Molecule News and Research

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Disorderly protein brings order to cell division

The secret to the ability of a molecule critical for cell division to throw off the protein yoke that restrains its activity is the yoke itself - a disorderly molecule that seems to have a mind of its own, say investigators at St. Jude

13 Mar 2007

New drug target for herpes viruses

Scientists in the lab of Whitehead Institute Member Hidde Ploegh and the Harvard University lab of Rachelle Gaudet have solved the complex structure of a recently discovered protein that is found in a wide range of herpes viruses. This protein may prove to be a potential drug target.

11 Mar 2007

New drug target for herpes viruses

11 Mar 2007

Researchers show how endocrine cell types are produced in the pancreas

An international research team has identified the process by which pancreatic progenitor cells give rise to different endocrine cell types.

8 Mar 2007

Archemix granted two European patents

Archemix has announced today the issuance of two key, broad patents by the European Patent Office ("EPO"). The patents, EP 0 786 469 and EP 0 668 931, broadly cover methods for the identification and use of aptamers for therapeutic applications.

8 Mar 2007

Improvement of cancer-targeting therapy, using nanocarriers for intractable solid tumors by inhibition of TGF-beta signaling

Administering a small amount of a potent but potentially toxic anticancer agent along with nanoparticles loaded with a second anticancer agent produced a dramatic inhibition of tumor growth in normally intractable cancers. These findings suggest a new approach to treating malignancies such as pancreatic cancer and diffuse gastric cancer.

5 Mar 2007

Targeted nanoparticles image early tumors

A well-established fact in cancer therapy is that early tumor detection improves the odds that a patient will survive the disease. Now, using nanoparticles targeted to the tiny blood vessels that surround even the smallest tumors, researchers at the Siteman Center for Cancer Nanotechnology Excellence (CCNE) have developed a radioactive imaging agent that was able to identify human tumors in rabbits.

5 Mar 2007

Fox Chase Cancer Center and Cancer Research Technology initiate drug discovery collaboration

Cancer Research Technology Inc. (CRT Inc.) and Fox Chase Cancer Center have announce the initiation of an oncology-focused drug discovery collaboration.

1 Mar 2007

Key protein - claudin-1- for hepatitis C virus entry identified

For as many as 200 million people worldwide infected with hepatitis C, a leading cause of chronic liver disease, treatment options are only partially effective. But new research by Rockefeller University scientists points to a potential new target for better drugs: a key protein that resides in human liver cells that hepatitis C requires for entry.

27 Feb 2007

DNA 'cages' to deliver drugs

By combining DNA macromolecules with polymers containing iron, molecular 'cages' can be made: porous structures capable of carrying and delivering drugs or DNA-fragments.

26 Feb 2007

siRNA delivery into human T cells and primary cells with carbon-nanotube transporters

Short pieces of RNA, known as small interfering RNA (siRNA), have the potential to become a new class of anticancer drugs if researchers can solve the problem of how to deliver these fragile molecules to cancer cells.

26 Feb 2007

Research defines the cancer role for protein Gab-2

A protein known for its ability to "bridge" interactions between other cellular proteins may spur metastasis in breast cancer, the disease's deadliest stage, a study from Burnham Institute for Medical Research has found.

22 Feb 2007

microRNAs undergo molecular editing with significant physiological consequences

Tiny molecules called microRNAs, only 19 to 21 nucleotides in length, are able to effectively silence sometimes large sets of genes. They do this by specifically binding to and neutralizing another form of RNA called messenger RNA, responsible for conveying the information from genes to the cellular machinery that uses that information to create proteins, the building blocks of the body.

22 Feb 2007

How DNA is packed

The life cycles of many viruses include a self-assembly stage in which a powerful molecular motor must pack the DNA genome into the virus's preformed shell (the capsid). How it manages this intricate feat has been subject to debate, but we know that the DNA passes into the capsid shell through a channel formed by a structure called the connector. Scientists have speculated that rotation of the connector complex might feed the DNA into the capsid as it turns.

20 Feb 2007

Nanoparticles advance photodynamic therapy to kill tumor cells

Photodynamic therapy (PDT) is a powerful approach for destroying tumors, one that uses light and a light-sensitive chemical to rapidly kill cells.

20 Feb 2007

Nanoparticles rely on 'velcro effect' to target tumor cells

One of the basic tenets of targeted nanoparticle drug delivery is putting multiple targeting molecules on a nanoparticle surface will improve the ability of nanoparticles to stick to their targeted cell and deliver their drug cargos to the appropriate diseased cell.

20 Feb 2007

Cell pathway identified which plays critical role in colon cancer

For the one in 18 men and women who will be diagnosed with cancer of the colon and rectum during their lifetime and over 150,000 people diagnosed on a yearly basis, today's genetic research news offers some optimism.

20 Feb 2007

C-Reactive protein plays a direct role in the onset of hypertension

We have discovered that C-Reactive Protein (CRP) is not merely a marker of the risk of hypertension, it actually induces hypertension.

19 Feb 2007

Legislation introduced that would give FDA authority to approve generic versions of biotechnology drugs

Lawmakers in the House and Senate on Wednesday introduced a bill that would allow FDA to approve generic versions of biotechnology medications, USA Today reports.

19 Feb 2007

The present and future for influenza vaccines

The near inevitability that influenza will explode into a pandemic in the coming few years has kept researchers searching for a way to prevent the worst effects of infection. The ultimate prize is a highly effective vaccine that could be produced and deployed rapidly.

18 Feb 2007