Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

Human colon organoids fill gap in effectively modeling common GI diseases

Scientists used human pluripotent stem cells to generate human embryonic colons in a laboratory that function much like natural human tissues when transplanted into mice, according to research published June 22 in Cell Stem Cell.

22 Jun 2017

Researchers bioengineer human liver tissues that mimic natural development

An international team of researchers bioengineering human liver tissues uncovered previously unknown networks of genetic-molecular crosstalk that control the organ's developmental processes – greatly advancing efforts to generate healthy and usable human liver tissue from human pluripotent stem cells.

15 Jun 2017

Developing synthetic mediums for growing organoids

Organoids are bits of tissue grown in vitro, in a near-physiological 3D setting. The particularity consists in the fact that organoids retain features of the patient they are derived from, even when cultured outside of the human body. This is very different from what traditional, conventional cell culture has been able to do over the past 50 years or so.

13 Jun 2017

Researchers receive federal funding to study consequences of West Nile and Zika virus infections

A Georgia State University researcher, in collaboration with researchers at the University of Pennsylvania and Florida State University, has received a five-year, $7.7 million federal grant to study the consequences of West Nile and Zika virus infections on the human central nervous system.

2 Jun 2017

New method combines organoid technology with bioengineering to build better brains

A few years ago, Jürgen Knoblich and his team at the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) have pioneered brain organoid technology. They developed a method for cultivating three-dimensional brain-like structures, so called cerebral organoids, in a dish.

1 Jun 2017

CUMC researchers create new organoids that mimic features of full-sized lung

New lung "organoids"-tiny 3-D structures that mimic features of a full-sized lung- have been created from human pluripotent stem cells by researchers at Columbia University Medical Center. The team used the organoids to generate models of human lung diseases in a lab dish, which could be used to advance our understanding of a variety of respiratory diseases.

11 May 2017

New organoid ‘fusion’ technique helps observe complex interactions between diverse brain regions

In 2013 researchers led by IMBA scientist Jürgen Knoblich flabbergasted the scientific community. Starting from human stem cells, researchers in his lab managed to grow living three dimensional models of basic units of human brain in a dish.

11 May 2017

Scientists grow and purify earliest lung progenitors from human stem cells

Human lungs, like all organs, begin their existence as clumps of undifferentiated stem cells. But in a matter of months, the cells get organized. They gather together, branch and bud, some forming airways and others alveoli, the delicate sacs where our bodies exchange oxygen for carbon dioxide.

3 May 2017

IU researchers develop new method to grow inner ear tissue from human stem cells

Researchers at Indiana University School of Medicine have successfully developed a method to grow inner ear tissue from human stem cells-; PhDa finding that could lead to new platforms to model disease and new therapies for the treatment of hearing and balance disorders.

3 May 2017

Gene critical for tumor progression also encourages growth of intestinal stem cells, study shows

A gene previously identified as critical for tumor growth in many human cancers also maintains intestinal stem cells and encourages the growth of cells that support them, according to results of a study led by Johns Hopkins researchers.

28 Apr 2017

NETRF announces $4 million in collaborative grants to study neuroendocrine tumors

The Neuroendocrine Tumor Research Foundation today announced its largest research commitment ever -- $4 million in collaborative grants -- most from its new Accelerator Grants program to study neuroendocrine tumors, a widely misunderstood, commonly misdiagnosed cancer type, without adequately identified genomic drivers.

27 Apr 2017

KU Leuven researchers grow three-dimensional cultures of the uterus' inner lining in a dish

Scientists at KU Leuven, Belgium, have succeeded in growing three-dimensional cultures of the endometrium, the uterus' inner lining, in a dish.

25 Apr 2017

Scientists grow womb lining models that could shed light on early pregnancy events

Scientists from the University of Cambridge have grown miniature functional models of the womb lining in culture, representing a major step forwards in the study of early-stage pregnancy and conditions such as endometriosis.

11 Apr 2017

Miniature models of ‘womb lining’ could provide insights into early pregnancy and menstrual cycle

Scientists at the University of Cambridge have succeeded in growing miniature functional models of the lining of the womb (uterus) in culture.

10 Apr 2017

Organoids in cell culture dish offer new insights into development of the brain

A new method could push research into developmental brain disorders an important step forward. This is shown by a recent study at the University of Bonn in which the researchers investigated the development of a rare congenital brain defect.

4 Apr 2017

Researchers suggest potential new way to restore healthy intestinal function in older people

Intestinal stem cells rejuvenate daily so bowels will stay healthy and function normally, but a new study in Cell Reports suggests they also age along with people and lose their regenerative capacity.

15 Mar 2017

Scientists gain new insight into early brain pathology of schizophrenia using adult skin cells

The skin cells of four adults with schizophrenia have provided an unprecedented "window" into how the disease began while they were still in the womb, according to a recent paper in Schizophrenia Research.

27 Feb 2017

X-ray helps identify atomic composition of micronutrients in human brain organoids

Micronutrients and minerals play a key role during human fetal development. A study published in PeerJ this week describes the composition and distribution of some elements in human minibrains created in the lab.

13 Feb 2017

Scientists use brain organoids to identify root causes of Miller-Dieker syndrome

Research led by scientists at UC San Francisco and Case Western Reserve University School of Medicine has used brain "organoids" — tiny 3D models of human organs that scientists grow in a dish to study disease — to identify root causes of Miller-Dieker Syndrome (MDS), a rare genetic disorder that causes fatal brain malformations.

7 Feb 2017

HUB and Dutch health insurance companies to test use of organoid technology for CF treatment

Hubrecht Organoid Technology (HUB), and the health insurance companies CZ, Zilveren Kruis, and Menzis announced today that they will start a €3 million validation trial for use of HUB Organoid Technology to test if it can be used to determine the response of Cystic Fibrosis (CF) patients to new drug therapies.

9 Jan 2017