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Secretion of more immune protein protects females against obesity

Associated with poorer mental health outcomes and reduced quality of life, obesity is on the rise in the United States. Currently, more than 30% of American adults are classified as obese.

25 Jul 2023

New drug delivery system may revolutionize treatment of ectopic pregnancy

Researchers in the Oregon State University College of Pharmacy have developed a drug delivery system that shows promise for greatly enhancing the efficacy of the medicine given to women with the life-threatening condition of ectopic pregnancy, which occurs when a fertilized egg implants somewhere other than the lining of the uterus.

24 Jul 2023

Researchers develop novel system to identify new therapeutics for familial hypercholesterolemia

The Mona Lisa, painted by the Italian artist Leonardo da Vinci, is one of the most recognizable paintings in the world. But many people would be surprised to learn that this painting offers the first evidence of a disease called familial hypercholesterolemia (FH).

20 Jul 2023

Study reveals molecular mechanisms of H. pylori-induced gastric carcinogenesis

Helicobacter pylori (H. pylori) infections are commonly associated with abdominal pain, bloating, and acidity. Clinical evidence suggests that infection with H. pylori cagA+ strains dramatically increases the risk of developing gastric cancer.

18 Jul 2023

Study establishes new link between genomic instability and bacterial protein in the urogenital tract

A team of researchers from the University of Maryland School of Maryland's (UMSOM) Institute of Human Virology (IHV), a Center of Excellence of the Global Virus Network (GVN), published new findings that emphasize the crucial role of the urinary and genital tract microbiota in adverse pregnancy outcomes and genomic instability that originate in the womb during fetal development.

17 Jul 2023

Study reveals immune dysregulation in Down syndrome and potential therapeutic strategy

People with Down syndrome, the condition caused by an extra copy of chromosome 21, or trisomy 21, display chronic dysregulation of their immune system, which can contribute to high rates of autoimmune conditions and severe complications from respiratory infections.

17 Jul 2023

New study reveals mast cells' surprising role in allergy-related avoidance behavior

Researchers showed that mast cells and IgE are the key orchestrators of antigen-specific avoidance.

14 Jul 2023

Novel approach: intranasal vaccination strategy targets Omicron COVID-19 variants

Researchers tested the efficacy of a two to three-dose intranasal (IN) regimen of the NDV-HXP-S vaccine.

14 Jul 2023

Macrophages may play a major role in the development of atrial fibrillation

Current treatments for atrial fibrillation (AFib), a common heart condition characterized by fast and irregular beats that can lead to stroke and heart failure, have multiple side effects and are ineffective for preventing AFib recurrence.

13 Jul 2023

IL-9 identified as contributor to viral spread and airway inflammation in COVID-19

Researchers used a K18-hACE2 transgenic (ACE2.Tg) mouse model to demonstrate that interleukin-9 (IL-9).

13 Jul 2023

Mouse model of Hutchinson-Gilford progeria syndrome shows reduction in hepatic H2S levels

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 12, entitled, "Hepatic hydrogen sulfide levels are reduced in mouse model of Hutchinson-Gilford progeria syndrome."

11 Jul 2023

How the brain keeps blood sugar levels in check

The body's blood glucose level needs to be maintained in a relatively narrow range. It cannot be too high, as it can lead to diabetes, and it cannot be too low because it can cause fainting or even death.

11 Jul 2023

New mouse model mimics the development of frailty in older adults

Researchers at the Johns Hopkins University School of Medicine have developed a mouse model that successfully mimics the development of frailty as mammals — likely including people — get older.

11 Jul 2023

The genetics of neurogenic inflammation in rosacea

Researchers identify rare genetic variants in families with rosacea.

11 Jul 2023

FKBP5 deficiency linked to atrial fibrillation

Atrial fibrillation (AFib) is the most common type of heart arrhythmia. This serious condition occurs when the heart beats so fast that the upper chambers of the heart quiver.

6 Jul 2023

New therapy to mitigate fragile X syndrome may be on the horizon

An antisense therapy developed by Joel D. Richter, PhD, Sneha Shah, PhD, and Jonathan K. Watts, PhD, at UMass Chan Medical School and Elizabeth Berry-Kravis, MD, PhD, at RUSH University Medical Center, restores production of the protein FMRP in cell samples taken from patients with fragile X syndrome.

5 Jul 2023

Researchers uncover the role of glutaminase 2 in glucose homeostasis

Glutaminase 2 (GLS2) is a master regulator of glutaminolysis. GLS2 converts glutamine to glutamate, thereby playing a role in cellular energy production. GLS2 is abundant in the liver, and is also found in pancreatic β-cells. However, the role of GLS2 in pancreatic islets – in which both ɑ- and β- cells are present – associated with glucose metabolism is currently unknown.

5 Jul 2023

Resistance training could be a simple and affordable therapy for Alzheimer's patients

Regular physical exercise, such as resistance training, can prevent Alzheimer's disease, or at least delay the appearance of symptoms, and serves as a simple and affordable therapy for Alzheimer's patients.

3 Jul 2023

Ancient retrovirus may be responsible for aggressive brain cancers

The median length of survival after diagnosis of glioblastoma is 14 months, but some of these brain tumors are more aggressive and resistant to treatment than others, and a new study from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine suggests reactivation of an ancient retrovirus may be at least partly to blame.

3 Jul 2023

Cell therapy using genome-edited iPS cells could be a new treatment for Fabry disease

Induced pluripotent stem (iPS) cells have a great impact on biology and medicine, and they are expected to improve regenerative medicine.

3 Jul 2023

Mouse Model News and Research

Secretion of more immune protein protects females against obesity

New drug delivery system may revolutionize treatment of ectopic pregnancy

Researchers develop novel system to identify new therapeutics for familial hypercholesterolemia

Study reveals molecular mechanisms of H. pylori-induced gastric carcinogenesis

Study establishes new link between genomic instability and bacterial protein in the urogenital tract

Study reveals immune dysregulation in Down syndrome and potential therapeutic strategy

New study reveals mast cells' surprising role in allergy-related avoidance behavior

Novel approach: intranasal vaccination strategy targets Omicron COVID-19 variants

Macrophages may play a major role in the development of atrial fibrillation

IL-9 identified as contributor to viral spread and airway inflammation in COVID-19

Mouse model of Hutchinson-Gilford progeria syndrome shows reduction in hepatic H2S levels

How the brain keeps blood sugar levels in check

New mouse model mimics the development of frailty in older adults

The genetics of neurogenic inflammation in rosacea

FKBP5 deficiency linked to atrial fibrillation

New therapy to mitigate fragile X syndrome may be on the horizon

Researchers uncover the role of glutaminase 2 in glucose homeostasis

Resistance training could be a simple and affordable therapy for Alzheimer's patients

Ancient retrovirus may be responsible for aggressive brain cancers

Cell therapy using genome-edited iPS cells could be a new treatment for Fabry disease

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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