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Novel treatment approach to halt epilepsy progression identified

Only a very small percentage of neurons show changes after an epileptic seizure in mice, but these alterations can be permanent and trigger future seizures that can affect the whole brain and lead to impaired cognition, like memory and learning, according to new research from the Perelman School of Medicine at the University of Pennsylvania.

22 Mar 2024

Research provides first evidence for a possible cause of familial ALS

Amyotrophic lateral sclerosis (ALS) is a degenerative disease. The neurons responsible for movement begin to die and muscle control is progressively lost, leading to a fatal outcome.

22 Mar 2024

Study shows cellular, molecular overlaps in ALS and FTLD

On the surface, the movement disorder amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and the cognitive disorder frontotemporal lobar degeneration (FTLD), which underlies frontotemporal dementia, manifest in very different ways. In addition, they are known to primarily affect very different regions of the brain.

22 Mar 2024

Mapping the aging brain's protein landscape

Researchers at LMU and the SyNergy Cluster of Excellence have analyzed how the proteome of specific brain cells changes as we age.

22 Mar 2024

Researchers discover the lungs communicate directly with the brain to induce sickness symptoms

University of Calgary researchers have discovered the lungs communicate directly with the brain when there is an infection.

21 Mar 2024

Innovative study on asthma inflammation funded by NIH/NIAID grant

In a significant stride for respiratory medicine, Lundquist Institute (TLI) investigator Nicholas Jendzjowsky, PhD, has been awarded a prestigious grant from the National Institute of Health/National Institute of Allergy and Infectious Diseases (NIH/NIAID).

21 Mar 2024

Inhibiting neurons involved in the body's stress response may reduce alcohol use

Neuroscientists at Scripps Research have found that inhibiting neurons involved in the body's stress response may reduce alcohol consumption in people who have both post-traumatic stress disorder (PTSD) and alcohol use disorder (AUD)-;even if they still experience trauma-related anxiety.

21 Mar 2024

Scientists shed light on key immune regulators involved in Alzheimer’s and other disorders of lipid-rich tissues

Using novel genetic and genomic tools, researchers at the Icahn School of Medicine at Mount Sinai have shed light on the role of immune cells called macrophages in lipid-rich tissues like the brain, advancing our understanding of Alzheimer's and other diseases.

21 Mar 2024

AI analyzes lung ultrasound images to spot COVID-19

Artificial intelligence can spot COVID-19 in lung ultrasound images much like facial recognition software can spot a face in a crowd, new research shows.

20 Mar 2024

Investigational gene therapy shows promise for rare childhood neurodegenerative disease

An investigational gene therapy for a rare neurodegenerative disease that begins in early childhood, known as giant axonal neuropathy (GAN), was well tolerated and showed signs of therapeutic benefit in a clinical trial led by the National Institutes of Health.

20 Mar 2024

Aging affects regulatory T cells' ability to promote myelin regeneration

Regulatory T lymphocytes are cells that are responsible for regulating the immune system and have regenerative functions in many contexts, including myelin restoration.

20 Mar 2024

Whole-brain imaging data provides insights into roundworm neural activity

Joint research led by Yu Toyoshima and Yuichi Iino of the University of Tokyo has demonstrated individual differences in and successfully extracted commonalities from the whole-brain activity of roundworms.

15 Mar 2024

Research provides insight into how the brain translates motivation into goal-oriented behavior

Hunger can drive a motivational state that leads an animal to a successful pursuit of a goal -; foraging for and finding food.

15 Mar 2024

Microfluidic chips advance neurodegenerative disease research

Researchers review the role of microfluidic chip models in understanding neurodegenerative diseases, offering insights into the disease mechanisms and potential for drug development through innovative lab-on-a-chip technologies.

14 Mar 2024

Innovative multimodal, non-invasive brain monitoring to enhance ECMO patient care

Extracorporeal membrane oxygenation (ECMO) can be a life-saving therapy for patients with acute heart or lung failure.

14 Mar 2024

Neurobiologists unravel how stress triggers generalized fear

Our nervous systems are naturally wired to sense fear. Whether prompted by the eerie noises we hear alone in the dark or the approaching growl of a threatening animal, our fear response is a survival mechanism that tells us to remain alert and avoid dangerous situations.

14 Mar 2024

Study reveals TDP-43 protein's key role in blood vessel formation and integrity

Defects in the blood vessel network of the central nervous system have been linked to early symptoms of neurodegenerative diseases such as Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

13 Mar 2024

Age-related changes in the shape of brain neurons lead to middle-age obesity

Nagoya University researchers and their colleagues in Japan have found that middle-age obesity is caused by age-related changes in the shape of neurons in the hypothalamus, a region of the brain that controls metabolism and appetite.

13 Mar 2024

Novel dual-target CAR T cell therapy shows promise in treating recurrent glioblastoma

Targeting two brain tumor-associated proteins-;rather than one-;with CAR T cell therapy shows promise as a strategy for reducing solid tumor growth in patients with recurrent glioblastoma (GBM), an aggressive form of brain cancer, according to early results from the first six patients treated in an ongoing Phase I clinical trial led by researchers from the Perelman School of Medicine at the University of Pennsylvania and Penn Medicine's Abramson Cancer Center.

13 Mar 2024

Protein Kdm1a plays a crucial role in preserving neuronal identity, study shows

Epigenetic processes allow different cell types to emerge from a single genome. Throughout development, cells differentiate and acquire distinct characteristics by expressing the same genome in different ways.

12 Mar 2024