Neurodegeneration News and Research

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Neurodegeneration is the umbrella term for the progressive loss of structure or function of neurons, including death of neurons.

Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

Autophagy, which declines with age, may hold more mysteries than researchers previously suspected. In the January 4th issue of Nature Aging, it was noted that scientists from the Buck Institute, Sanford Burnham Prebys and Rutgers University have uncovered possible novel functions for various autophagy genes, which may control different forms of disposal including misfolded proteins-;and ultimately affect aging.

4 Jan 2024

Natural compounds show promise in modulating heme breakdown, offering new therapeutic avenues

Study explores the impact of natural compounds on bilirubin production and heme catabolic pathway modulation, highlighting their potential in treating neurodegenerative and cardiovascular diseases.

3 Jan 2024

Living alone? Adopting a pet might help slow cognitive decline among older adults

Researchers investigated the association between pet ownership and cognitive decline in the elderly.

3 Jan 2024

Enlarged perivascular spaces in infancy associated with sleep problems and autism risk

Throughout the day and night, cerebrospinal fluid (CSF) pulses through small fluid-filled channels surrounding blood vessels in the brain, called perivascular spaces, to flush out neuroinflammation and other neurological waste.

2 Jan 2024

Increased β-amyloid accumulation may be linked to Alzheimer’s dementia risk in oldest of the old

A new study indicates that severity of amyloid deposition in the brain -; not just age -; may be key to determining who will benefit from new anti-amyloid therapies to delay the progression of Alzheimer's disease.

26 Dec 2023

Gamma stimulation may improve memory and cognition in people with Alzheimer's disease

A surprising MIT study published in Nature at the end of 2016 helped to spur interest in the possibility that light flickering at the frequency of a particular gamma-band brain rhythm could produce meaningful therapeutic effects for people with Alzheimer's disease.

20 Dec 2023

Study reveals extensive postnatal neuronal migration in human entorhinal cortex

The human brain continues to be built after we are born for far longer than previously recognized, suggests research by Shawn Sorrells, assistant professor of neuroscience in the Kenneth P. Dietrich School of Arts and Sciences.

20 Dec 2023

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.

19 Dec 2023

Science’s Breakthrough of the Year: GLP-1 agonists can blunt obesity-associated health problems

Science has named the development of glucagon like peptide-1 (GLP-1) agonists and this year's discovery that these drugs can blunt obesity-associated health problems as its 2023 Breakthrough of The Year.

15 Dec 2023

Unlocking the secrets of our "dark genome": Scientists crack the code of LINE-1

A multidisciplinary study published in Nature has elucidated the structure of the machinery responsible for writing much of our "dark genome" -; the 98 percent of our DNA that has largely unknown biological function.

14 Dec 2023

Physical and social activities may hold the secret to sharper memories in old age

Physical and social activities in old age have a protective effect on the entorhinal cortex, researchers at UZH have shown.

14 Dec 2023

Colombian family's Alzheimer's anomaly offers insights into disease pathogenesis and prevention

Alzheimer's disease has plagued one large Colombian family for generations, striking down half of its members in the prime of life.

11 Dec 2023

Novel molecular link between vitamin B12 and multiple sclerosis revealed in astrocytes

For decades, scientists have noted an intriguing similarity between a deficiency in vitamin B12 – an essential nutrient that supports healthy development and functioning of the central nervous system (CNS) – and multiple sclerosis (MS), a chronic disease in which the body's immune system attacks the CNS and which can produce neurodegeneration.

11 Dec 2023

MIT scientists develop nanoparticles to reduce inflammation in the brain

Some Covid-19 vaccines safely and effectively used lipid nanoparticles (LNPs) to deliver messenger RNA to cells. A new MIT study shows that different nanoparticles could be used for a potential Alzheimer's disease (AD) therapy.

11 Dec 2023

Researchers develop novel exosome-based drug delivery system to treat Alzheimer's disease

A research team led by Hong Kong Baptist University (HKBU) has developed a novel drug delivery system for Alzheimer’s disease (AD).

11 Dec 2023

Irregular sleep patterns linked to cognitive decline in older adults, study shows

Study finds that short sleep duration and high variability in sleep patterns are significantly associated with cognitive impairment in older adults, highlighting the importance of consistent sleep for cognitive health.

5 Dec 2023

New insights into the interplay between prions and TDP-43 in neurodegenerative pathology

Neurodegenerative diseases are characterized by the deposition of clumped proteins in the brain and progressive neuronal cell death.

4 Dec 2023

Abnormal myelin, not loss of myelin, may drive axon degeneration in myelin diseases

Myelin is an insulating sheath around axons - the processes connecting nerve cells - that is mostly composed of lipids and proteins.

28 Nov 2023

Research links soccer heading to decline in the brain microstructure and function

New research being presented this week at the annual meeting of the Radiological Society of North America (RSNA) links soccer heading – where players hit the ball with their head – to a measurable decline in the microstructure and function of the brain over a two-year period.

28 Nov 2023

JMU Würzburg professor wins ERC Consolidator Grant to advance research on ferroptosis

With the coveted Consolidator Grants totalling two million euros, the European Research Council (ERC) supports outstanding scientists whose work promises further top achievements. José Pedro Friedmann Angeli, Professor of Translational Cell Biology at Rudolf Virchow Centre - Centre for Integrative and Translational Bioimaging at Julius-Maximilians-Universität (JMU) Würzburg, now belongs to this group.

23 Nov 2023

Neurodegeneration News and Research

Further Reading

Early-acting autophagy genes extend lifespan through alternative "garbage disposal" pathway in neurons

Natural compounds show promise in modulating heme breakdown, offering new therapeutic avenues

Living alone? Adopting a pet might help slow cognitive decline among older adults

Enlarged perivascular spaces in infancy associated with sleep problems and autism risk

Increased β-amyloid accumulation may be linked to Alzheimer’s dementia risk in oldest of the old

Gamma stimulation may improve memory and cognition in people with Alzheimer's disease

Study reveals extensive postnatal neuronal migration in human entorhinal cortex

Novel adaptations and functions of human LINE-1 revealed by structural analysis and inhibition

Science’s Breakthrough of the Year: GLP-1 agonists can blunt obesity-associated health problems

Unlocking the secrets of our "dark genome": Scientists crack the code of LINE-1

Physical and social activities may hold the secret to sharper memories in old age

Colombian family's Alzheimer's anomaly offers insights into disease pathogenesis and prevention

Novel molecular link between vitamin B12 and multiple sclerosis revealed in astrocytes

MIT scientists develop nanoparticles to reduce inflammation in the brain

Researchers develop novel exosome-based drug delivery system to treat Alzheimer's disease

Irregular sleep patterns linked to cognitive decline in older adults, study shows

New insights into the interplay between prions and TDP-43 in neurodegenerative pathology

Abnormal myelin, not loss of myelin, may drive axon degeneration in myelin diseases

Research links soccer heading to decline in the brain microstructure and function

JMU Würzburg professor wins ERC Consolidator Grant to advance research on ferroptosis

Aneuro: A Year of Neuroscience in Review eBook

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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