Neurodegenerative Diseases News and Research

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Coaxing human embryonic stem cells to make dopamine

For all of the promise embryonic stem cells hold for therapies for neurodegenerative diseases such as Parkinson's disease, they are notoriously difficult to use.

28 Nov 2005

Protein alpha-synuclein associated with causing neurodegenerative conditions may actually protects against neurodegeneration

Researchers at UT Southwestern Medical Center have discovered that a protein associated with causing neurodegenerative conditions may, when appearing in normal amounts, actually protects against neurodegeneration.

7 Nov 2005

Scientists find new mechanism by which brain cells can be damaged during chronic neurodegenerative diseases

Scientists at the University of Rochester Medical Center have targeted a new culprit and method of attack on neurologic functions in diseases such as Alzheimer's and dementia associated with HIV.

7 Nov 2005

Protein called CHIP helps untangle protein misfolding in brain disease

Keeping the body and mind healthy depends on keeping cells healthy and functioning. This means that cells need a very robust quality-control system to repair or remove damaged or misshapen proteins. Protein handling is especially important in neurons because damage or death of brain cells causes neurological disease.

1 Nov 2005

Northwestern University move closer to new therapies for neurodegenerative disease

French neurologist Jean-Martin Charcot first described amyotrophic lateral sclerosis (ALS) in 1869, but, nearly 140 years later, little is known about the cause of the devastating neurodegenerative disease, and there is no cure.

27 Oct 2005

Aging may intensify and prolong feeling run down when common infections like the flu occur

A new study, done with mice and published in the Federation of the American Societies of Experimental Biology Journal, suggests that miscommunication between the immune system and brain may be to blame for extended sickness symptoms and other cognitive disorders in elderly people and animals with an infection.

11 Oct 2005

Possible molecular origin of at least nine human diseases of nervous system degeneration

These neurodegenerative diseases, including Huntington's disease, share an abnormal deposit of proteins inside nerve cells. This deposition of protein results from a kind of genetic stutter within the cell's nucleus asking for multiple copies of the amino acid glutamine, a building block of protein structure.

26 Sep 2005

Prions rapidly 'remodel' good protein into bad

Two Brown Medical School biologists have figured out the fate of healthy protein when it comes in contact with the infectious prion form in yeast: The protein converts to the prion form, rendering it infectious. In an instant, good protein goes bad.

19 Sep 2005

Scientists characterize the most infectious prion protein particles

A new study of prions - apparently malformed proteins that initiate deadly brain diseases such as Creutzfeldt-Jakob disease in humans - has yielded surprising information about how the size of prions relates to their infectivity.

10 Sep 2005

Study points to link to neurodegenerative disease target

A University of California - San Francisco (UCSF) study has found that a specific signaling link between neurons and muscles in the fruit fly is essential for keeping the insect's nervous system stable.

1 Sep 2005

Strawberries most effective at inducing cancer cell death

Strawberries may be the most effective of the five most commonly consumed berries at inducing cancer cell death, according to a recent study conducted at the UCLA Center for Human Nutrition.

10 Aug 2005

New theory as to why some people die during sleep

According to scientists the reason why some people stop breathing fatally in their sleep, is because a cumulative loss of cells in the area of the brain that controls breathing triggers a condition called central sleep apnoea.

9 Aug 2005

Nighttime dying linked to sleep apnea from brain cell loss

Aim to grow old and die peacefully in your sleep? Be careful what you wish for. A new UCLA study suggests that some people die in their sleep because they stop breathing due to a cumulative loss of cells in the brain's breathing command-post. The online edition of Nature Neuroscience reports the findings.

7 Aug 2005

Aging and gene expression in the primate brain

While medical science and a healthy lifestyle can help increase life expectancy, many aspects of aging and longevity are beyond our control. Published this week in the open-access journal PLoS Biology, Michael Eisen and colleagues shed light on these genetic factors by identifying sets of genes whose expression changes with age in human and chimp brains.

2 Aug 2005

Single prenatal dose of methamphetamine enough to cause long-term neurodevelopmental problems in babies

In research published in the August issue of Free Radical Biology and Medicine, U of T pharmacy and pharmacology professor Peter Wells and his colleagues determined that exposing pregnant mice only once to methamphetamine led to delivery of offspring with long-term neurodevelopmental problems, including reduced motor co-ordination.

26 Jul 2005

New understanding of degeneration of brain cells in patients with Alzheimer's, Huntington's, and Parkinson's diseases

A ground-breaking new research approach to understanding the cellular processes of Alzheimer's and other degenerative diseases has revealed a promising pathway to the development of new types of drugs for these diseases.

11 Jul 2005

Novel inhibitor offsets neurotoxic effects of tPA - possible new stroke treatments

A research team lead by the Burnham Institute has synthesized and tested a new series of inhibitors that can prevent the type of nerve cell injury and death associated with many neurodegenerative diseases and stroke.

6 Jul 2005

New clue to the causes of neurodegenerative diseases

Scientists funded by the Medical Research Council (MRC), the Wellcome Trust, BBSRC - the Biotechnology and Biological Sciences Research Council and the EU have made an important discovery about the mechanisms underlying degenerative brain diseases.

26 Jun 2005

Researchers isolate substance most responsible for the tissue damage that follows initial spinal cord injury

Purdue University researchers may have isolated the substance most responsible for the tissue damage that follows initial spinal cord injury, a discovery that could also improve treatments for a host of other neurodegenerative conditions.

21 Jun 2005

Enzyme family plays role in Alzheimer's

The route to a treatment for Alzheimer's disease may have become more straightforward with the discovery that a key enzyme known to have a major role in this disease is in fact part of a family of enzymes. Only some family members play a role in the progression of this brain-wasting illness, new research at the University of Toronto has found.

20 Jun 2005