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Magnetic nano tweezers show how cancer drug works

The annoying bulges of an over-wound telephone cord that shorten its reach and limit a caller's motion help to explain why drugs called camptothecins are so effective in killing cancer cells, according to investigators at St. Jude Children's Research Hospital and Delft University of Technology.

10 Jul 2007

University Jaume I patents fluorescent sensor

The University Jaume I (UJI) has patented a new fluorescent chemical sensor that is capable of detecting citric acid at low concentrations more rapidly and cheaply than the current optical sensors.

9 Jul 2007

Scientists discover protein instrumental to brain development and repair

Scientists at Children's National Medical Center have demonstrated conclusively that a specific protein and its signaling activity are instrumental in myelination and remyelination, processes essential to the creation and repair of the brain's white matter.

9 Jul 2007

New working principle in cancer treatment

Due to defects in chromosomal distribution, a majority of tumor cells would not be able to survive were it not for a trick that cancer cells have developed to avoid this chaos in the genetic material.

5 Jul 2007

Central command system for pulmonary hypertension discovered

Researchers at the University of Alberta have identified a "central command system" for pulmonary hypertension, a disease that currently has no cure and kills thousands each year.

4 Jul 2007

Biomira files NDA for novel inhibitor of hypoxia-inducible factor-1 alpha

Biomira Inc. has announced that it has submitted an investigational new drug (IND) application to the U.S. Food and Drug Administration for PX-478. PX-478 has been shown in preclinical studies to inhibit hypoxia-inducible factor (HIF)-1 alpha, a protein that controls the transcription of a number of genes whose products are important for tumor growth and survival.

4 Jul 2007

Food allergy sufferers offered hope of new treatment

In a joint UK and Italian study scientists say they have discovered a possible treatment for people who suffer from food allergies.

3 Jul 2007

RNA molecules can orchestrate gene activity across vast portions of the human genome

Large, seemingly useless pieces of RNA - a molecule originally considered only a lowly messenger for DNA - play an important role in letting cells know where they are in the body and what they are supposed to become, researchers at Stanford University School of Medicine have discovered.

29 Jun 2007

Link between ciliary signaling and cancer

Submarines have periscopes. Insects have antennae. And increasingly, biologists are finding that most normal vertebrate cells have cilia, small hair-like structures that protrude like antennae into the surrounding environment to detect signals that control cell growth.

29 Jun 2007

Scientists create sheets of protein-gold arrays

In groundbreaking research, scientists have demonstrated the ability to strategically attach gold nanoparticles -- particles on the order of billionths of a meter -- to proteins so as to form sheets of protein-gold arrays.

28 Jun 2007

CARS microscopy reveals clues to myelin damage

Researchers have discovered that calcium ions could play a crucial role in multiple sclerosis by activating enzymes that degrade the fatty sheath that insulates nerve fibers.

28 Jun 2007

Amphinase molecule from frog could provide first drug treatment for brain tumours

A synthetic version of a molecule found in the egg cells of the Northern Leopard frog (Rana pipiens) could provide the world with the first drug treatment for brain tumours.

27 Jun 2007

A new system for collaboration in cell communication

Investigators from the Institute of Research in Biomedicine (IRB Barcelona) have identified a new signalling mechanism among cells in the fruit fly, Drosophila melanogaster.

27 Jun 2007

New genetic marker characterizes aggressiveness of cancer cells

Levels of a small non-coding RNA molecule called let-7 appear to define different stages of cancer better than some of the "classical" markers for tumor progression, researchers from the University of Chicago report in the June 25, 2007, early online edition of the Proceedings of the National Academy of Sciences.

26 Jun 2007

New understanding of cancer inhibitor topotecan

Researchers in Delft University of Technology's Kavli Institute of Nanoscience in The Netherlands have cast new light on the workings of the important cancer inhibitor topotecan.

26 Jun 2007

Scoliosis gene found

Physicians have recognized scoliosis, the abnormal curvature of the spine, since the time of Hippocrates, but its causes have remained a mystery -- until now. For the first time, researchers have discovered a gene that underlies the condition, which affects about 3 percent of all children.

26 Jun 2007

Does air pollution have a bigger effect on the immune system of females than males?

Does air pollution have a bigger effect on the immune system of females than males? It did among mice exposed to ozone -- a major component in air pollution that is known to negatively affect lung function -- and then infected with pneumonia, as significantly more females died from the infection than males.

26 Jun 2007

Genes play unexpected role in their own activation

Investigators at St. Jude Children's Research Hospital have discovered how a single molecular "on switch" triggers gene activity that might cause effects ranging from learning and memory capabilities to glucose production in the liver.

23 Jun 2007

Gel capsule for diabetes type 1

There is renewed hope for treatment of diabetes type 1 with gel capsules: Biotechnologists at The Norwegian University of Science and Technology (NTNU) have developed a new type of alginate capsule that could solve the problem of the body's immune system recognizing and attacking alien, implanted insulin cells.

23 Jun 2007