Organic chemistry News and Research

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Scientists develop 3D-printable gelatin materials for reconstructive and plastic surgery

Researchers from IOCB Prague and Ghent University have been working on improving the properties of gelatin-based materials, thereby expanding the possibilities of their use mainly in medicine.

21 Feb 2024

New family of polymers can kill bacteria without inducing antibiotic resistance

Antibiotic-resistant bacteria have become a rapidly growing threat to public health. Each year, they account for more than 2.8 million infections, according to the U.S. Centers for Disease Control and Prevention.

22 Dec 2023

AI-powered "Coscientist" system designs and executes chemical reactions

In less time than it will take you to read this article, an artificial intelligence-driven system was able to autonomously learn about certain Nobel Prize-winning chemical reactions and design a successful laboratory procedure to make them.

20 Dec 2023

Natural compound activates macrophages to fight resistant tuberculosis bacteria

Tuberculosis (TB) is a prevalent infectious disease that affects millions of people each year. It was previously the leading cause of death from a single pathogen before the COVID-19 pandemic.

11 Dec 2023

New drug combination may improve treatment for rare nerve sheath tumors

Combining a pair of experimental drugs may help treat malignant peripheral nerve sheath tumors with fewer harmful side effects, according to preliminary animal studies led by investigators at the Johns Hopkins Kimmel Cancer Center and Johns Hopkins Drug Discovery.

1 Dec 2023

Amalus Therapeutics develops innovative approach for treating patients with cancer or fibrotic diseases

Ghent University and the booming Ghent biotech landscape welcome a brand new spin-off: Amalus Therapeutics is developing a new class of drugs that selectively target corrupt fibroblast cells.

20 Nov 2023

TUM start-up nominated for Science Breakthrough of the Year at Falling Walls summit

It all began with basic research: While conducting laboratory experiments, a team at the Technical University of Munich (TUM) came across an active agent against multidrug-resistant bacteria with a fundamental difference to antibiotics developed to date.

2 Nov 2023

Sulfate groups on complex sugar molecules affect brain plasticity

Can you recognize someone you haven't seen in years, but forget what you had for breakfast yesterday? Our brains constantly rearrange their circuitry to remember familiar faces or learn new skills, but the molecular basis of this process isn't well understood.

16 Aug 2023

New way to create unnatural amino acids identified

Every protein in your body is made up of the same 20 building blocks called amino acids. But just because nature is stuck with a limited toolkit doesn't mean humans can't expand it.

1 Aug 2023

Scientists discover a way to produce true structure of naturally-occurring anti-HIV compound

Having control over how a dish is cooked is always a good idea. Taking a hint from the kitchen, scientists appear to have discovered a way to produce a true structure of the rare but naturally-occurring anti-HIV compound Lancilactone C from start to finish.

28 Jul 2023

Fentanyl overdose reversal: New hope on the horizon

According to the Centers for Disease Control, 100,000 Americans die each year from an overdose, most due to the use of synthetic opiates like fentanyl. While naloxone, currently the only an antidote for opiate overdose, has become more common, it is less effective against fentanyl-class synthetic opioids.

18 Jul 2023

New method can track the complete activity of proteins in living cells

The genetic plans within our DNA come to functional fruition through proteins, which underlie our bodies' structure and activity.

29 Jun 2023

A new approach for the synthesis of pharmaceutically relevant fluorinated phenanthridines

Phenanthridines are heterocyclic compounds consisting of two six-membered benzene rings fused to a six-membered ring containing nitrogen.

26 Jun 2023

Structure of protein methyltransferase from the monkeypox virus deciphered

Scientists from the Institute of Organic Chemistry and Biochemistry in Prague have deciphered the structure of the protein methyltransferase from the monkeypox virus

30 Apr 2023

The Power of Solid-State Nuclear Magnetic Resonance in Biological Research

In this interview conducted at Pittcon 2023 in Philadelphia, Pennsylvania, we spoke to this year's recipient of the Pittsburgh Spectroscopy Award, Robert Tycko.

From Pittcon 20 Apr 2023

Scientific breakthrough by Sjöberg laureate brings new hope to lung cancer patients

This year's Sjöberg Prize in cancer research of one million dollars is awarded to professor Kevan Shokat, University of California, USA.

15 Feb 2023

Study finds high levels of hydrogen peroxide in pancreatic cancer cells

Reactive oxygen species (ROS) are reputed for their involvement in carcinogenesis. Results from a study published in the journal Angewandte Chemie have now shown that the level of one such ROS,

7 Feb 2023

Simple technique could be a powerful solution for disposing ‘forever chemicals’

PFAS, a group of manufactured chemicals commonly used since the 1940s, are called "forever chemicals" for a reason.

18 Aug 2022

Acid ceramidase is a SARS-CoV-2 host factor, study says

Fluoxetine, a common antidepressant, inhibits the SARS-CoV-2 coronavirus in cell cultures and in preparations from human lung tissue. This was demonstrated by researchers at Julius-Maximilians-Universität (JMU) Würzburg in the summer of 2020. However, the mechanism of this inhibition was utterly unclear, so the teams continued their research.

17 Aug 2022

New method can modify an entire substance class of medically relevant natural products

The use of the element fluorine to modify active substances is an important tool in modern drug development.

5 Aug 2022