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Researchers pinpoint genetic cause of Timothy syndrome

Howard Hughes Medical Institute researchers have pinpointed the genetic cause of a devastating but rare childhood disorder, called Timothy syndrome, which underlies a form of severe cardiac arrhythmia.

4 Oct 2004

Studies of human genetic variation have found strong evidence for the action of natural selection

One of the most comprehensive studies of the forces that have shaped patterns of human genetic variation has found strong evidence for the action of natural selection, which may help explain why certain people are at risk for a variety of conditions and others are not.

8 Sep 2004

New IBM technology could bring the promise of personalized medicine one step closer

Using a basic computer language, the researchers created a "smart" DNA stream that contains a patient's entire medical record

8 Sep 2004

Flaw in DNA helps explain cancers and aging

Their finding explains how oxidative DNA damage - a process long believed to underlie cancers and aging - can create permanent genetic damage.

30 Aug 2004

Finnish company discovers over 200 new genes

Finnish company Jurilab has announced the completion of a genome-wide scan in Acute Myocardial Infarction in the East Finland Founder Population.

12 Aug 2004

Personalised medicine designed to enhance people's chances of quitting smoking

The latest spin-out from the University of Oxford, G-Nostics, focuses on personalised medicine designed to enhance people's chances of quitting smoking.

6 Aug 2004

U.S. scientists have found the genetic basis for one form of sudden infant death syndrome

Sudden infant death syndrome, also known as cot death and crib death, is defined as the death of an infant between the ages of one month and one year which remains unexplained after a thorough postmortem, investigation of the death scene and review of the clinical history.

20 Jul 2004

First international server to analyze genetic diversity on a large scale

Researchers from the Universitat Autònoma de Barcelona have developed the first international server that allows the user to analyze genetic diversity on a large scale.

19 Jul 2004

Molecular mechanisms behind XsalF's anterior specifying activity

Embryologists have long been interested in working out the means by which this regionalization is achieved, and for years the dominant theory has involved a two-step mechanism in which neural tissues are first induced lengthwise down the entire body axis, followed by a transformation step where a second signal specifies the posterior identities of the neural tissue

13 Jul 2004

The structure of AGT shows how one human protein reduces the potency of chemotherapy

The fine details of this x-ray structure may help scientists find ways to fight certain cancers, such as brain tumors, which express high levels of AGT making them resistant to chemotherapy.

9 Jul 2004

Identification of a naturally occurring genetic difference that controls the production of serotonin in the brain

Researchers at Duke University Medical Center have provided the first direct evidence in mice for the role of an enzyme that specifically controls the production of serotonin in the brain.

8 Jul 2004

Chemoradioimmunotherapy for advanced breast cancer

A successful, and novel, technique to kill metastatic breast cancer cells by circumventing their chemo- and radioresistant mechanisms was by presented by Dr John Giannios, Head of Radiotherapeutic Cancer Research at the IASO Hospital

8 Jul 2004

Genes linked to cardiovascular disease more common among African Americans than those of European descent

Three gene variants that have been associated with heart attack risk in Japanese studies occur more frequently among African Americans than those of European descent

7 Jul 2004

Combining targeted immunotherapy with chemotherapy and radiation therapy to successfully kill metastatic tumour cells

A successful, and novel, technique to kill metastatic breast cancer cells by circumventing their chemo and radioresistant mechanisms was by presented by Dr. John Giannios, Head of Radiotherapeutic Cancer Research at the IASO Hospital

7 Jul 2004

How DNA repair machinery detects and corrects errors in DNA replication

Biochemists at Duke University Medical Center have discovered key components that enable the cell's DNA repair machinery to adeptly launch its action in either direction along a DNA strand to strip out faulty DNA.

2 Jul 2004

Genetic variation that doubles the risk for rheumatoid arthritis

A team of researchers has discovered a genetic variation that doubles the risk for rheumatoid arthritis (RA).

24 Jun 2004

Statins don't always lower cholesterol

Persons with certain genetic variations who take statins to lower their cholesterol will not realize the same benefit as other individuals, according to a study in the June 16 issue of the Journal of the American Medical Association (JAMA).

15 Jun 2004

Four critical components of cells' protein-building machine don't do what scientists had long assumed

In the hunt for these details, scientists have focused on four RNA building blocks, or nucleotides, deep within the machine that are identical in every species, from bacteria to humans. Because they sit where the protein chain is actually built, these "universally conserved" nucleotides in the ribosome were thought to help that process.

28 May 2004

Finding overturns long held ideas about how cells build proteins

Writing in the May 28 issue of Cell, Johns Hopkins researchers report that four critical components of cells' protein-building machine don't do what scientists had long assumed.

27 May 2004

International research team have decoded the genetic blueprint of the tularemia (rabbit fever) bacterium

Two teams of researchers, one based in the United States and the other in Europe, have decoded the genetic blueprint of the tularemia (rabbit fever) bacterium, a highly infectious human and animal pathogen.

6 May 2004