Myeloperoxidase News and Research

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Myeloperoxidase (MPO) is a peroxidase enzyme most abundantly present in neutrophil granulocytes (a subtype of white blood cells). It is a lysosomal protein stored in azurophilic granules of the neutrophil. MPO has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus.

Limoncella apple polyphenol extract shines in IBD liver damage study

'Limoncella' apple polyphenol extract (LAPE) shows promise in reducing liver and intestinal inflammation in a mouse model of inflammatory bowel disease (IBD), highlighting potential natural treatment pathways

12 Mar 2024

Moderate wine consumption may reduce the risk of some cancers

A meta-analysis published in Frontiers in Nutrition finds no link between moderate wine consumption and increased cancer risk; instead, it suggests that wine may have protective effects against certain types of tumors. Further research is needed to confirm these findings and understand the mechanisms involved.

26 Oct 2023

Is a vegan diet a healthy choice for kids?

In a comprehensive review published in Critical Reviews in Food Science and Nutrition, scientists analyzed the health implications of vegan diets in children and adolescents. The study reveals both benefits and concerns, highlighting lower cholesterol levels but potential nutritional deficiencies that might affect bone health.

10 Oct 2023

Ginger shows promise as a natural defense against autoimmune diseases

Comprehensive study reveals that whole ginger extracts have a significant impact on inhibiting neutrophil hyperactivity, a key factor in autoimmune diseases like APS and lupus. Consuming ginger for just a week showed promising results in both animal models and human trials, positioning it as a natural and affordable treatment option for a range of autoimmune disorders.

2 Oct 2023

Color of the phlegm can indicate degree of lung inflammation in patients with bronchiectasis

The color of the phlegm from patients with the lung disease bronchiectasis can indicate the degree of inflammation in their lungs and predict their future outcomes, according to new research presented at the European Respiratory Society International Congress in Milan, Italy.

11 Sep 2023

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Researchers described the preclinical profile of JT002, a novel and orally bioavailable small molecule inhibitor of the NLRP3 inflammasome.

24 Aug 2023

Is there an association between dairy intake and markers of gastrointestinal inflammation?

Researchers determined the links between dairy consumption and gastrointestinal (GI) inflammatory markers.

10 Aug 2023

Role of M2 macrophage-derived exosomes in controlling neutrophil-mediated tissue injury in sepsis

Researchers investigate whether M2 macrophage-derived exosomes could prevent inflammation-associated damage during sepsis.

7 Aug 2023

Are a high-refined carbohydrate diet and the alterations resulting from its intake linked to small intestine changes?

Researchers investigated whether a high-refined carbohydrate diet and associated metabolic alterations could cause small intestinal dysregulation.

27 Jun 2023

Genetic insights unveil promising therapeutic targets for critical COVID-19

Critical COVID-19 illness reveals genetic associations with immunomodulatory therapies, as identified in a comprehensive analysis of 24,202 cases. This study uncovers novel genome-wide significant associations, highlighting potential druggable targets for inflammatory signaling, immunometabolism, and viral replication, offering insights into therapeutic implications.

21 May 2023

Boosting gut health with short-chain fatty acids

Research paper provides an overview of short-chain fatty acids (SCFAs) and their role in regulating gut homeostasis. It also discusses SCFA-producing bacteria and potential therapeutic approaches to boost SCFA levels in the gut to treat related diseases.

9 May 2023

Study finds cannabis vaping more harmful than nicotine vaping

A study published in the journal Thorax compares the pulmonary effects of vaping nicotine and cannabis. The study finds that cannabis is more harmful to lung health than nicotine.

5 Mar 2023

Study identifies the essential genetic and immunologic perturbations occurring in patients with long COVID lung fibrosis

Researchers elucidated immunologic and genetic perturbations in long COVID patients with pulmonary fibrosis.

3 Mar 2023

Natural product with grape seed extracts, lactic acid, and pea protein could effectively manage bacterial vaginosis

Researchers evaluate the efficacy of using a product comprising lactic acid, grape seed extract, and pea protein in managing bacterial vaginosis in vivo.

28 Feb 2023

Why do some people develop persistent lung sequelae after severe COVID-19?

Clinical presentation following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from mild self-limiting illness to severe respiratory failure. Many studies have analyzed the early acute phases of coronavirus disease 2019(COVID-19), but few focused on the longer-term sequelae following infection.

2 Jan 2023

Low-density granulocytes are phenotypically altered in people with long-COVID

In a recent study posted to the bioRxiv* preprint server, researchers characterized low-density granulocyte (LDG) neutrophil (NP) proportion among individuals up to 14 months post-SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) infection.

28 Oct 2022

Myeloperoxidase News and Research

Limoncella apple polyphenol extract shines in IBD liver damage study

Moderate wine consumption may reduce the risk of some cancers

Is a vegan diet a healthy choice for kids?

Ginger shows promise as a natural defense against autoimmune diseases

Color of the phlegm can indicate degree of lung inflammation in patients with bronchiectasis

Small molecule inhibitor of the NLRP3 inflammasome for treating autoinflammatory diseases

Is there an association between dairy intake and markers of gastrointestinal inflammation?

Role of M2 macrophage-derived exosomes in controlling neutrophil-mediated tissue injury in sepsis

Are a high-refined carbohydrate diet and the alterations resulting from its intake linked to small intestine changes?

Genetic insights unveil promising therapeutic targets for critical COVID-19

Boosting gut health with short-chain fatty acids

Study finds cannabis vaping more harmful than nicotine vaping

Study identifies the essential genetic and immunologic perturbations occurring in patients with long COVID lung fibrosis

Natural product with grape seed extracts, lactic acid, and pea protein could effectively manage bacterial vaginosis

Why do some people develop persistent lung sequelae after severe COVID-19?

Low-density granulocytes are phenotypically altered in people with long-COVID

COVID-19 and the gut

Overview of the roles of neutrophils in systemic autoimmune and autoinflammatory diseases

Monkeypox virus infection and its persistence in the testes of infected crab-eating macaques

Amplification of venous thromboembolism risk by COVID-19 among malignancy patients

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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