Osteosarcoma News and Research

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Between two and three percent of all childhood cancers are osteosarcoma. Because osteosarcoma usually develops from osteoblasts, it most commonly affects children and young adults experiencing their adolescent growth spurt. Boys and girls have a similar incidence rate until later in their adolescence, when boys are more commonly affected. While most tumors occur in larger bones, such as the femur, tibia, and humerus, and in the area of the bone that has the fastest growth rate, they can occur in any bone. The most common symptom is pain, but swelling and limited movement can occur as the tumor grows.

Osteosarcoma is an orphan disease with approximately 1,200 new cases diagnosed in the United States each year. A similar incidence of the disease exists in Europe. According to the Children's Oncology Group (COG), the survival of children with osteosarcoma has remained at 60-65 percent since the mid-1980s. The standard treatment for osteosarcoma is tumor resection with combination chemotherapy before and after surgery.
Research identifies unique vulnerabilities in ALT cancers that can serve as novel therapeutic targets

Research identifies unique vulnerabilities in ALT cancers that can serve as novel therapeutic targets

Inhaled recombinant IL-15 tested in pet dogs with metastatic lung disease from osteosarcoma or melanoma

Inhaled recombinant IL-15 tested in pet dogs with metastatic lung disease from osteosarcoma or melanoma

Scientists identify the role of phospholipid in maintaining epithelial cellular adhesion

Scientists identify the role of phospholipid in maintaining epithelial cellular adhesion

Soy molasses and kudzu roots may help fight against pediatric tumors

Soy molasses and kudzu roots may help fight against pediatric tumors

TTUHSC researcher secures $1.9 million grant to investigate vulnerabilities in ALT cancers

TTUHSC researcher secures $1.9 million grant to investigate vulnerabilities in ALT cancers

Study links phthalates to higher incidence of specific childhood cancers

Study links phthalates to higher incidence of specific childhood cancers

Zentalis contributes $1 million to SU2C Catalyst program for research into targeted cancer therapeutics

Zentalis contributes $1 million to SU2C Catalyst program for research into targeted cancer therapeutics

Penn Medicine receives $12.3 million NIH grant to study FLASH radiotherapy for cancer

Penn Medicine receives $12.3 million NIH grant to study FLASH radiotherapy for cancer

Antibody combination produces a synergistic response in difficult-to-treat pediatric cancers

Antibody combination produces a synergistic response in difficult-to-treat pediatric cancers

The antiviral function of BET protein against SARS-CoV-2 infection

The antiviral function of BET protein against SARS-CoV-2 infection

SARS-CoV-2 B.1.617 mutations L452 and E484Q do not work together to evade antibodies

SARS-CoV-2 B.1.617 mutations L452 and E484Q do not work together to evade antibodies

Specialized protein appears to regulate key step in cancer metastasis

Specialized protein appears to regulate key step in cancer metastasis

Combination of SFRP2 and PD-1 immunotherapy halts aggressive metastatic cancer in preclinical model

Combination of SFRP2 and PD-1 immunotherapy halts aggressive metastatic cancer in preclinical model

New potential target for treating metastasized oral malignant melanoma in dogs

New potential target for treating metastasized oral malignant melanoma in dogs

Cognitive outcomes in survivors of childhood cancers have been largely understudied

Cognitive outcomes in survivors of childhood cancers have been largely understudied

New technology shows encouraging results for treating osteosarcoma

New technology shows encouraging results for treating osteosarcoma

$11 million COBRE funding will help create Center for Pre-Clinical Cancer Research at LSU SVM

$11 million COBRE funding will help create Center for Pre-Clinical Cancer Research at LSU SVM

ALSF announces grant award recipients of Crazy 8 Initiative in pediatric oncology

ALSF announces grant award recipients of Crazy 8 Initiative in pediatric oncology

Study reveals how cells build 'mini-muscles' underneath their nucleus

Study reveals how cells build 'mini-muscles' underneath their nucleus

Study outlines the reasons to test pediatric cancer patients for inherited genes

Study outlines the reasons to test pediatric cancer patients for inherited genes