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CLAMP: A newly discovered protein that regulates genes

They say a good man is hard to find. Were it not for a newly discovered protein, the X chromosome of a male fruit fly could never be found by a gene-regulating complex that male flies need to develop and survive. And that case is just one example of what the new finding means. More generally, the research provides biologists with a model of how proteins that govern gene transcription find their targets on chromosomes, a process that's essential to healthy cell function and sometimes implicated in disease.

22 Jul 2013

Structural properties have changed across bacterial families without putting limits on antibiotic resistance

Antibiotic-resistant bacteria have been emerging at an alarming rate. In some of the scariest of these pathogens, the mechanism responsible for the bacteria's ability to defeat antibiotics is a complex protein molecule embedded in the bacterial cell wall -- the enzyme β-lactamase.

20 Jul 2013

Researchers visualize live cell-to-cell communication pathways in bacteria

Most bacteria are able to communicate with each other by secreting signaling molecules. Once the concentration of signals has reached a critical density (-the Quorum), the bacteria are able to coordinate their behavior

20 Jul 2013

Scientists take important step toward pharmacologic development of treatment for fatal brain disorders

A team of researchers from Case Western Reserve University School of Medicine have identified a mechanism that can prevent the normal prion protein from changing its molecular shape into the abnormal form responsible for neurodegenerative diseases. This finding, published in the July 18 issue of Cell Reports, offers new hope in the battle against a foe that until now has always proved fatal.

19 Jul 2013

American Crystallographic Association analysis may help researchers design vaccine against HIV/AIDS

Designing an effective HIV/AIDS vaccine is something of a paradox: a good vaccine would be safe and look enough like HIV to kick-start the immune system into neutralizing the virus - but the problem is that this is exactly what the human immune system has trouble doing even when it's exposed to the real thing.

19 Jul 2013

NCI awards $1.5M grant to LSUHSC researcher to study role of chronic inflammation in cancer

Yan Cui, PhD, Associate Professor of Microbiology, Immunology, & Parasitology at LSU Health Sciences Center New Orleans and the LSUHSC Stanley S. Scott Cancer Center, has been awarded a $1.5 million grant over five years by the National Cancer Institute to study the role of chronic inflammation in the development and progression of cancer.

19 Jul 2013

Anacor presents Phase 3 safety and efficacy results of Tavaborole for treatment of onychomycosis

Anacor Pharmaceuticals (NASDAQ:ANAC) announced today that its abstract "Pivotal Phase 3 Safety and Efficacy Results of Tavaborole (Formerly AN2690), a Novel Boron-Based Molecule for the Topical Treatment of Toenail Onychomycosis" was accepted for oral presentation at the 2013 APMA Annual Scientific Meeting (The National) to be held in Las Vegas, Nevada.

19 Jul 2013

Ensemble Therapeutics announces initiation of drug discovery collaboration with Alexion subsidiary

Ensemble Therapeutics, a biotechnology company developing Ensemblins, a novel class of small molecule therapeutics with the potential to modulate targets typically addressed by biologics, today announced the initiation of a drug discovery collaboration with a subsidiary of Alexion Pharmaceuticals, Inc., the global biopharmaceutical company focused on developing and commercializing life-transforming therapies for patients with life-threatening, ultra-rare disorders.

18 Jul 2013

Kolltan signs research agreement with CHOP for novel therapeutic approaches for neuroblastoma

Kolltan Pharmaceuticals, Inc., a privately held biopharmaceutical company, today announced a license and research agreement with The Children's Hospital of Philadelphia to commence a collaboration with Yaël Mossé, M.D, an internationally recognized clinician and scientist for her work studying the causes and novel therapeutic approaches for the treatment of children diagnosed with neuroblastoma.

18 Jul 2013

Plague detection through anti-carbohydrate antibodies could lead to rapid diagnosis

Even today, the lives of humans and animals are claimed by plague. A new antibody-based detection method can be used to reliably and sensitively identify plague in patient serum and other biological samples.

18 Jul 2013

TSRI scientists study 3-D structure of glucagon receptor for treatment of diabetes

The study is reported on July 17, 2013, in an advance online edition of the journal Nature, alongside a British laboratory's structural study of another member of the same class of receptors-known as "class B" G protein-coupled receptors (GPCRs).

