Neuropathic Pain News and Research

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Neuropathic pain is a type of pain that is caused by damage to the nervous system following an injury or illness and affects approximately 1% of the population.

Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems -; prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia.

9 Apr 2024

Global health burden of neurological conditions is much greater than previously understood, study reveals

Globally, the number of people living with, or dying from, neurological conditions such as stroke, Alzheimer's disease and other dementias, and meningitis has risen substantially over the past 30 years due to the growth and ageing of the global population as well as increased exposure to environmental, metabolic, and lifestyle risk factors.

18 Mar 2024

Study highlights growing burden of neurological disorders worldwide

Globally, the number of people living with, or dying from, neurological conditions such as stroke, Alzheimer's disease and other dementias, and meningitis has risen substantially over the past 30 years due to the growth and aging of the global population as well as increased exposure to environmental, metabolic, and lifestyle risk factors.

15 Mar 2024

New approach to treating neuropathic pain offers the possibility of non-opioid pain relief for millions

Researchers investigated the selective activity of sigmoid 2 receptor (σ2R) or transmembrane protein 97 (TMEM97) ligands on murine neuropathic pain models, their effects on nociceptive neurons and the mechanism of action after 24 hours.

5 Feb 2024

Researchers discover non-opioid therapeutic for relieving neuropathic pain

Among the most difficult types of pain to alleviate is neuropathic pain, pain that is usually caused by damage to nerves in various body tissues, including skin, muscle and joints.

31 Jan 2024

Embracing mindfulness to combat life’s stressors and optimize cognitive performance

Professor Andra Smith, from the School of Psychology at the Faculty of Social Sciences, has combined her research and her personal experience with mindfulness to teach the course Neuroscience of Mindfulness: Neurons to Wellness.

27 Jan 2024

Higher antioxidant intake linked to lower back pain risk in women, study finds

Study investigates the link between dietary antioxidant intake and low back pain, revealing that higher antioxidant levels, particularly selenium and zinc, may reduce the likelihood of low back pain in American women.

16 Jan 2024

Widespread pain makes exercise a challenge for some patients with multiple sclerosis

For patients with multiple sclerosis, a regular exercise routine is important for managing symptoms. Due to different causes of chronic pain though, physical exercise can be more difficult for some.

10 Jan 2024

Early targeted muscle reinnervation cuts chronic pain after amputation

Performed early – at the time of amputation – a procedure called targeted muscle reinnervation (TMR) can reduce pain scores and prevent complications related to abnormal nerve regrowth, suggests a study in the January issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). The journal is published in the Lippincott portfolio by Wolters Kluwer.

4 Jan 2024

Eating your way out of pain: How your gut microbiota and diet can help manage chronic discomfort

A recent study in the Nutrients journal employs bibliometrics to explore how nutrition impacts the relationship between gut microbiota and chronic pain. The research highlights the potential of probiotics and prebiotics in managing pain conditions and underscores the need for further studies to understand the interplay between diet, gut health, and chronic pain.

28 Aug 2023

New drug shows promise for treating chronic neuropathic pain

A non-opioid designer molecule for treating chronic neuropathic pain by calming hyperactive pain-sensing neurons in the peripheral nervous system has had promising results in a preclinical study conducted by researchers at Weill Cornell Medicine and the Burke Neurological Institute.

2 Aug 2023

Scrambler therapy: A new non-invasive treatment for chronic pain

A new review paper co-authored by two Johns Hopkins pain experts suggests that scrambler therapy, a noninvasive pain treatment, can yield significant relief for approximately 80%–90% of patients with chronic pain, and it may be more effective than another noninvasive therapy: transcutaneous electrical nerve stimulation (TENS).

31 Jul 2023

Brazilian researchers identify new way to stop excessive inflammation in COVID-19

Researchers at the University of São Paulo (USP) in Brazil have identified a new class of molecules capable of stopping the excessive inflammation typical of the severe form of COVID-19 without impairing the immune response to SARS-CoV-2, the virus that causes the disease.

25 Jul 2023

Researchers identify brain signatures for chronic pain in a small group of individuals

For the first time, researchers have recorded pain-related data from inside the brain of individuals with chronic pain disorders caused by stroke or amputation (phantom limb pain).

22 May 2023

Neuropathic pain study uncovers pathophysiological mechanism and promising therapeutic target

Neuropathic pain -; abnormal hypersensitivity to stimuli -; is associated with impaired quality of life and is often poorly managed. Estimates suggest that 3 percent to 17 percent of adults suffer from neuropathic pain, including a quarter of people with diabetes and a third of people with HIV.

5 May 2023

Neuropathic Pain News and Research

Further Reading

Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Global health burden of neurological conditions is much greater than previously understood, study reveals

Study highlights growing burden of neurological disorders worldwide

New approach to treating neuropathic pain offers the possibility of non-opioid pain relief for millions

Researchers discover non-opioid therapeutic for relieving neuropathic pain

Embracing mindfulness to combat life’s stressors and optimize cognitive performance

Higher antioxidant intake linked to lower back pain risk in women, study finds

Widespread pain makes exercise a challenge for some patients with multiple sclerosis

Early targeted muscle reinnervation cuts chronic pain after amputation

Eating your way out of pain: How your gut microbiota and diet can help manage chronic discomfort

New drug shows promise for treating chronic neuropathic pain

Scrambler therapy: A new non-invasive treatment for chronic pain

Brazilian researchers identify new way to stop excessive inflammation in COVID-19

Researchers identify brain signatures for chronic pain in a small group of individuals

Neuropathic pain study uncovers pathophysiological mechanism and promising therapeutic target

Spinal cord stimulation may help reduce chronic pain in people undergoing active cancer treatment

Interferon autoantibodies not implicated in long-COVID

Exploring biodistribution of cannabidiol nanoparticles and nanoemulsion after intrathecal administration

Some antidepressants may be effective in treating chronic pain, but others lack effectiveness

A more nuanced approach is needed when prescribing antidepressants for pain, researchers say

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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