Monoclonal Antibody News and Research

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Monoclonal antibodies (MAbs) are produced from a single B cell clone and can bind to a single type of antigen binding site. MAbs are homogenous antibodies that cannot form lattices with monomeric proteins as they can bind to only a single epitope on the antigen. Developed in the 1970s, MAbs can be produced against any given substance. Thus they can be used to detect and purify any substance of interest. This has made MAbs a powerful tool of molecular biology, biochemistry, and medicine.

Mediterranean diet supercharges skin treatment, clears up atopic dermatitis in teen

Study reports on a 14-year-old boy with atopic dermatitis who experienced complete symptom resolution after combining monoclonal antibody treatment with a Mediterranean diet. Highlighting the role of diet in managing inflammatory skin conditions, the case study suggests the therapeutic potential of integrating dietary changes with medical treatment for improved outcomes.

10 Sep 2023

Study evaluating intranasal anti-CD3 for treatment of Alzheimer’s disease published in the PNAS journal

Tiziana Life Sciences Ltd. (“Tiziana” or the “Company”), a biotechnology company developing breakthrough immunomodulation therapies via novel routes of drug delivery, today announced acceptance of a publication, “Nasal Administration of anti-CD3 monoclonal antibody (mAb) ameliorates disease in a mouse model of Alzheimer’s disease”, in the preeminent journal, Proceedings of the National Academy of Sciences (PNAS), that supports foralumab’s mechanism as a potential treatment for Alzheimer’s disease (AD), a difficult-to-treat neuroinflammatory disease.

9 Sep 2023

TTUHSC El Paso's community engagement efforts helped address COVID-19 disparities

In summer 2020, Edward Michelson, M.D., chair of TTUHSC El Paso's Department of Emergency Medicine, had developed a new daily routine.

8 Sep 2023

MD Anderson and Panacea create Manaolana Oncology to develop novel portfolio of monoclonal antibodies

The University of Texas MD Anderson Cancer Center and Panacea Venture today announced the launch of Manaolana Oncology Inc., a new company created to develop and advance antibody-based therapies against novel cancer antigens.

6 Sep 2023

Study characterizes SARS-CoV-2 subvariants to inform development of next-generation COVID-19 vaccines

Researchers characterized two novel SARS-CoV-2 XBB variants, EG.5.1 and XBB.2.3.

4 Sep 2023

Big Tuna and automated buffer exchange: An interview with Unchained Labs

In this interview, AZoNetwork speaks with Joe Barco, the Senior Director of Workflow Marketing at Unchained Labs, about the benefits of automated buffer exchange with Big Tuna.

From Unchained Labs 4 Sep 2023

Weighted lottery helps ensure equitable allocation of scarce COVID-19 medication

A program designed to ensure fairness and that people living in the most disadvantaged U.S. neighborhoods would be offered a scarce, potentially life-saving medication proved feasible in a large health system.

1 Sep 2023

Researchers unearth secrets of zinc transporter protein

A group of researchers has unearthed the secrets behind a tiny but crucial protein that shuttles zinc ions (Zn2+) within our bodies. The discovery offers a deeper understanding of how our cells maintain optimal health.

31 Aug 2023

Man-made antibody successfully prevents organ rejection after transplantation

A man-made antibody successfully prevented organ rejection when tested in primates that had undergone a kidney transplant, Duke Health researchers report.

30 Aug 2023

UTMB research potentially points to an effective treatment for Lassa fever

New research out of the University of Texas Medical Branch potentially points to an effective treatment for Lassa fever, a dangerous, often fatal disease common to much of West Africa but considered a major threat to global health.

24 Aug 2023

Differences in immune responses to IL-6 inhibition therapy between male and female COVID-19 patients

Researchers investigated whether anti‑interleukin 6 monoclonal antibodies were related to heterogenous treatment effects between male and female COVID-19 patients.

24 Aug 2023

Timing and cost of new vaccines vary by virus and health insurance status

As summer edges toward fall, thoughts turn to, well, vaccines.

