Pancreas News and Research

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The pancreas is a gland organ in the digestive and endocrine system of vertebrates. It is both an endocrine gland producing several important hormones, including insulin, glucagon, and somatostatin, as well as an exocrine gland, secreting pancreatic juice containing digestive enzymes that pass to the small intestine. These enzymes help in the further breakdown of the carbohydrates, protein, and fat in the chyme.

Oral-gut axis: How mouth bacteria impact your overall health

A recent review in Nature Reviews Microbiology highlights how oral and gut microbiomes interact, impacting overall human health. Oral microorganisms can enter the gut, contributing to dysbiosis and various diseases, necessitating further research on these complex interactions.

24 Jul 2024

Type 1 diabetes in children linked to increased risk of mental health problems

Children diagnosed with type 1 diabetes are at significantly higher risk of a number of mental health issues, including mood and anxiety disorders, a study from a team in the UK and the Czech Republic has found.

18 Jul 2024

Researchers find a special group of "first responder" cells crucial for triggering blood sugar response

How does our body control blood sugar so precisely? An international research team led by scientists from the Paul Langerhans Institute Dresden (PLID) of the German Center for Diabetes Research brought us a step closer to the answer.

17 Jul 2024

AGA releases new clinical guidance to help recognize the symptoms of cyclic vomiting syndrome

The American Gastroenterological Association (AGA) has released new clinical guidance to help clinicians and patients recognize the signs and symptoms of cyclic vomiting syndrome (CVS).

16 Jul 2024

Researchers discover a new mechanism of resistance to KRAS inhibitors in pancreas cancer

Mutations in the KRAS gene are the primary driver of pancreatic cancer. A new class of drugs known as KRAS inhibitors is showing initial promise in clinical trials, but many tumors quickly develop resistance to the treatment.

11 Jul 2024

Distinct T-cell signatures identified in children with type 1 diabetes

A study conducted at the University of Eastern Finland found distinct signatures in CD8-positive T cells in blood samples from children with newly diagnosed type 1 diabetes and in autoantibody-positive children who later developed type 1 diabetes.

11 Jul 2024

Stanford researchers uncover key to overcoming chemoresistance in pancreatic cancer

Pancreatic cancer is a particularly aggressive and difficult-to-treat cancer, in part because it is often resistant to chemotherapy.

4 Jul 2024

Fibrinogen-like protein 1 plays dual role in liver regeneration and hepatocellular carcinoma recurrence

Hepatocellular carcinoma (HCC), a leading cause of cancer-related mortality globally, exhibits a dismal five-year survival rate of only 18%.

2 Jul 2024

Regulatory T cells exist as large, mobile population that travels through body to repair damaged tissue

Researchers investigated populations of regulatory T cells, a type of white blood cell, in various tissues.

1 Jul 2024

Natural compound found in olives can lower blood sugar levels and promote weight loss

Findings from a new mouse study suggest that elenolic acid, a natural compound found in olives, can lower blood sugar levels and promote weight loss.

29 Jun 2024

Study provides resource for investigating diabetes-linked transcription factors

Scientists have generated a comprehensive map of the gene targets regulated by the transcription factors HNF4A and HNF1A in human pancreatic beta cells and liver cells. Published in the journal Nature Communications, the study revealed common and tissue-specific molecular pathways regulated by HNF4A and HNF1A, two proteins that possess important functions governing the development and function of the pancreas and liver.

26 Jun 2024

MicroRNAs shed light on aggressive youthful type 2 diabetes

Type 2 diabetes in young people ages 10 to19 has more than doubled in the past 20 years, yet it remains difficult for physicians to predict who will be diagnosed and who will improve with treatment. A newly published study from the University of Oklahoma shows that measuring the circulating abundance of microRNAs – which affect insulin-producing beta cells in the pancreas – is likely as effective as measuring the level of sugar in the blood for determining how a young person with the condition will fare.

25 Jun 2024

Research points to a potential approach to mitigating diabetes risk from antipsychotic medications

New University of Pittsburgh research points to a potential approach to reducing the risk of diabetes associated with widely prescribed antipsychotic medications.

13 Jun 2024

Innovative FAP-targeted radioligand therapy controls disease progression in sarcoma

Fibroblast activation protein (FAP)-targeted radioligand therapy is safe and effective for treating patients with progressive metastatic tumors, specifically advanced sarcomas, according to research presented at the 2024 Society of Nuclear Medicine and Molecular Imaging Annual Meeting.

10 Jun 2024

How increased mTOR activity shortens lifespan and promotes aging-related diseases

The reality of a population who is aging at an accelerated rate makes it a priority to understand what happens in the body over time, on a molecular scale.

7 Jun 2024

New antioxidant biomaterial may provide relief to people living with chronic pancreatitis

Northwestern University researchers have developed a new antioxidant biomaterial that someday could provide much-needed relief to people living with chronic pancreatitis.

7 Jun 2024

Novel PET radiotracer enables same-day imaging of gastrointestinal cancer biomarker

A new PET radiotracer enables same-day imaging of the important gastrointestinal cancer biomarker known as Claudin18.2 (CLDN18.2).

6 Jun 2024

Oral insulin drops offer needle-free alternative for diabetes management

Diabetes rates continue to rise, with 11.7 million Canadians living with diabetes or pre-diabetes. At UBC, scientists have created a pain-free drug delivery method to help people with diabetes manage the disease and maintain their health more easily.

5 Jun 2024

GLP-1 drugs may reduce pancreatitis risk in obese and diabetic patients

Medications for type 2 diabetes and obesity known as GLP-1 receptor agonists may lower the risk of acute pancreatitis recurrence in people with obesity and those with type 2 diabetes, according to a study presented Saturday at ENDO 2024, the Endocrine Society's annual meeting in Boston, Mass.

3 Jun 2024

Experimental treatment for metastatic pancreatic cancer shows promise in phase 2 clinical trial

Clinicians at Georgetown University's Lombardi Comprehensive Cancer Center reported promising preliminary findings based on outcomes in the first six patients with metastatic pancreatic cancer enrolled in a phase 2 clinical trial of the experimental drug BXCL701 in combination with the immunotherapy drug pembrolizumab (Keytruda).