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Researchers investigate whole-genome data to uncover new mutations for CAD risk

The Coronary ARtery DIsease Genome-wide Replication And Meta-Analysis (CARDIoGRAM) published in Circulation Cardiovascular Genetics, an American Heart Association journal consists of data from every published whole-genome study on genetic mutations in heart attack or CAD risk. Researchers are also pooling data from several unpublished genome-wide association studies to see if any new mutations can be uncovered.

6 Oct 2010

New biomarkers could lead to personalized radiation treatments for cancer patients

Mayo Clinic researchers have discovered biomarkers that could lead to personalized radiation treatments for cancer patients. The findings appear today online in the journal Genome Research.

5 Oct 2010

New caproKits enable investigation of small molecule–protein interactions

caprotec bioanalytics GmbH announced today the commercial launch of three new caproKits, enabling the discovery, identification and characterization of proteins for applications in functional proteomics and drug development.

30 Sep 2010

Researchers find genetic variants that cause arthritis in breast cancer patients taking aromatase inhibitors

Mayo Clinic researchers and their international colleagues have discovered genetic variants that lead to severe arthritis for a subset of women when taking aromatase inhibitors to treat their breast cancer. This serious side effect is so painful that many women halt their lifesaving medication. The findings appear today in the online issue of Journal of Clinical Oncology.

28 Sep 2010

Researchers find no correlation between genetic ancestry and cancer stage

Head and neck cancer outcomes associated with race may be more closely linked to social and behavioral factors than biological differences, especially for African Americans, according to a new Henry Ford Hospital study.

27 Sep 2010

New study signals hope for treatment of rare neurodegenerative disease

A new study led by St. Jude Children's Research Hospital scientists signals hope for treatment of a neurodegenerative disease and a new model for understanding the mechanism at work in other more common neurodegenerative disorders.

23 Sep 2010

Genetic variation in taste pathway genes associated with dental caries risk

Dental caries is a highly prevalent disease that is disproportionately distributed in the population. Caries occurrence and progression is known to be influenced by a complex interplay of both environmental and genetic factors, with numerous contributing factors having been identified including bacterial flora, dietary habits, fluoride exposure, oral hygiene, salivary flow, salivary composition, and tooth structure. Previous reports have characterized the influence of the genetic variation on taste preferences and dietary habits.

23 Sep 2010

$Spanish researchers confirm genetic risk factor for osteoporosis and bone fractures$

Spanish researchers confirm genetic risk factor for osteoporosis and bone fractures

Spanish researchers have confirmed there is a genetic risk factor for osteoporosis and bone fractures. Although more studies are still needed, these findings will make it possible to take preventive measures.

22 Sep 2010

ASM awards UTHealth student 3-year, $33,000 fellowship for study of molecular details of protein folding in cells

Jennifer Abrams, a graduate student at The University of Texas Health Science Center at Houston (UTHealth), has been awarded a three-year, $33,000 fellowship from the American Society for Microbiology (ASM) to support her innovative research into the molecular causes of protein misfolding diseases like Alzheimer's, Lou Gehrig's and Parkinson's.

21 Sep 2010

BRCA1 gene mutation increases breast cancer risk: Research

Individuals with disrupting mutations in the BRCA1 gene are known to be at substantially increased risk of breast cancer throughout their lives. Now, discoveries from an international research team led by Mayo Clinic researchers show that some of those persons may possess additional genetic variants that modify their risk. These new findings enhancing individualized medicine appear in the current Nature Genetics.

20 Sep 2010

NHGRI announces fund to develop third generation DNA sequencing technologies

More than $18 million in grants to spur the development of a third generation of DNA sequencing technologies was announced today by the National Human Genome Research Institute (NHGRI). The new technologies will sequence a person's DNA quickly and cost-effectively so it routinely can be used by biomedical researchers and health care workers to improve the prevention, diagnosis and treatment of human disease.

14 Sep 2010

Good Start Genetics $18 million Series A financing round co-led by Safeguard Scientifics

Safeguard Scientifics, Inc., a holding company that builds value in growth-stage life sciences and technology companies, today announced that it has co-led a $18 million Series A financing round for Good Start Genetics, Inc. with OrbiMed Advisors, LLC and SV Life Sciences Advisers LLP.

10 Sep 2010

Helicos accuses PacBio of patent infringement, files lawsuit

Helicos BioSciences Corporation announced today that it has filed a lawsuit against Pacific Biosciences of California, Inc. for patent infringement. The lawsuit, filed in the United States District Court for the District of Delaware, accuses PacBio of infringing four patents and seeks injunctive relief and monetary damages.

