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Arginase might play a role in development of cardiovascular disease in type II diabetics

In a new study published in the scientific journal Circulation, scientists at Karolinska Institutet and Karolinska University Hospital in Sweden show that an enzyme called arginase might have a key part to play in the development of cardiovascular disease in patients who already have type II diabetes.

27 Nov 2012

Experimental flu vaccine technique could reduce time needed to develop new shots for humans

"An experimental vaccine based on a molecule related to DNA protects animals against influenza and may one day offer an ultra-rapid way to develop new shots for humans, German scientists reported on Sunday," Reuters reports.

27 Nov 2012

CLCA1 molecule plays a special role in the mucus pathway

Respiratory conditions that restrict breathing such as asthma and chronic obstructive pulmonary disease (COPD) are common killers worldwide. But no effective treatments exist to address the major cause of death in these conditions - excess mucus production.

26 Nov 2012

Alnylam advances Tuschl II patent estate through the USPTO

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that the United States Patent and Trademark Office has issued Notices of Allowance for three patent applications from the company's exclusively held Tuschl II patent estate.

26 Nov 2012

New therapeutic approach for preventing Alzheimer's disease

Pathological changes typical of Alzheimer's disease were significantly reduced in mice by blockade of an immune system transmitter. A research team from Charité - Universitätsmedizin Berlin and the University of Zurich has just published a new therapeutic approach in fighting Alzheimer's disease in the current issue of Nature Medicine. This approach promises potential in prevention, as well as in cases where the disease has already set in.

26 Nov 2012

Turning off particular cytokines reduces Alzheimer's typical amyloid-- deposits in mice

Alzheimer's disease is one of the most common causes of dementia. In Germany and Switzerland alone, around 1.5 million people are affected, and forecasts predict a doubling of the number of patients worldwide within the next 20 years. The accumulation of particular abnormal proteins, including amyloid-- (Aβ) among others, in patients' brains plays a central role in this disease.

26 Nov 2012

Researchers characterize novel lysosomal PQ protein linked to cystinosis

Researchers at the Université Paris Descartes/CNRS and the Université libre de Bruxelles have made a major breakthrough in the study of cystinosis, a genetic disease that can lead to serious disorders, notably fatal kidney failure.

23 Nov 2012

Methylome modifications offer new measure of a person's biological age

Women live longer than men. Individuals can appear or feel years younger - or older - than their chronological age. Diseases can affect our aging process. When it comes to biology, our clocks clearly tick differently.

22 Nov 2012

Obesity and oxidative stress: an interview with Dr Elizabeth New

Even though oxygen is essential for us to live, it can react with other compounds in the body to produce molecules called free radicals, which are highly reactive and damaging.

22 Nov 2012

Scientists discover telomerase as cause of chronic inflammation in human cancers

A*STAR scientists have identified the enzyme, telomerase, as a cause of chronic inflammation in human cancers. Chronic inflammation is now recognized as a key underlying cause for the development of many human cancers, autoimmune disorders, neurodegenerative diseases, and metabolic diseases such as diabetes.

22 Nov 2012

UNSW-developed nanoparticle could improve effectiveness of chemotherapy for neuroblastoma

In a world-first, researchers from the Australian Centre for Nanomedicine at the University of New South Wales (UNSW) in Sydney have developed a nanoparticle that could improve the effectiveness of chemotherapy for neuroblastoma by a factor of five.

21 Nov 2012

Discovery of DKK1-WNT pathway reveals new drug targets for Alzheimer's

The discovery of the molecular pathway that drives the changes seen in the brains of Alzheimer's patients is reported today, revealing new targets for drug discovery that could be exploited to combat the disease. The study gives the most detailed understanding yet of the complex processes leading to Alzheimer's.

21 Nov 2012

BRIGHTs bind to biomarkers of disease and light up to reveal their location

Called BRIGHTs, the tiny probes described in the online issue of Advanced Materials on Nov. 15, bind to biomarkers of disease and, when swept by an infrared laser, light up to reveal their location.

21 Nov 2012

Small non-coding RNA715 plays an important role in regulating myelin formation in the CNS

Scientists at the Mainz University Medical Center have discovered another molecule that plays an important role in regulating myelin formation in the central nervous system.

21 Nov 2012

New polymer-based system to fight infection, filter water and heal wounds

Working in the lab for the last few years, three generations of University of Akron polymer scientists say their mutual and passionate curiosity about science has led to their discovery of a first-of-its-kind, easily adaptable biocompatible polymer structure able to fight infection, filter water and perform a host of other functions.

20 Nov 2012

Texas Biomed applies patent for new genetically-engineered vaccine strategy to prevent HIV

The Texas Biomedical Research Institute in San Antonio has applied for a patent for a genetically-engineered vaccine strategy to prevent HIV infection that targets the outer layers of body structures that are the first sites of contact with the virus.

20 Nov 2012

Researchers discover new cause of hydrocephalus

Researchers at the University of Iowa have discovered a new cause of hydrocephalus, a devastating neurological disorder that affects between one and three of every 1,000 babies born. Working in mice, the researchers identified a cell signaling defect, which disrupts immature brain cells involved in normal brain development.

20 Nov 2012

Fibulin-3 effective biomarker for pleural mesothelioma

Research suggests that levels of fibulin-3 in plasma and effusions may aid in determining the diagnosis and prognosis of pleural mesothelioma.

16 Nov 2012

Tug of war between Hsp70 and 90 determines how much the body makes of superoxide

Two proteins are in a tug of war that determines how much the body makes of superoxide, a highly reactive and potentially destructive product of oxygen that's dramatically elevated in cardiovascular disease, researchers report.

16 Nov 2012

New insights into how MSCs ‘traffic’ from the circulation into tissues

Mesenchymal stem cells (MSCs), are a newly emerging cellular therapy being tested in approximately 250 clinical trials worldwide to help repair damaged tissues, such as injured heart muscle following a heart attack. The problem is that when culture-expanded MSCs are injected into the circulation, they have trouble gaining access to the inflamed tissues-exactly where their help is needed.

16 Nov 2012

Molecule News and Research

Arginase might play a role in development of cardiovascular disease in type II diabetics

Experimental flu vaccine technique could reduce time needed to develop new shots for humans

CLCA1 molecule plays a special role in the mucus pathway

Alnylam advances Tuschl II patent estate through the USPTO

New therapeutic approach for preventing Alzheimer's disease

Turning off particular cytokines reduces Alzheimer's typical amyloid-- deposits in mice

Researchers characterize novel lysosomal PQ protein linked to cystinosis

Methylome modifications offer new measure of a person's biological age

Obesity and oxidative stress: an interview with Dr Elizabeth New

Scientists discover telomerase as cause of chronic inflammation in human cancers

UNSW-developed nanoparticle could improve effectiveness of chemotherapy for neuroblastoma

Discovery of DKK1-WNT pathway reveals new drug targets for Alzheimer's

BRIGHTs bind to biomarkers of disease and light up to reveal their location

Small non-coding RNA715 plays an important role in regulating myelin formation in the CNS

New polymer-based system to fight infection, filter water and heal wounds

Texas Biomed applies patent for new genetically-engineered vaccine strategy to prevent HIV

Researchers discover new cause of hydrocephalus

Fibulin-3 effective biomarker for pleural mesothelioma

Tug of war between Hsp70 and 90 determines how much the body makes of superoxide

New insights into how MSCs ‘traffic’ from the circulation into tissues

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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