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New "pseudo cell" formulation could revolutionize treatment of vitreoretinal diseases

Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences and Beijing Chaoyang Hospital have developed a new "pseudo cell" formulation based on self-healing microcapsule-loading exosomes to treat diverse vitreoretinal diseases.

24 Oct 2023

Study reveals how tuberculosis bacteria form cords to resist antibiotics

The ability of Mycobacterium tuberculosis (MTB), a serious respiratory infection, to form snake-like cords was first noted nearly 80 years ago. In a study published October 20 in the journal Cell, investigators report the biophysical mechanisms by which these cords form and demonstrate how several generations of dividing bacteria hang together to create these structures that enable resistance to antibiotics.

20 Oct 2023

Atovaquone "chemical vaccine" for malaria could be more feasible than thought

Johns Hopkins researchers looking to develop a long-acting, injectable malaria preventive using atovaquone have shown in a new study that resistance may not be the challenge scientists thought it was, particularly when using atovaquone as a malaria preventive.

20 Oct 2023

How ketamine treatment elicits long-lasting anti-depressive effects

Researchers discuss the mechanisms responsible for the sustained antidepressant effects of ketamine by examining ketamine-NMDAR interactions.

20 Oct 2023

Brain natriuretic peptide plays a role in activating atopic dermatitis

Researchers from North Carolina State University have pinpointed a particular peptide's role in activating atopic dermatitis, or eczema. The work could lead to more effective treatments for the condition.

19 Oct 2023

Multidrug-resistant E.coli outcompete harmless strains to take over the gut, study reveals

Different strains of E.coli can outcompete one another to take over the gut, a new study reveals.

17 Oct 2023

Mitochondrial protein CHCHD2 plays important role in glioblastoma progression

Glioblastoma is the most common type of brain tumor that affects adults and, unfortunately, still remains incurable. In a new study, researchers have demonstrated that a specific mitochondrial protein plays an important role in glioblastoma, and can therefore be used as a potential target to reduce tumors.

17 Oct 2023

“Goblet cells” play an important role in the development of allergic conjunctivitis

The first step in the development of the allergic conjunctivitis is the penetration of the allergen through the epithelial layer.

17 Oct 2023

New mRNA flu vaccine shows promise: Faster to produce, highly effective in mice

The study evaluates the efficacy of a new quadrivalent mRNA influenza vaccine, finding it to be highly immunogenic and protective in a mouse model. Compared to traditional vaccines, the mRNA-based option offers advantages like reduced production time and elimination of the risk of growth-promoting mutations.

15 Oct 2023

New radio-theranostics approach shows promise in the fight against pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers worldwide, with a 5-year survival rate of less than 10%. Many PDAC tumors in early stage go undetected because they are not found using conventional imaging methods, including fluorodeoxyglucose positron emission tomography (PET) scans.

15 Oct 2023

Deep brain stimulation improves memory and promotes neuron growth in Rett mice

A recent study from the lab of Dr. Jianrong Tang, associate professor at Baylor College of Medicine and principal investigator at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital shows that deep brain stimulation (DBS) of a specific brain region results in a significant and sustained improvement of memory in Rett mice.

13 Oct 2023

Accelerating drug discovery with analytical R&D solutions

In this interview, Thermo Fisher Scientific discusses how to accelerate drug discovery through analytical R&D.

From Thermo Fisher Scientific – Materials & Structural Analysis 12 Oct 2023

Mucin glycosylation plays crucial role in protecting against obesity and intestinal inflammation

Located in the mucus layer that lines the gastrointestinal tract, mucins-;proteins with attached sugar molecules-;play a key role in combating bacterial infection and providing a safe haven to friendly gut bacteria through unknown mechanisms.

11 Oct 2023

Study highlights YB-1 targeting as novel treatment approach for pleural mesothelioma

Pleural mesothelioma (PM) is mainly caused by asbestos exposure and characterized by poor prognosis and limited therapeutic options.

11 Oct 2023

Stress-induced ribosome dysregulation may underlie depression

A group of ribosomal protein genes connects animal models of depression to human patients with major depressive disorder.

10 Oct 2023

Gut defenders: How T-cell intraepithelial lymphocytes guard against colon cancer

In the latest research published in Science Immunology, experts delve into the gene expression patterns of distinct intraepithelial lymphocyte populations in various gastrointestinal tract regions. Key findings reveal the roles of T-cell IELs in detecting infections and ensuring the gut's barrier integrity, with a special emphasis on their function in combating colon cancer.

9 Oct 2023

Study uncovers novel therapeutic target for osteoblastic lesions in prostate cancer bone metastasis

In a study published in the journal Genes & Diseases, researchers from Army Medical University and Shenzhen University investigated the pivotal role of miR-18a-5p, a microRNA, in the development and progression of osteoblastic lesions resulting from prostate cancer (PCa) bone metastasis.

9 Oct 2023

Mouse Model News and Research

New "pseudo cell" formulation could revolutionize treatment of vitreoretinal diseases

Study reveals how tuberculosis bacteria form cords to resist antibiotics

Atovaquone "chemical vaccine" for malaria could be more feasible than thought

How ketamine treatment elicits long-lasting anti-depressive effects

Brain natriuretic peptide plays a role in activating atopic dermatitis

Multidrug-resistant E.coli outcompete harmless strains to take over the gut, study reveals

Mitochondrial protein CHCHD2 plays important role in glioblastoma progression

“Goblet cells” play an important role in the development of allergic conjunctivitis

New mRNA flu vaccine shows promise: Faster to produce, highly effective in mice

New radio-theranostics approach shows promise in the fight against pancreatic cancer

Deep brain stimulation improves memory and promotes neuron growth in Rett mice

Accelerating drug discovery with analytical R&D solutions

Mucin glycosylation plays crucial role in protecting against obesity and intestinal inflammation

Study highlights YB-1 targeting as novel treatment approach for pleural mesothelioma

Stress-induced ribosome dysregulation may underlie depression

Gut defenders: How T-cell intraepithelial lymphocytes guard against colon cancer

Study uncovers novel therapeutic target for osteoblastic lesions in prostate cancer bone metastasis

Researchers develop innovative treatment option for therapy-resistant epilepsy

Grape consumption improves key markers of eye health in older adults

Effectiveness of Lactobacillus in treating inflammatory bowel disease

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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