Osteosarcoma News and Research

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Between two and three percent of all childhood cancers are osteosarcoma. Because osteosarcoma usually develops from osteoblasts, it most commonly affects children and young adults experiencing their adolescent growth spurt. Boys and girls have a similar incidence rate until later in their adolescence, when boys are more commonly affected. While most tumors occur in larger bones, such as the femur, tibia, and humerus, and in the area of the bone that has the fastest growth rate, they can occur in any bone. The most common symptom is pain, but swelling and limited movement can occur as the tumor grows.

Osteosarcoma is an orphan disease with approximately 1,200 new cases diagnosed in the United States each year. A similar incidence of the disease exists in Europe. According to the Children's Oncology Group (COG), the survival of children with osteosarcoma has remained at 60-65 percent since the mid-1980s. The standard treatment for osteosarcoma is tumor resection with combination chemotherapy before and after surgery.
Study uncovers complicated role of simple protein in spread of osteosarcoma

Study uncovers complicated role of simple protein in spread of osteosarcoma

Fennec presents positive interim results from phase III trial of sodium thiosulphate at ASCO 2015

Fennec presents positive interim results from phase III trial of sodium thiosulphate at ASCO 2015

FDA clears ADXS-HPV plus epacadostat IND for HPV-associated cervical cancer Phase 2 study

FDA clears ADXS-HPV plus epacadostat IND for HPV-associated cervical cancer Phase 2 study

New genetic models allow for comprehensive analysis of drivers for osteosarcoma

New genetic models allow for comprehensive analysis of drivers for osteosarcoma

Stem cell disease model reveals how tumor suppressor may drive bone cancer

Stem cell disease model reveals how tumor suppressor may drive bone cancer

Researchers pinpoint molecular mechanisms that inhibit Hippo pathway in pediatric bone cancers

Researchers pinpoint molecular mechanisms that inhibit Hippo pathway in pediatric bone cancers

Shire announces availability of Natpara (parathyroid hormone) for injection in U.S.

Shire announces availability of Natpara (parathyroid hormone) for injection in U.S.

CPRIT awards research and recruitment grants to improve cancer research

CPRIT awards research and recruitment grants to improve cancer research

Study details a new pathway for tumor formation

Study details a new pathway for tumor formation

New cancer drug enters phase I clinical trials in humans

New cancer drug enters phase I clinical trials in humans

Clinical study data of Advaxis' Lm-LLO immunotherapies to be presented at SITC Annual Meeting

Clinical study data of Advaxis' Lm-LLO immunotherapies to be presented at SITC Annual Meeting

Newly-identified cancer cell fingerprints in the blood could help diagnose childhood cancer

Newly-identified cancer cell fingerprints in the blood could help diagnose childhood cancer

Dominica Anderson named recipient of 2014 Julie and Ben Rogers Award for Excellence in Patient Care

Dominica Anderson named recipient of 2014 Julie and Ben Rogers Award for Excellence in Patient Care

Researchers study effect of alcohol on neural activity using fruit flies

Researchers study effect of alcohol on neural activity using fruit flies

Researchers investigate distribution of trace elements in tissue of bone tumours

Researchers investigate distribution of trace elements in tissue of bone tumours

Experimental antibody temporarily halts progression of neuroblastoma in children

Experimental antibody temporarily halts progression of neuroblastoma in children

Tumor-suppressing protein acts as dimmer switch to dial down gene expression

Tumor-suppressing protein acts as dimmer switch to dial down gene expression

Alteration in tumor suppressor gene TP53 plays key role early in development of bone cancer

Alteration in tumor suppressor gene TP53 plays key role early in development of bone cancer

ChromaTrap™ Chromatin Immunoprecipitation technology receives positive commentary in published paper

ChromaTrap™ Chromatin Immunoprecipitation technology receives positive commentary in published paper

First patient dosed in ADXS-HPV Phase 1/2 study for HPV-associated head and neck cancer

First patient dosed in ADXS-HPV Phase 1/2 study for HPV-associated head and neck cancer