18 Jul 2013

Novel way to fine-tune activity of cells' protein-disposing machinery with cancer-fighting effects

Molecular biologists in the School of Medicine at The University of Texas Health Science Center San Antonio have found a novel way to fine-tune the activity of cells' protein-disposing machinery, with potentially cancer-fighting effects.

18 Jul 2013

Chemical compound from ocean microbe offers potential treatments for anthrax

A team led by William Fenical at Scripps Institution of Oceanography at UC San Diego has discovered a new chemical compound from an ocean microbe in a preliminary research finding that could one day set the stage for new treatments for anthrax and other ailments such as methicillin-resistant Staphylococcus aureus (MRSA).

18 Jul 2013

TAp73 protein frequently overexpressed in wide range of human tumors

They say you can pick your friends, but not your family. The same may hold true for related proteins. The protein TAp73 is a relative of the well-known, tumor-suppressor protein p53. It shares extensive common gene sequences with p53 and, as suggested by some previous studies, it may function similar to p53 to prevent tumor formation.

17 Jul 2013

Magnets could be used for directing stem cells, may help treat heart and vascular diseases

Magnets could be a tool for directing stem cells' healing powers to treat conditions such as heart disease or vascular disease.

17 Jul 2013

Pair of studies sheds light on cancer cell signaling

A pair of studies by a team of University of Notre Dame researchers led by Crislyn D'Souza-Schorey, professor of biological sciences, sheds light on a biological process which is activated across a vast range of malignancies.

16 Jul 2013

Law of physics can be demonstrated by collection of individual protein molecules

Experiments by biochemists at the University of California, Davis show for the first time that a law of physics, the ergodic theorem, can be demonstrated by a collection of individual protein molecules -- specifically, a protein that unwinds DNA. The work will be published online by the journal Nature on July 14.

16 Jul 2013

White blood cells and the spread of cancer: an interview with Drs. Lorenzo Ferri and Jonathan Cools-Lartigue, McGill University

As surgeons who take care of cancer patients, we have observed a troubling association between patients who suffer from infections after surgery and the rapid spread of their cancer. We have reported this in lung cancer patients, and others have made these observations in a variety of different cancers. However, the mechanisms responsible for this association are still poorly understood.

16 Jul 2013

Scientists uncover mechanism that controls cell death processes

Scientists have uncovered the mechanism that controls whether cells that are able to suppress immune responses live or die.

15 Jul 2013

Urocortin molecule protects cells from osteoarthritis, say researchers

UK scientists have found a naturally occurring molecule in the body which may have important consequences for treating osteoarthritis. Researchers from The University of Manchester and the University of Westminster have found that the molecule, known as Urocortin, protects cells in the joints from being destroyed.

From The University of Manchester 12 Jul 2013

Molecule News and Research

CLAMP: A newly discovered protein that regulates genes

Structural properties have changed across bacterial families without putting limits on antibiotic resistance

Researchers visualize live cell-to-cell communication pathways in bacteria

Scientists take important step toward pharmacologic development of treatment for fatal brain disorders

American Crystallographic Association analysis may help researchers design vaccine against HIV/AIDS

NCI awards $1.5M grant to LSUHSC researcher to study role of chronic inflammation in cancer

Anacor presents Phase 3 safety and efficacy results of Tavaborole for treatment of onychomycosis

Ensemble Therapeutics announces initiation of drug discovery collaboration with Alexion subsidiary

Kolltan signs research agreement with CHOP for novel therapeutic approaches for neuroblastoma

Plague detection through anti-carbohydrate antibodies could lead to rapid diagnosis

TSRI scientists study 3-D structure of glucagon receptor for treatment of diabetes

Novel way to fine-tune activity of cells' protein-disposing machinery with cancer-fighting effects

Chemical compound from ocean microbe offers potential treatments for anthrax

TAp73 protein frequently overexpressed in wide range of human tumors

Magnets could be used for directing stem cells, may help treat heart and vascular diseases

Pair of studies sheds light on cancer cell signaling

Law of physics can be demonstrated by collection of individual protein molecules

White blood cells and the spread of cancer: an interview with Drs. Lorenzo Ferri and Jonathan Cools-Lartigue, McGill University

Scientists uncover mechanism that controls cell death processes

Urocortin molecule protects cells from osteoarthritis, say researchers

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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