Paclitaxel News and Research

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Paclitaxel is a drug used to treat breast cancer, ovarian cancer, and AIDS-related Kaposi sarcoma. It is also used together with another drug to treat non-small cell lung cancer. Paclitaxel is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division and may kill cancer cells. It is a type of antimitotic agent. Also called Taxol.

The Paclitaxel compound is extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). Check for active clinical trials or closed clinical trials using this agent.

Scientists use novel technology for opening blood-brain barrier with implantable ultrasound

One of most potent drugs for treatment of glioblastoma, the most deadly type of brain tumor, can't be used in patients because of two problems. First, it can't reach its target because it's blocked by the blood-brain barrier, a microscopic structure that protects the brain from toxins in the blood. And the conventional formulation for this drug is toxic to the brain.

12 Dec 2019

New drug combo promises help for triple negative breast cancer patients

A new preclinical study on triple negative breast cancer (TNBC) reports that an experimental polo-like kinase 1 (PLK1) inhibitor shrank tumor four times more powerfully when used along with standard drugs than alone. The study, reported in the journal PLOS ONE, opens up a new door of opportunity for patients with this disease.

11 Dec 2019

Combination regimen shows promising results in preclinical models of triple negative breast cancer

Tumor volume in a preclinical model of triple negative breast cancer (TNBC) was reduced four times more when an experimental polo-like kinase 1 (PLK1) inhibitor was combined with a standard-of-care chemotherapeutic agent than when the agent was used alone.

10 Dec 2019

Medicinal plants: from genes to drugs

We eat plants, wear their products, burn them for fuel, and use them to build our houses. Plants are the very basis of the food chain on earth. They are also the source of oxygen in the atmosphere, and a treasure house containing a host of compounds that have biological effects on the body. Some of these chemicals are produced as self-defence, to guard against pests and diseases.

27 Nov 2019

Regulating gut bacteria could calm chemo side effects, reduce cognitive problems

In a new study, scientists observed several simultaneous reactions in mice given a common chemotherapy drug: Their gut bacteria and tissue changed, their blood and brains showed signs of inflammation, and their behaviors suggested they were fatigued and cognitively impaired.

11 Nov 2019

Atlantic Health System Cancer Care enrolling patients in five pancreatic cancer studies

November is National Pancreatic Cancer Awareness month. This year alone, more than 56,000 Americans will be diagnosed with pancreatic cancer. Pancreatic tumors are particularly aggressive and hard to treat "due to a mutational profile that makes it resistant to therapies that work better for other tumor types," explains Angela Alistar, MD, medical director of GI Oncology at Morristown Medical Center.

30 Oct 2019

NCCN ORP plans to support phase II randomized trial for lung cancer patients

The National Comprehensive Cancer Network Oncology Research Program today announced plans to support a phase II randomized trial for lung cancer patients.

28 Oct 2019

Researchers discover new chemical weapon to fight against cancer

The fight against cancer involves eradicating cancer cells but current treatments inevitably have negative consequences on healthy cells.

23 Oct 2019

Newly discovered organelle could help prevent cancer

Scientists at the University of Virginia School of Medicine have discovered a strange new organelle inside our cells that helps to prevent cancer by ensuring that genetic material is sorted correctly as cells divide.

22 Oct 2019

Oncolytics Biotech and PrECOG collaborate to study metastatic breast cancer

Oncolytics Biotech Inc. , currently developing pelareorep, an intravenously delivered immuno-oncolytic virus, and PrECOG LLC, a leading cancer research network, today announced their collaboration in which PrECOG will run the BRACELET-1 (PrE0113) study.

22 Oct 2019

Paclitaxel-coated devices used for widening blocked arteries not linked to increased mortality

Devices coated with a drug called paclitaxel that are used for widening blocked arteries in legs and feet are safe and not linked to an increase in deaths, according to a study of nearly 65,000 patients, published in the European Heart Journal today (Wednesday).

9 Oct 2019

Study on gene mutations may lead to better diagnosis and treatment for cancer

When a cell divides into two daughter cells, it must replicate its DNA according to a very specific scenario. In the presence of some disruptive elements, however, cancer cells are unable to perform this operation optimally; replication then takes place more slowly and less efficiently.

25 Sep 2019

Study links FAK protein to chemotherapy resistance in ovarian cancer

Although the number of women being diagnosed and dying of ovarian cancer is declining, recurrence, drug resistance and mortality remain high for women with high-grade serous ovarian carcinoma, the most common form of epithelial ovarian cancer.

3 Sep 2019

Nab-Paclitaxel drug combo reduces risk of breast cancer recurrence

A recent large German study has shown that a new combination therapy for breast cancer treatment leads to a lowered risk of the disease coming back. A commentary on this landmark clinical trial has been published in the latest issue of the Journal of Clinical Oncology by the researchers Masey Ross and Charles Geyer Jr. from the VCU Massey Cancer Center. The commentary was titled, “Nab-Paclitaxel: A New Standard of Care in Neoadjuvant Therapy of High-Risk Early Breast Cancer?”

27 Aug 2019

Researchers demonstrate the effectiveness of new bladder cancer treatment

Researchers from the Molecular Cancer group at the Hospital del Mar Medical Research Institute and doctors from Hospital del Mar, have demonstrated the effectiveness of a drug for treating metastatic bladder cancer in patients who did not respond to the usual treatment.

27 Aug 2019

SU2C Dream Team to develop new drug combination to stop spread of breast cancer

At a press conference at McGill University today, Stand Up To Cancer Canada, the Canadian Cancer Society, and the Canadian Institutes of Health Research announced the launch of the SU2C Canada Metastatic Breast Cancer Dream Team to pursue the development of a new drug combination that may help stop the spread of breast cancer to other organs of the body.

13 Aug 2019

Paclitaxel News and Research

Further Reading

Scientists use novel technology for opening blood-brain barrier with implantable ultrasound

New drug combo promises help for triple negative breast cancer patients

Combination regimen shows promising results in preclinical models of triple negative breast cancer

Medicinal plants: from genes to drugs

Regulating gut bacteria could calm chemo side effects, reduce cognitive problems

Atlantic Health System Cancer Care enrolling patients in five pancreatic cancer studies

NCCN ORP plans to support phase II randomized trial for lung cancer patients

Researchers discover new chemical weapon to fight against cancer

Newly discovered organelle could help prevent cancer

Oncolytics Biotech and PrECOG collaborate to study metastatic breast cancer

Paclitaxel-coated devices used for widening blocked arteries not linked to increased mortality

Study on gene mutations may lead to better diagnosis and treatment for cancer

Study links FAK protein to chemotherapy resistance in ovarian cancer

Nab-Paclitaxel drug combo reduces risk of breast cancer recurrence

Researchers demonstrate the effectiveness of new bladder cancer treatment

SU2C Dream Team to develop new drug combination to stop spread of breast cancer

Longer-lived, but less toxic drug may work better for pancreatic cancer

New drug-delivery system disguises chemotherapeutics as fat to outsmart tumors

New drug combinations and dosing schedules improve outlook in advanced colon cancer

Processed aconite root could relieve neuropathic pain in murine peripheral neuropathy

One Health, One Mission: The World Organisation for Animal Health on the AMR Frontline

Uniting Against Resistance: The World Health Organization for World Antimicrobial Awareness Week 2023

Tackling Antimicrobial Resistance: A Conversation with Dr. Beverley Isherwood

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