax continuous recognition test shows promise in early detection of Alzheimer's disease

A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 12, entitled, "Advancing screening for cognitive impairment: the memtrax continuous recognition test."

13 Jul 2023

Researchers develop a chemical approach to reverse aging

In a groundbreaking study, researchers have unlocked a new frontier in the fight against aging and age-related diseases.

12 Jul 2023

Mouse model of Hutchinson-Gilford progeria syndrome shows reduction in hepatic H2S levels

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 12, entitled, "Hepatic hydrogen sulfide levels are reduced in mouse model of Hutchinson-Gilford progeria syndrome."

11 Jul 2023

Novel peptide T14 levels may be an indicator of skin age and photo-aging

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 12, entitled, "A novel peptide 'T14' reflects age and photo-aging in human skin."

5 Jul 2023

Combining proteomic and miRNA data yields superior age predictions, study suggests

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 12, entitled, "Age prediction from human blood plasma using proteomic and small RNA data: a comparative analysis."

30 Jun 2023