Nitric Oxide News and Research

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Caution against FDA approval of race-based pharmaceutical

New York University Sociologist Troy Duster concludes that a pharmaceutical to combat heart disease among blacks is based on faulty research and urges the Food and Drug Administration to obtain more reliable data before approving the drug.

27 Feb 2005

Changing chemistry helps explain estrogen threat to the heart

A piece of the topical puzzle of how estrogen goes from protecting women from heart disease to apparently increasing their risk later in life may have been found.

16 Feb 2005

New understanding of the causes for symptoms of sickle cell disease

A new understanding of the causes for symptoms of sickle cell disease, a condition affecting one in every 600 African-Americans, has resulted from a study by researchers at Duke University Medical Center and Howard Hughes Medical Institute (HHMI). Their findings may lead to a new, more direct method for treating the disease, they said.

31 Jan 2005

Viagra protects cardiomyocytes against cell death

Virginia Commonwealth University researchers have shown that a widely used drug for treating erectile dysfunction, Viagra, reduces the death of heart cells under heart attack-like conditions in a laboratory model.

31 Jan 2005

Sildenafil restores cognitive function in rats after liver failure

A study involving rats reveals the mechanism responsible for learning impairment due to liver failure and shows that sildenafil restores cognitive function.

19 Jan 2005

Compounds in Christmas trees could help treat arthritis and pain

Researchers have identified a group of anti-inflammatory compounds in the bark of the Scotch pine - widely used for Christmas trees - that they say could be developed into food supplements or drugs for treating arthritis and pain.

13 Dec 2004

Smoking and high salt intake, but not tea and alcohol, implicated in acid reflux

Smoking and a high dietary salt intake significantly increase the risk of acid reflux, but tea and alcohol, often thought to be culprits, seem to have little impact, finds a large study in Gut.

10 Nov 2004

BiDil demonstrates significant improvement in survival rates in African American heart failure patients

"African Americans suffer disproportionately from heart failure and until A-HeFT have been underrepresented in heart failure trials," said Malcolm Taylor, M.D., Chair of the Association of Black Cardiologists Committee on Heart Failure. "A-HeFT represents a significant step forward in addressing these disparities."

9 Nov 2004

Red wine delivered though an aerosol for COPD, asthma, and possibly even arthritis

Homing in on mechanisms for the reported effectiveness of resveratrol, which is found in red wine, researchers at Imperial College London, England, confirmed its broad anti-inflammatory action, and found potential for applications in chronic obstructive pulmonary disease (COPD), asthma, and possibly even arthritis.

29 Oct 2004

Impaired endothelial function is an early indicator of atherosclerosis

Impaired endothelial function is an early indicator of atherosclerosis according to a study of healthy people followed from childhood to young adulthood reported in Circulation: Journal of the American Heart Association.

25 Oct 2004

New medication to prevent colon cancer

A Stony Brook University researcher is testing a new form of aspirin--one that is much more potent than its commercially available counterpart, but with almost none of the side effects--to determine whether it can be used to prevent colon cancer in patients who are prone to the disease.

21 Oct 2004

Research shows C. botulinum uses SONO to detect nitric oxide

A deadly bacterium's defense against a mortal molecular enemy illuminates the origins and structure of a vital protein involved in human cell signaling, University of Texas Medical School scientists report in Science Express.

8 Oct 2004

Potential new drug for the treatment of sickle cell disease

The results were published in the June 2004 issue of The British Journal of Haematology (BJH). MX-1520 is a prodrug of vanillin, a very popular food additive generally regarded as safe (GRAS) by the FDA.

13 Sep 2004

Inhaled nitrite spray may help babies diagnosed with persistent pulmonary hypertension of the newborn

Scientists from the National Institutes of Health (NIH) Clinical Center and the Loma Linda University School of Medicine have found that use of an inhaled nitrite spray may help babies diagnosed with persistent pulmonary hypertension of the newborn (PPHN).

13 Sep 2004

Researchers look to make more effective drug treatments for tuberculosis

Tuberculosis isn’t yet making a major comeback in the U.S. but one- third of the world’s population is infected with the disease, and it poses a major danger to health worldwide.

26 Aug 2004

New class of compounds play a role in protecting the cardiovascular system

Half a million Americans are diagnosed each year with heart failure, a progressively debilitating condition characterized by the heart's declining ability to pump blood efficiently.

25 Aug 2004

Nitroxyl-releasing drugs promise to revive failing hearts

Half a million Americans are diagnosed each year with heart failure, a progressively debilitating condition characterized by the heart's declining ability to pump blood efficiently.

22 Aug 2004

Molecular biologists find chink in the armor of Candida, the most common human fungal pathogen

Molecular biologists at Rice University have discovered a key defense mechanism that the yeast Candida albicans uses against attack by the human immune system.

26 Jun 2004

African Americans suffer from cardiovascular diseases at a rate about five times higher than the rest of the U.S. population

African Americans suffer from cardiovascular diseases at a rate about five times higher than the rest of the U.S. population. In a new study, scientists may have found a culprit: a serious deficiency of nitric oxide, a small molecule vital in the regulation of blood flow and blood pressure.

11 Jun 2004

Genes that allow nerve cells to communicate may have come from bacteria eons ago

Some of the genes that allow nerve cells and some other types of cells to send elaborate chemical messages to each other appear to have been transferred to animals or their immediate ancestors from bacteria eons ago.

2 Jun 2004