9 Sep 2010

Complete Genomics, SAIC-Frederick collaborate to validate somatic mutations from pediatric cancer cases

Complete Genomics Inc., a life sciences company focused on human genome sequencing, today announced a collaboration to identify and validate somatic mutations from 50 pediatric cancer cases from multiple research centers across the United States.

7 Sep 2010

Idenix Pharmaceuticals receives clinical hold order from FDA for IDX184, IDX320 programs

Idenix Pharmaceuticals, Inc., a biopharmaceutical company engaged in the discovery and development of drugs for the treatment of human viral diseases, today announced that the company received verbal notice on Friday, September 3, 2010 from the U.S. Food and Drug Administration (FDA) that the IDX184 and IDX320 programs have been placed on clinical hold.

7 Sep 2010

Simple protocol for determining Gross Chromosomal Rearrangement mutation rates

A cell devotes a significant amount of effort to maintaining the stability of its genome, preventing the sorts of chromosomal rearrangements characteristic of many cancers. Assays that measure the rate of gross chromosomal rearrangements (GCRs) are needed in order to understand the individual genes and the different pathways that suppress genomic instability.

3 Sep 2010

GABRA2 gene influences brain’s reward responses to alcohol odors: Research

Single nucleotide polymorphisms (SNPs) are DNA sequence variations that occur when a single nucleotide in the genome sequence is altered. Prior research suggested an association between SNPs in a gene that encodes aspects of the brain's gamma-amino butyric acid (GABA)-A receptors (the GABRA2 gene) and alcohol dependence. A study of responses to the aromas of alcoholic drinks according to subjects' genotyping at a SNP in GABRA2 has found that this genotype can affect the brain's reward responses to cues such as alcohol odors.

3 Sep 2010

International consortium publishes third-generation map of human genetic variation

An international consortium today published a third-generation map of human genetic variation, called the HapMap, which includes data from an additional seven global populations, increasing the total number to 11 populations. The improved resolution will help researchers interpret current genome studies aimed at finding common and rarer genetic variants associated with complex diseases.

2 Sep 2010

Inhibitex completes INX-189 Phase1a trial for HCV

Inhibitex, Inc., announced today that it has successfully completed a Phase1a, first-in-man, single ascending dose trial of INX-189, its nucleotide polymerase inhibitor in development for the treatment of chronic hepatitis C (HCV) infections. In this trial, 42 healthy volunteers received either a single oral dose of INX-189, ranging from 3 mg to 100 mg, or placebo. The Company plans to present detailed results from this trial during a future scientific meeting.

2 Sep 2010

Genetic profiling to predict treatment benefits of ACE inhibitor therapy for CAD

The advantages of prescribing angiotensin-converting enzyme (ACE) inhibitors for stable coronary artery disease (CAD) may be increased by targeting the therapy to the patients most likely to benefit.Clinical characteristics alone do not allow a reliable identification of these patients, so a research programme was carried out at Erasmus University Medical Centre in Rotterdam to develop a genetic profiling model that predicts the treatment benefits of ACE inhibitors and optimises the recommended therapy.

31 Aug 2010

Nucleotide News and Research

Researchers investigate whole-genome data to uncover new mutations for CAD risk

New biomarkers could lead to personalized radiation treatments for cancer patients

New caproKits enable investigation of small molecule–protein interactions

Researchers find genetic variants that cause arthritis in breast cancer patients taking aromatase inhibitors

Researchers find no correlation between genetic ancestry and cancer stage

New study signals hope for treatment of rare neurodegenerative disease

Genetic variation in taste pathway genes associated with dental caries risk

Spanish researchers confirm genetic risk factor for osteoporosis and bone fractures

ASM awards UTHealth student 3-year, $33,000 fellowship for study of molecular details of protein folding in cells

BRCA1 gene mutation increases breast cancer risk: Research

NHGRI announces fund to develop third generation DNA sequencing technologies

Good Start Genetics $18 million Series A financing round co-led by Safeguard Scientifics

Helicos accuses PacBio of patent infringement, files lawsuit

Complete Genomics, SAIC-Frederick collaborate to validate somatic mutations from pediatric cancer cases

Idenix Pharmaceuticals receives clinical hold order from FDA for IDX184, IDX320 programs

Simple protocol for determining Gross Chromosomal Rearrangement mutation rates

GABRA2 gene influences brain’s reward responses to alcohol odors: Research

International consortium publishes third-generation map of human genetic variation

Inhibitex completes INX-189 Phase1a trial for HCV

Genetic profiling to predict treatment benefits of ACE inhibitor therapy for CAD

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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