Mouse Model News and Research

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Mouse models shed light on the effects of metformin use during pregnancy on offspring

With the rise in gestational diabetes and metabolic disorders during pregnancy, metformin is also being prescribed more frequently.

18 Mar 2024

Study unlocks the mystery of neonatal neutropenia in newborns

Compared to adults, newborns are highly susceptible to infections and these infections can cause serious health complications and even death.

15 Mar 2024

How the brain switches between daydreaming and reality

When we daydream, we must be able to snap back to attention at a moment's notice. Researchers at Boston Children's Hospital uncovered how our brains can do things like react to a question when we're daydreaming: firing activity in part of the brain called the dentate gyrus keeps us focused on what's happening in our environment.

13 Mar 2024

Targeting a non-encoding stretch of RNA may shrink pediatric brain tumors in mice

Targeting a non-encoding stretch of RNA may help shrink tumors caused by an aggressive type of brain cancer in children, according to new research in mice reported March 8 in Cell Reports by Johns Hopkins Kimmel Cancer Center investigators.

13 Mar 2024

Limoncella apple polyphenol extract shines in IBD liver damage study

'Limoncella' apple polyphenol extract (LAPE) shows promise in reducing liver and intestinal inflammation in a mouse model of inflammatory bowel disease (IBD), highlighting potential natural treatment pathways

12 Mar 2024

New “GPS nanoparticle” delivers a genetic punch to the protein implicated in tumor spread

A newly developed "GPS nanoparticle" injected intravenously can home in on cancer cells to deliver a genetic punch to the protein implicated in tumor growth and spread, according to researchers from Penn State.

11 Mar 2024

New research identifies potential drug target to prevent kidney failure

A new study found that retinoic acid receptors (RARa) in the proximal tubules of the kidney play a crucial role in limiting the damaging effects of kidney injury that often lead to kidney failure.

9 Mar 2024

Scientists transform skin cells into functional eggs in mice

New research from Oregon Health & Science University describes the science behind a promising technique to treat infertility by turning a skin cell into an egg that is capable of producing viable embryos.

9 Mar 2024

New PET radiotracer distinguishes diseased tissues based on fructose metabolism

A new PET radiotracer can differentiate diseased tissues from healthy tissues based on fructose metabolism, according to new research published in the March issue of The Journal of Nuclear Medicine.

8 Mar 2024

MIT researchers identify key brain circuit for vocalization control

MIT researchers have discovered a brain circuit that drives vocalization and ensures that you talk only when you breathe out, and stop talking when you breathe in.

7 Mar 2024

Study reveals nerve changes linked to pain and urinary frequency in recurrent UTI sufferers

How sensory nerve sprouting and mast cell activity, driven by nerve growth factor (NGF), contribute to persistent bladder pain and dysfunction in recurrent urinary tract infection (rUTI) cases.

7 Mar 2024

Study reveals surge of a neural-specific protein as the earliest-yet biomarker for Alzheimer's disease

A surge of a neural-specific protein in the brain is the earliest-yet biomarker for Alzheimer's disease, report University of Illinois Urbana-Champaign researchers studying a mouse model of the disease.

6 Mar 2024

New class of antiviral drugs could shield against future viral outbreaks

A University of Alberta research team has uncovered a new class of drugs with the potential to prevent or treat infections in a future viral outbreak.

4 Mar 2024

Unlocking the secrets of T follicular helper cells for better treatment strategies

T follicular helper cells (Tfh) are essential for strong antibody-mediated reactions of our immune system during infections and vaccinations. However, if they get out of control, this can cause diseases such as autoimmunity, allergies or cancer.

1 Mar 2024

Research uncovers key therapeutic target for reversing accelerated atherosclerosis in diabetes

Diabetes accelerates the development of atherosclerosis, increasing the incidence of cardiovascular events.

29 Feb 2024

UMass Amherst study targets aplastic anemia with cell retraining approach

Researchers at the University of Massachusetts Amherst recently released a first-of-its-kind study that focuses on the rare autoimmune disorder aplastic anemia to understand how a subset of cells might be trained to correct the overzealous immune response that can lead to fatal autoimmune disorders.

27 Feb 2024

Breakthrough research unveils β-cell dynamics in Type 1 diabetes

About eight million people live with Type 1 diabetes (T1D) worldwide, a chronic autoimmune condition in which the body attacks and destroys its own insulin-producing β-cells (pronounced "beta") in the pancreas, leading to a lack of insulin and inability to regulate blood sugar.

26 Feb 2024