Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

New gene editing method creates first mice with human-like COVID-19

Researchers have genetically engineered the first mice that get a human-like form of COVID-19, according to a study published online November 1 in Nature.

1 Nov 2023

Metabolic increase in the hippocampus is early sign of Alzheimer's disease, study finds

An early phase in the process of developing Alzheimer's disease is a metabolic increase in a part of the brain called the hippocampus, report researchers from Karolinska Institutet in a study published in Molecular Psychiatry.

31 Oct 2023

Speeding up Alzheimer's research: Progerin turbocharges cellular models for quicker drug screening

The study reveals that introducing progerin, a protein associated with accelerated aging, into cellular models of Alzheimer's Disease (AD) can hasten the development of AD-related traits. This innovative approach offers a more efficient method for studying AD mechanisms, potentially accelerating the discovery of new treatments.

31 Oct 2023

A four-stage classification of heart attack based on heart muscle damage

Heart attacks, or acute myocardial infarction (MI), are one of the leading causes of death worldwide. The newly released Canadian Cardiovascular Society Classification of Acute Myocardial Infarction (CCS-AMI) appearing in the Canadian Journal of Cardiology, published by Elsevier, presents a four-stage classification of heart attack based on heart muscle damage.

31 Oct 2023

Unbiased proteomic analysis reveals fibroinflammatory landscape of the aging ovary

A new priority research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 20, entitled, "Proteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature."

31 Oct 2023

Brain autopsy study of intimate partner violence victims shows extensive brain damage

The largest brain autopsy study of women who had experienced intimate partner violence reveals substantial vascular and white matter damage in the brain, but no evidence of chronic traumatic encephalopathy (CTE), the neurodegenerative disease recognized among male contact sports athletes who sustain repeated head trauma.

30 Oct 2023

Research reveals both protective and harmful gut microbiota associated with sleep apnea risk

The causal relationship between gut microbiota, associated metabolites, and obstructive sleep apnea (OSA).

30 Oct 2023

Redefining the battle against Alzheimer's with tau-focused treatments

Researchers explore the potential of tau-targeting therapies in treating Alzheimer's disease, focusing on immunotherapies and strategies to improve their efficacy. The study dives into the complex biology of tau proteins, their modifications, and how they can be targeted to halt the progression of Alzheimer's.

29 Oct 2023

Is sleep apnea the missing link between high blood pressure and Alzheimer's?

Researchers explore the links between non-dipper hypertension, obstructive sleep apnea (OSA), and Alzheimer's disease (AD). They find that OSA may cause non-dipper hypertension, a condition that exacerbates AD symptoms, but also note that treating OSA can mitigate hypertension and potentially slow AD progression.

29 Oct 2023

Loss of structural protein ACTL7B blocks spermatogenesis in male mice

Mature spermatozoa are characterized by an head, midpiece and a long tail for locomotion. Now, researchers from the University Hospital Bonn (UKB) and the Transdisciplinary Research Unit "Life & Health" at the University of Bonn have found that a loss of the structural protein ACTL7B blocks spermatogenesis in male mice.

27 Oct 2023

IU researchers play key roles in national consortium to study the use of Alzheimer's disease biomarkers

Researchers at Indiana University School of Medicine will play key roles in a national consortium led by Wake Forest University School of Medicine to study the use, interpretation and implementation of biomarkers to diagnose Alzheimer's disease.

27 Oct 2023

Single-cell proteomics – when mass spectrometry revolutionizes biomedical research

In the latest episode of the OMG Omx podcast, Bruker's Kate Stumpo talks to Nikolai Slavov about the incredible potential of mass spectrometry proteomics in biomedical research.

From Bruker Life Sciences Mass Spectrometry 27 Oct 2023

Doubts abound about a new Alzheimer’s blood test

For the first time, people worried about their risk of Alzheimer's disease can go online, order a blood test, and receive results in the privacy of their homes.

26 Oct 2023

Boosting brain health with iron and manganese: A dietary defense against cognitive decline

The recent study published in Nutrients explores the link between dietary mineral intake and cognitive impairment in elderly Spanish individuals, finding that increased consumption of iron and manganese significantly reduced cognitive impairment risk in women but showed no effect in men.

25 Oct 2023

New AI model aims to fix flaws in smartphone-based COVID-19 X-ray diagnosis

Researchers highlight the limitations and challenges of using AI models for diagnosing COVID-19 from chest X-rays shared via smartphones. The study introduces a new multi-task learning model to improve diagnostic accuracy, addressing issues like prediction instability and faulty focus areas in images.

25 Oct 2023

Neoadjuvant pembrolizumab achieves major pathologic response in more than half of patients with resectable melanoma

In exploratory analyses of results from the SWOG S1801 trial in patients with stage III-IV resectable melanoma, researchers saw a major pathologic response in more than half of surgical specimens taken from patients who had been treated with neoadjuvant (pre-operative) pembrolizumab.

24 Oct 2023

Study sheds light on role of gut fungi in severe COVID-19 and long COVID

Certain gut-dwelling fungi flourish in severe cases of COVID-19, amplifying the excessive inflammation that drives this disease while also causing long-lasting changes in the immune system, according to a new study led by investigators at Weill Cornell Medicine and NewYork-Presbyterian.

24 Oct 2023

Study reveals an alternate origin of brain mosaicism in some children with focal epilepsy

In most people, every cell in their body contains the same genetic information. However, sometimes people can have two or more genetically different sets of cells.

24 Oct 2023

Is COVID-19 a risk factor for Alzheimer's disease?

The study explores the interconnected risks between COVID-19 and Alzheimer's Disease (AD), highlighting how SARS-CoV-2 can aggravate AD pathology through neuroinflammation and neurodegeneration. It raises significant concerns about the long-term cognitive implications of COVID-19, especially among those already at risk for AD.

23 Oct 2023

Can strawberries mitigate Alzheimer's risk? Recent study suggests a possibility

Whether strawberry supplementation mitigates the risk for late-life dementia.

23 Oct 2023

Pathology News and Research

Further Reading

New gene editing method creates first mice with human-like COVID-19

Metabolic increase in the hippocampus is early sign of Alzheimer's disease, study finds

Speeding up Alzheimer's research: Progerin turbocharges cellular models for quicker drug screening

A four-stage classification of heart attack based on heart muscle damage

Unbiased proteomic analysis reveals fibroinflammatory landscape of the aging ovary

Brain autopsy study of intimate partner violence victims shows extensive brain damage

Research reveals both protective and harmful gut microbiota associated with sleep apnea risk

Redefining the battle against Alzheimer's with tau-focused treatments

Is sleep apnea the missing link between high blood pressure and Alzheimer's?

Loss of structural protein ACTL7B blocks spermatogenesis in male mice

IU researchers play key roles in national consortium to study the use of Alzheimer's disease biomarkers

Single-cell proteomics – when mass spectrometry revolutionizes biomedical research

Doubts abound about a new Alzheimer’s blood test

Boosting brain health with iron and manganese: A dietary defense against cognitive decline

New AI model aims to fix flaws in smartphone-based COVID-19 X-ray diagnosis

Neoadjuvant pembrolizumab achieves major pathologic response in more than half of patients with resectable melanoma

Study sheds light on role of gut fungi in severe COVID-19 and long COVID

Study reveals an alternate origin of brain mosaicism in some children with focal epilepsy

Is COVID-19 a risk factor for Alzheimer's disease?

Can strawberries mitigate Alzheimer's risk? Recent study suggests a possibility

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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