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Anacor, Medicis collaborate to discover and develop boron-based treatment for acne

Anacor Pharmaceuticals, Inc. and Medicis Pharmaceutical Corporation today announced that the two companies have entered into a research and development agreement to discover and develop boron-based small molecule compounds directed against a target for the potential treatment of acne.

11 Feb 2011

Intellikine, PKD Foundation to investigate novel therapies for patients with PKD

Intellikine, a leader in the development of small molecule drugs targeting the PI3K/mTOR pathway, and the PKD Foundation today announced a collaboration to investigate novel, orally-available small molecule kinase inhibitors of the TORC1 and TORC2 complexes as a potential treatment for patients with polycystic kidney disease.

11 Feb 2011

Patients with high blood pressure have benign endocrine tumours in adrenal gland: Research

High blood pressure may in some cases be caused by benign hormone-producing tumours of the adrenal cortex. A joint Swedish-American research effort has now uncovered a genetic cause behind the occurrence of such tumours. The findings were published today in the journal Science.

11 Feb 2011

Study: New curcumin-hybrid compound may help protect, regenerate brain cells after stroke

Whether or not you're fond of Indian, Southeast Asian and Middle Eastern food, stroke researchers at Cedars-Sinai Medical Center think you may become a fan of one of their key spices.

10 Feb 2011

PolyMedix commences PMX-60056 Phase 2 clinical trial in patients undergoing PCI

PolyMedix, Inc., an emerging biotechnology company focused on developing new therapeutic drugs to treat infectious diseases and acute cardiovascular disorders, has initiated a Phase 2 clinical trial, following conclusion of a review by the United States Food and Drug Administration (FDA) of a protocol submitted by PolyMedix, to assess the safety and efficacy of its heptagonist, PMX-60056, in reversing heparin in patients undergoing Percutaneous Coronary Intervention (PCI) procedures.

9 Feb 2011

CeNeRx announces FDA approval of CXB909 IND for neuroprotection and neurodegenerative disorders

CeNeRx BioPharma, Inc., a clinical-stage company developing and commercializing innovative treatments for diseases of the central nervous system (CNS), today announced FDA approval of its IND and reported the first clinical results in humans for CXB909, a novel agent that has demonstrated utility in preclinical models of neuroprotection and neurodegenerative disorders.

9 Feb 2011

Single molecule imaging movies of living cell membranes clarify enigma surrounding receptor molecule behaviors

Unprecedented single molecule imaging movies of living cell membranes, taken by a research team based at Kyoto University and the University of New Mexico, have clarified a decades-old enigma surrounding receptor molecule behaviors. The results, appearing in the latest issue of the Journal of Cell Biology, promise to open the door to new possibilities for drug development.

9 Feb 2011

Rapid detection of transiently folded single-molecule structures from 'intrinsically disordered proteins'

A team of scientists from The Scripps Research Institute and the University of California, San Diego (UCSD) have developed a novel technique to observe previously unknown details of how folded structures are formed from an intrinsically disordered protein. The insights could help scientists to better understand the mechanism of plaque formation in neurodegenerative disorders such as Parkinson's and Alzheimer's diseases.

9 Feb 2011

Circassia acquires global rights to novel topical therapeutic for psoriasis and atopic dermatitis

Circassia Ltd, a specialty biopharmaceutical company focused on allergy, today announced that it has acquired the worldwide development and commercialization rights to the novel topical therapeutic for psoriasis and atopic dermatitis, PAP-1. Circassia acquired the rights to the proprietary molecule from Airmid Inc, for an undisclosed upfront sum plus milestone payments and royalties on future product sales.

9 Feb 2011

Scientists develop novel technique to detect disordered protein folding

A team of scientists from The Scripps Research Institute and the University of California, San Diego have developed a novel technique to observe previously unknown details of how folded structures are formed from an intrinsically disordered protein.

9 Feb 2011

Scientists use fruit flies to study how prenatal alcohol exposure causes FAS

Drinking excess alcohol during pregnancy can cause fetal alcohol syndrome (FAS) due to the damaging effects of alcohol on a developing baby's brain. Despite its harmful effects, pregnant mothers continue to drink alcohol - up to 3 in every 1000 babies are born with FAS, which causes intellectual disabilities, behavioural problems, growth defects and abnormal facial features.

8 Feb 2011

Single molecule FRET techniques combined with wavelet transforms give new view of AMPA receptor

A digital signal processing technique long used by statisticians to analyze data is helping Houston scientists understand the roots of memory and learning, Alzheimer's and Parkinson's diseases and stroke.