24 Aug 2023

New targeted therapy zolbetuximab extends survival for patients with advanced gastric cancer

An international phase 3 clinical trial, done in participation with Weill Cornell Medicine and NewYork-Presbyterian, found that a new targeted treatment called zolbetuximab, given in combination with a standard chemotherapy, extended survival for patients with advanced gastric or gastroesophageal junction cancer that overexpressed a specific biomarker.

23 Aug 2023

Project NextGen awards over $1.4 billion to develop the future of COVID-19 vaccines and therapeutics

Funding includes $1 billion for vaccine clinical trials, $326 million for a new monoclonal antibody, and $100 million to explore novel vaccine and therapeutic technologies.

23 Aug 2023

Potential of COVID-19 convalescent plasma for future monoclonal antibodies against severe SARS-CoV-2 inflammation

Researchers report that convalescent plasma treatment is most effective in treating hospitalized COVID-19 patients.

17 Aug 2023

Only a small percentage of older adults with early Alzheimer's eligible for new treatments

Only a small percentage of older adults who are in the early stages of Alzheimer's disease meet the eligibility criteria to receive new monoclonal antibody treatments, drugs that target amyloid-ß plaques in the brain, an early sign of Alzheimer's disease.

16 Aug 2023

Most infants admitted to ICU for RSV were previously healthy, study finds

Most infants admitted to the intensive care or high acuity unit for respiratory syncytial virus (RSV) infections during fall 2022 were previously healthy and born at term, according to a new study reported in JAMA Network Open.

16 Aug 2023

New Alzheimer’s drug raises hopes — along with questions

The FDA has approved Leqembi, the first disease-modifying treatment for early-stage Alzheimer's and a precursor condition, mild cognitive impairment.

11 Aug 2023

Immunotherapy after stem cell transplantation effectively combats certain childhood nerve tumors

Scientists at St. Anna Children's Cancer Research Institute and the Eberhard Karls University of Tübingen have shown that immunotherapy after stem cell transplantation effectively combats certain nerve tumors in children.

9 Aug 2023

RSV vaccine recommendation rates increase when people are informed about FDA approval process

A new study finds that people are more likely to recommend that a pregnant family member or friend get vaccinated to protect the infant from RSV illness if they are shown a chart outlining the rigorous process a vaccine undergoes to be approved by the Food and Drug Administration (FDA).

9 Aug 2023

Monoclonal Antibody News and Research

Further Reading

Mediterranean diet supercharges skin treatment, clears up atopic dermatitis in teen

Study evaluating intranasal anti-CD3 for treatment of Alzheimer’s disease published in the PNAS journal

TTUHSC El Paso's community engagement efforts helped address COVID-19 disparities

MD Anderson and Panacea create Manaolana Oncology to develop novel portfolio of monoclonal antibodies

Study characterizes SARS-CoV-2 subvariants to inform development of next-generation COVID-19 vaccines

Big Tuna and automated buffer exchange: An interview with Unchained Labs

Weighted lottery helps ensure equitable allocation of scarce COVID-19 medication

Researchers unearth secrets of zinc transporter protein

Man-made antibody successfully prevents organ rejection after transplantation

UTMB research potentially points to an effective treatment for Lassa fever

Differences in immune responses to IL-6 inhibition therapy between male and female COVID-19 patients

Timing and cost of new vaccines vary by virus and health insurance status

New targeted therapy zolbetuximab extends survival for patients with advanced gastric cancer

Project NextGen awards over $1.4 billion to develop the future of COVID-19 vaccines and therapeutics

Potential of COVID-19 convalescent plasma for future monoclonal antibodies against severe SARS-CoV-2 inflammation

Only a small percentage of older adults with early Alzheimer's eligible for new treatments

Most infants admitted to ICU for RSV were previously healthy, study finds

New Alzheimer’s drug raises hopes — along with questions

Immunotherapy after stem cell transplantation effectively combats certain childhood nerve tumors

RSV vaccine recommendation rates increase when people are informed about FDA approval process

Immunology eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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