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BioMarin completes BMN 195 Phase 1 clinical trial for Duchenne muscular dystrophy

BioMarin Pharmaceutical Inc. announced today that it has completed the Phase 1 clinical study of BMN 195, a small molecule utrophin up-regulator, for the treatment of Duchenne muscular dystrophy (DMD). The Phase 1 clinical trial was a single-center, double-blind, placebo-controlled, single-dose escalation study followed by a multiple-dose escalation study in healthy volunteers.

3 Aug 2010

Osteologix grants Servier Research Group exclusive license to develop, commercialize NB S101

Osteologix, Inc. through its wholly owned Irish subsidiary Osteologix Limited and the Servier Research Group, the leading French independent pharmaceutical company, today announced that Osteologix has granted Servier an exclusive royalty bearing license to develop and commercialize NB S101 (strontium malonate) to treat post menopausal osteoporosis, other bone and joint disorders and dental indications worldwide, except in the U.S. NB S101 is an innovative molecule acting on both bone formation and bone resorption.

2 Aug 2010

microRNA protects red blood cells from oxidant stress: Study

Pediatric researchers have discovered a new biological pathway in which small segments of RNA, called microRNA, help protect red blood cells from injury caused by chemicals called free radicals. The microRNA seems to have only a modest role when red blood cells experience normal conditions, but steps into action when the cells are threatened by oxidant stress.

2 Aug 2010

Active ingredients continue to attract new, loyal investors

Active ingredients ranging from weight-loss herbals to cancer-killing cytotoxics attract billions in venture investment dollars every year. But technologies designed to selectively deliver active ingredients to targeted locations are beginning to gain momentum, as their application in drugs, medical devices, food, personal care, and agricultural chemicals rapidly grows and corporate venture investors take notice, according to a new report from Lux Research.

31 Jul 2010

Research establishes bases of possible future pharmaceutical drugs to combat AIDS virus

The doors are closing on the AIDS virus. The scientific community continues to strive to find the formula that will halt the advance of one of the viruses that has sparked most scientific interest over recent years. A study by the Consejo Superior de Investigaciones Cient-ficas (CSIC) and led by Mr F-lix Go-i, director of the Biophysics Unit at the CSIC-University of the Basque Country Mixed Centre, has developed a method of attack against the AIDS virus The method involves creating a prevention system, i.e. an 'armour' in the cells that are likely to be infected and thus impede, de facto, the virus from accessing them and starting to act on their immunological system.

31 Jul 2010

Self assembly approaches to improve DNA sequencing

In an innovation critical to improved DNA sequencing, a markedly slower transmission of DNA through nanopores has been achieved by a team led by Sandia National Laboratories researchers.Solid-state nanopores sculpted from silicon dioxide are generally straight, tiny tunnels more than a thousand times smaller than the diameter of a human hair. They are used as sensors to detect and characterize DNA, RNA and proteins. But these materials shoot through such holes so rapidly that sequencing the DNA passing through them, for example, is a problem.

31 Jul 2010

Scientists identify enzyme to prevent beta-amyloids formation in Alzheimer patients

The brains of Alzheimer patients have high accumulations of the material beta-amyloid, which appear in the form of plaques. The precursors of these plaques are believed to be the underlying cause of the nerve cell loss that leads to the disruptions in memory that characterize Alzheimer's disease. The main aim of many Alzheimer therapies is therefore to inhibit the formation of beta-amyloid. Since beta-amyloid is cleaved from the so-called amyloid precursor protein (APP), scientists have focused on stopping the two enzymes that attack the precursor protein. These act like molecular scissors and cut out the beta-amyloid fragment. Blocking these scissors precludes the formation of beta-amyloid.

31 Jul 2010

Chemical compound provides new angle for developing drugs to treat seizures: Study

A chemical compound that boosts the action of a molecule normally produced in the brain may provide the starting point for a new line of therapies for the treatment of epileptic seizures, according to a new study by scientists at The Scripps Research Institute.

30 Jul 2010

Buckyball Discovery Conference to be held Oct. 10-13 at Rice University

The biggest names in nanotechnology are preparing to gather this fall at Rice University, and everyone is welcome to join them.

30 Jul 2010

PPD expands cGMP laboratory testing services into Wayne

PPD, Inc. today announced it has expanded its cGMP laboratory testing services into Wayne, Pa., to meet growing client demand for these services from pharmaceutical and biotechnology companies located in the northeastern United States.

30 Jul 2010

Helicos' single-molecule sequencing technology for detection, quantification of novel small RNA

Helicos BioSciences Corporation today announced a publication demonstrating the detection and quantification of novel small RNA molecules using Helicos' single-molecule sequencing technology. These data confirm a long-held, unproven hypothesis that mammalian cells are capable of synthesizing RNA by copying RNA molecules directly.

