Nucleotide News and Research

RSS

The main source of editing of the mpox virus genome during the 2022 outbreak

Researchers investigated the main source of editing of the 2022 mpox virus genome.

11 Jan 2023

Genomic analysis of mpox virus genomes reveal multiple lineages with human-to-human transmissibility

Researchers from Nigeria and the United Kingdom (U.K.) analyzed mpox virus genomes and found that divergent lineages of the mpox virus exhibiting human-to-human transmission existed in the Nigerian population before the 2022 spread of the virus outside of the endemic regions.

10 Jan 2023

Researchers investigate Scandinavian history across 2,000 years

Researchers investigated the history of Scandinavia from the Roman period (between 1.0 CE and 400.0 CE) to the present, spanning over 2,000 years.

10 Jan 2023

Study shows XBB.1.5 exhibits a substantially higher hACE2-binding affinity compared to BQ.1.1 and XBB/XBB.1

Researchers investigated the reasons for the rapid advent of SARS-CoV-2 XBB.1.5, a sublineage of the Omicron recombinant mutant XBB in the USA.

6 Jan 2023

Horizontal gene transfer from mother to infant influences gut microbiome assembly, neurodevelopment, and immune maturation in infants

Researchers used a multi-omics approach to profile the gut microbiomes and metabolomes of mothers and infants to determine the vertical and horizontal transmission of bacterial species and strains as well as individual genes and understand the dynamics of the gut microbiome assembly that shape the development of the infant before and after birth.

29 Dec 2022

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

An enzyme that defends human cells against viruses can help drive cancer evolution towards greater malignancy by causing myriad mutations in cancer cells, according to a study led by investigators at Weill Cornell Medicine.

28 Dec 2022

Study shows de novo origination of functional microproteins

In a new study, researchers performed a genomic analysis to investigate the origination of human microproteins of biological importance.

23 Dec 2022

Mutations responsible for common inherited heart condition corrected using CRISPR-Cas9 therapy

Using the CRISPR-Cas9 gene editing system, UT Southwestern researchers corrected mutations responsible for a common inherited heart condition called dilated cardiomyopathy (DCM) in human cells and a mouse model of the disease.

21 Dec 2022

Immune-evading Mycobacterium tuberculosis prevents inflammatory responses by hijacking the host’s ubiquitin

A new study discussed the findings of Chai et al., which revealed that triple specificity protein phosphatase (ptpB) secreted by Mycobacterium tuberculosis inhibits pyroptosis and the release of cytokines by macrophages, allowing M. tuberculosis to invade the immune system.

19 Dec 2022

Polymorphisms in human immunoglobulin heavy chain genes can influence the function of SARS-CoV-2 neutralizing antibodies

Researchers isolated SARS-CoV-2 spike protein-targeted mAbs from convalescent healthcare workers, emphasizing the IGHV1-69 gene, the gene with the greatest structural and allelic variation.

14 Dec 2022

GOSH delivers world-first base-edited cell therapy for a patient with relapsed T cell leukemia

A patient with relapsed T cell leukemia has been given base-edited T-cells in a world-first use of a base-edited cell therapy, in a 'bench-to-bedside' collaboration between UCL and Great Ormond Street Hospital for Children (GOSH).

12 Dec 2022

Reports of Mpox disease following recent vaccination

The risk of infection and development of severe symptoms for Mpox remains, even after vaccination

11 Dec 2022

Better understanding of DNA repair mechanism may pave the way for effective cancer treatments

Better understanding of the mechanisms involved in DNA repair may pave the way for developing inhibitors to improve the effectiveness of radiation therapy.

9 Dec 2022

Mpox virus from Clade 2b is the least virulent strain according to new study

Researchers used the CAST/EiJ mouse model to test whether genetic differences between clades 1, 2a, and 2b of the monkeypox virus contribute to changes in transmission and virulence of the disease.

5 Dec 2022

How SARS-CoV-2 immune responses vary by population due to environmental and genetic factors

Researchers investigate the genetic, immunological, and evolutionary factors that determine the vast variability observed in clinical manifestations of COVID-19.

28 Nov 2022

Characterization of bat viromes reveals the co-infection, spillover, and emergence risk of several zoonotic viruses

Researchers characterized the mammal-infecting viruses in 149 bats, representing six genera and 15 species, sampled from Yunnan province, China using an unbiased meta-transcriptomics approach.

28 Nov 2022

BW.1- a new Omicron subvariant that escapes immunity

Researchers reports the presence of mutations that aid in immune escape in the BW.1 Omicron subvariant.

25 Nov 2022

Study shows clear shifts in SARS-CoV-2 mutational spectrum during evolution

Researchers examined whether the mutational process of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) itself has changed during the evolution of SARS-CoV-2.

23 Nov 2022

Diastolic blood pressure found to be associated with neuroticism

Diastolic blood pressure-;the lower of the two numbers in a blood pressure reading-;is highly likely to cause neurotic personality trait, finds research published in the open access journal General Psychiatry.

22 Nov 2022

Study suggests bats are an underrecognized arenavirus reservoir

Researchers reported the detection of arenavirus RNA from various species of bats sampled between 2007 and 2011 from Brazil.

21 Nov 2022