Monocyte News and Research

RSS

Study reveals new therapeutic options for multiple sclerosis

Multiple sclerosis is known as "the disease with a thousand faces" because symptoms and progression can vary dramatically from patient to patient.

20 Apr 2020

Potential new therapies for multiple sclerosis

In every MS patient cells of their body's own immune system migrate to the brain, where they destroy the myelin sheath.

20 Apr 2020

Gimsilumab trial starts in first US patient with ARDS and COVID-19

The first American patient with COVID-19 and acute respiratory distress syndrome (ARDS) has been put on the drug gimsilumab at Temple University Hospital, as part of the BREATHE clinical trial. The trial, sponsored by Roivant Sciences, will evaluate the effectiveness of intravenous gimsilumab in preventing death in patients with COVID-19 and ARDS.

16 Apr 2020

Macrophages migrate from the blood to attack brain tissue shortly after stroke

Macrophages are part of the innate immune system and essential for brain development and function. Using a novel method, scientists from Jena University Hospital, the University of Bonn and the Memorial Sloan Kettering Cancer Center in New York (USA) succeeded in visualizing macrophages that were formed in the bone marrow.

11 Feb 2020

UAB study suggests potential treatment target for IPF

Long-held dogma says lung fibrosis in diseases like idiopathic pulmonary fibrosis, or IPF, results from recurrent injury to alveolar epithelium that is followed by dysregulated repair.

12 Nov 2019

Beckman Coulter receives BARDA funding to develop novel sepsis detection algorithm

Beckman Coulter, Inc., a Danaher company, today announced that it has initially been awarded a contract of $1.25 million, with potential to be awarded an additional $6.5 million if all contract options are exercised, from the DRIVe (Division of Research, Innovation, and Ventures) established by the Biomedical Advanced Research and Development Authority, under the Office of the Assistant Secretary for Preparedness and Response, within the United States Department of Health and Human Services.

From Beckman Coulter Diagnostics 30 Oct 2019

Study explores how macrophage specialization gets disrupted by liver disease

Every tissue in the human body has an immune cell in it called a macrophage. Macrophages play important roles in the immune system's initial response to bacteria, viruses and wounds.

4 Oct 2019

Dormant HIV reservoirs could be killed with RNA switch

Researchers from the University of California San Diego School of Medicine have found cellular triggers within the immune cells that could be controlled in order to kill dormant HIV-1 reservoirs in individuals with HIV-1.

25 Sep 2019

New biomarkers help predict response to treatment in common brain tumor

Many scientists have noted that there is a link between inflammation or the immune response, and patient survival. One such possible relationship is the association of blood markers and the prognosis in the brain tumor called medulloblastoma.

16 Sep 2019

How tuberculosis progresses: genetic factors play a major role

There are almost 1.8 billion people with tuberculosis bacilli in their body, but only about 5% to 15% develop overt infection, usually within 18 months of initial exposure. The reason behind this selective progression has been sought for decades by scientists from a variety of fields.

5 Sep 2019

Large-scale study maps the genetic underpinnings of early TB progression

While the vast majority of the 1.8 billion people infected with the TB bacterium never experience active disease, an estimated 5 to 15 percent do develop full-blown infections--roughly half of them within 18 months of exposure.

4 Sep 2019

Regulating blood supply to limbs after stroke improves functional recovery

Cutting off and then restoring blood supply to a limb following a stroke reduces tissue damage and swelling and improves functional recovery, according to a new study in mice published in JNeurosci.

From Society for Neuroscience 21 Aug 2019

Defective immune signals could underlie some types of fatal heart disease

Researchers have come up with exciting evidence that confirms the role of abnormal immune signaling in myocarditis.

25 Jul 2019

Disruption of immune cell behavior may spur heart disease, heart failure

On an ice hockey team, the players all start off with identical uniforms, skates and a stick. But if you take one of them, add padding, a glove, and a mask; and switch the stick to one with a larger blade, then you get a goalie.

From Johns Hopkins Medicine 19 Jul 2019

Higher levels of doublets in flow cytometry indicate tuberculosis or dengue fever

Sorting through individual immune cells is a handy way to see how the body responds to disease. For years, researchers around the world have used a technique called flow cytometry to separate different types of immune cells, such as T cells, B cells and monocytes.

26 Jun 2019

Non-classical monocytes directly involved in regulation of immune response

Non-classical monocytes were long thought to play a purely surveillance role in the immune system. With the aid of a novel marker, Ludwig-Maximilians-Universitaet in Munich researchers have now shown that they are directly involved in the regulation of immune response

24 Jun 2019

Researchers uncover new mechanism by which cells communicate in inflammatory processes

A research group from MedUni Vienna and CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences has discovered a new mechanism by which cells communicate in inflammatory processes.

14 Jun 2019

Researchers identify macrophages' pathway to nurture PTEN-deficient glioblastoma

A common genetic deficiency empowers glioblastoma to broadcast a molecular message to the wrong type of immune cell, summoning macrophages that protect and nurture the brain tumor instead of attacking it, researchers at The University of Texas MD Anderson Cancer Center report in Cancer Cell.

11 Jun 2019

Study yields insights into evolutionary dynamics between bacteria and human hosts

Researchers have discovered that humans and great apes possess a receptor on their cells that detects metabolites from bacteria commonly found in fermented foods and triggers movement of immune cells.

From PLOS ONE 28 May 2019