8 Feb 2011

Researchers identify immune cell population that acts as body's border patrol with the outside world

So-called barrier sites -- the skin, gut, lung - limit the inner body's exposure to allergens, pollutants, viruses, bacteria, and parasites. Understanding how the immune system works in these external surfaces has implications for understanding such inflammatory diseases as asthma, psoriasis, IBD, and food allergies, all of which occur at the body's barriers.

8 Feb 2011

Ansaris receives milestone payment for identification of kinase-related compound for cancer, autoimmune diseases

Ansaris announced today that it has received a milestone payment for the successful identification of a kinase-related compound under its drug discovery collaboration with Ono Pharmaceutical Co., Ltd. Ono will initiate the preclinical study of the identified compound. This collaboration between Ansaris and Ono was established to focus on the discovery of kinase-related compounds for the treatment of cancer, inflammatory and autoimmune diseases.

8 Feb 2011

Study identifies genetic variation linked with increased risk of major depression

Numerous studies have shown that the brain molecule neuropeptide Y (NPY) helps to restore calm after stressful events. A team of University of Michigan-led researchers has now found that people whose genes predispose them to produce lower levels of NPY are more responsive to negative stimuli in key brain circuits related to emotion - and are therefore less resilient in the face of stress and may be at higher risk for developing a major depressive disorder.

8 Feb 2011

Transition reports second quarter 2011 net income of $24.28M vs. $6.05M net loss for second quarter 2010

Transition Therapeutics Inc., a product-focused biopharmaceutical company developing therapeutics for disease indications with large markets, today announced its financial results for the quarter ended December 31, 2010.

8 Feb 2011

Researchers identify CHK1 protein may serve as treatment target for neuroblastoma

After analyzing hundreds of proteins produced by the DNA of tumor cells, researchers have identified one protein that may be central to a new treatment for the often-fatal childhood cancer neuroblastoma. Oncologists hope to translate the finding into pediatric clinical trials of a drug that blocks the protein's activity.

7 Feb 2011

Super spinach really boosts power: Study

Scientists have found out the basis of what we already knew – spinach is good for us. They have found that it is the nitrates in spinach that are abundant in all green leafy vegetables that boosts the powerhouses in cells which provide energy. In fact a single helping of spinach is enough to increase the efficiency of mitochondria. These are small bean-shaped bodies which fuel cell activity and growth. This explains how Popeye the Sailor man – a famous cartoon character, who dates back to the 1930s, gets his power from a can of spinach.

6 Feb 2011

Anti-cancer drug tied to golden missiles

Researchers at Case Western Reserve University have developed a little bomb that promises a big bang for cancer patients.

5 Feb 2011

Endocyte prices initial public offering

Endocyte, Inc., a biopharmaceutical company developing targeted small molecule drug conjugates, announced today the pricing of its initial public offering of 12,500,000 shares of its common stock.

5 Feb 2011

Molecule News and Research

Anacor, Medicis collaborate to discover and develop boron-based treatment for acne

Intellikine, PKD Foundation to investigate novel therapies for patients with PKD

Patients with high blood pressure have benign endocrine tumours in adrenal gland: Research

Study: New curcumin-hybrid compound may help protect, regenerate brain cells after stroke

PolyMedix commences PMX-60056 Phase 2 clinical trial in patients undergoing PCI

CeNeRx announces FDA approval of CXB909 IND for neuroprotection and neurodegenerative disorders

Single molecule imaging movies of living cell membranes clarify enigma surrounding receptor molecule behaviors

Rapid detection of transiently folded single-molecule structures from 'intrinsically disordered proteins'

Circassia acquires global rights to novel topical therapeutic for psoriasis and atopic dermatitis

Scientists develop novel technique to detect disordered protein folding

Scientists use fruit flies to study how prenatal alcohol exposure causes FAS

Single molecule FRET techniques combined with wavelet transforms give new view of AMPA receptor

Researchers identify immune cell population that acts as body's border patrol with the outside world

Ansaris receives milestone payment for identification of kinase-related compound for cancer, autoimmune diseases

Study identifies genetic variation linked with increased risk of major depression

Transition reports second quarter 2011 net income of $24.28M vs. $6.05M net loss for second quarter 2010

Researchers identify CHK1 protein may serve as treatment target for neuroblastoma

Super spinach really boosts power: Study

Anti-cancer drug tied to golden missiles

Endocyte prices initial public offering

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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