30 Jul 2010

Bio-Path commences dosing in Liposomal Grb-2 Phase I cancer study

Bio-Path Holdings, Inc.,, a biotechnology company with drug development operations in Houston, Texas, announced today that the first patient has been dosed in a Phase I study of its cancer drug candidate, Liposomal Grb-2 (L-Grb-2 or BP-100-1.01), in patients with Acute Myeloid Leukemia (AML), Chronic Myelogenous Leukemia (CML), Acute Lymphoblastic Leukemia (ALL) or Myelodysplastic Syndrome (MDS).

30 Jul 2010

Researchers find new pathway that leads to brain cell death in neurodegenerative disorders

Although their genetic underpinnings differ, Alzheimer's disease, Parkinson's disease and Huntington's disease are all characterized by the untimely death of brain cells. What triggers cell death in the brain? According to a new study published by researchers at Sanford-Burnham Medical Research Institute in the July 30 issue of Molecular Cell, the answer in some cases is the untimely transfer of a gaseous molecule (known as nitric oxide, or NO) from one protein to another.

30 Jul 2010

New findings on snake venom toxin hold promise for developing heart disease, cancer therapies

Researchers seeking to learn more about stroke by studying how the body responds to toxins in snake venom are this week releasing new findings that they hope will aid in the development of therapies for heart disease and, surprisingly, cancer. The Japanese team is reporting in a Journal of Biological Chemistry "Paper of the Week" that they are optimistic that inhibiting a protein found on the surface of blood cells known as platelets may combat both irregular blood clotting and the spread of certain cancers throughout the body.

30 Jul 2010

Researchers develop new fluorescent biosensor for drug development

Researchers at Carnegie Mellon University have developed a new fluorescent biosensor that could aid in the development of an important class of drugs that target a crucial class of proteins called G protein-coupled receptors (GPCRs).

30 Jul 2010

Researchers discover enzyme crucial for DNA repair

Researchers have discovered an enzyme crucial to a type of DNA repair that also causes resistance to a class of cancer drugs most commonly used against ovarian cancer.Scientists from The University of Texas MD Anderson Cancer Center and the Life Sciences Institute of Zhejiang University in China report the discovery of the enzyme and its role in repairing DNA damage called cross-linking in the Science Express advance online publication of Science.

30 Jul 2010

Tel Aviv University discovers molecular power behind memory

Neuroscientists have long wondered how individual connections between brain cells remain diverse and "fit" enough for storing new memories. Reported in the prestigious science journal Neuron, a new study led by Dr. Inna Slutsky of the Sackler School of Medicine at Tel Aviv University describes what makes some memories stick.

30 Jul 2010

Geron second-quarter net loss decreases to $17.0 million

Geron Corporation today reported financial results for the three and six months ended June 30, 2010.

30 Jul 2010

Researchers find how angiotensin influences immune system

Researchers in Heidelberg and Stanford have discovered a new signalling pathway of brain cells that explains how widely used antihypertensive drugs could keep inflammation in multiple sclerosis in check. The peptide angiotensin not only raises blood pressure but also activates the immunological messenger substance TGF beta on a previously unknown communication pathway in the brain.

29 Jul 2010

Genetic signals determine neurotransmitter use for communication

Cascades of genetic signals determine which neurotransmitter a brain cell will ultimately use to communicate with other cells. Now a pair of reports from biologists at the University of California, San Diego, have shown for the first time that electrical activity in these developing neurons can alter their chemical fate-and change an animal's behavior-by tweaking this genetic program.

29 Jul 2010

Molecule News and Research

BioMarin completes BMN 195 Phase 1 clinical trial for Duchenne muscular dystrophy

Osteologix grants Servier Research Group exclusive license to develop, commercialize NB S101

microRNA protects red blood cells from oxidant stress: Study

Active ingredients continue to attract new, loyal investors

Research establishes bases of possible future pharmaceutical drugs to combat AIDS virus

Self assembly approaches to improve DNA sequencing

Scientists identify enzyme to prevent beta-amyloids formation in Alzheimer patients

Chemical compound provides new angle for developing drugs to treat seizures: Study

Buckyball Discovery Conference to be held Oct. 10-13 at Rice University

PPD expands cGMP laboratory testing services into Wayne

Helicos' single-molecule sequencing technology for detection, quantification of novel small RNA

Bio-Path commences dosing in Liposomal Grb-2 Phase I cancer study

Researchers find new pathway that leads to brain cell death in neurodegenerative disorders

New findings on snake venom toxin hold promise for developing heart disease, cancer therapies

Researchers develop new fluorescent biosensor for drug development

Researchers discover enzyme crucial for DNA repair

Tel Aviv University discovers molecular power behind memory

Geron second-quarter net loss decreases to $17.0 million

Researchers find how angiotensin influences immune system

Genetic signals determine neurotransmitter use for communication

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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