Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Addiction – a brain disorder say experts

According to the American Society of Addiction Medicine, addiction is a chronic brain disorder like any other chronic brain disease such as obsessive-compulsive disorder and body dysmorphic disorder. Neurological abnormalities like disruptions in neurotransmission and the reward system drive addiction, the group said in a statement.

17 Aug 2011

U-M's epilepsy surgery could successfully treat patients with seizures

John Ligerakis was told he had to learn to live with seizures that had made it challenging for him to work or drive a car. A young professional just starting his career, Ligerakis was devastated about what his future might bring.

17 Aug 2011

Methodist, Philips partner to develop new imaging technology for infectious diseases

The Methodist Hospital Research Institute and Philips Healthcare are collaborating to develop new imaging technology that could be used to help identify the start -- and cause -- of an infectious disease epidemic.

From Philips Healthcare 17 Aug 2011

Seattle Children's receives Gates Foundation grant to complete development of Sea-PAP

Seattle Children's Research Institute today announced the receipt of a two-year, $2.3 million grant from the Bill & Melinda Gates Foundation to complete prototype development of its new respiratory support device, called Seattle Children's Positive Airway Pressure.

17 Aug 2011

Drug SLM3 prevents multiplication of tumor cells

Tumors that do not respond to chemotherapy are the target of a cancer therapy that prevents the function of two enzymes in mouse tumor cells, according to Pennsylvania medical researchers.

17 Aug 2011

Flexible-fiber CO2 laser-assisted ablation safe for endoscopic assisted transsphenoidal craniotomies

A new study has shown the Flexible-Fiber CO2 laser to safely cut and coagulate during endoscopic assisted transsphenoidal craniotomies (TSC) without the line of sight problems encountered with conventional CO2 lasers.

17 Aug 2011

Gene therapy cocktail can treat inherited diseases with 'misfolded' proteins

In a kind of molecular gymnastics, scientists at the University of North Carolina at Chapel Hill School of Medicine have devised a gene therapy cocktail that has the potential to treat some inherited diseases associated with "misfolded" proteins.

16 Aug 2011

Researchers identify oncoprotein that allows MCV virus to trigger Merkel Cell Carcinoma

Researchers at the University of Pittsburgh Cancer Institute (UPCI) have identified the oncoprotein that allows a common and usually harmless virus to transform healthy cells into a rare but deadly skin cancer called Merkel Cell Carcinoma.

16 Aug 2011

G-CSF therapy does not induce chromosomal instability in healthy stem cell donors

According to a study published in Blood, the Journal of the American Society of Hematology (ASH), researchers have reported that administration of granulocyte colony-stimulating factor (G-CSF), a drug that releases stem cells from the bone marrow into the blood, is unlikely to put healthy stem cell donors at risk for later development of abnormalities involving loss or gains of chromosomes that have been linked to hematologic disorders such as myelodysplastic syndromes (MDS) and acute myeloid leukemia.

12 Aug 2011

MYCN amplification can serve as a favorable prognostic indicator for neuroblastoma

Neuroblastoma, a malignant tumor that primarily affects infants and young children, is a leading cause of death for children with cancer. When amplification of the MYCN oncogene is found in the tumor, it usually indicates an aggressive tumor with rapid progression of the disease and a poor outcome. Thus MYCN amplification has come to be used as a prognostic indicator.

12 Aug 2011

Researchers identify novel sensory pathway that modulates pro-inflammatory cells

New research led by Derya Unutmaz, MD associate professor, the Departments of Pathology, Medicine, and Microbiology at NYU School of Medicine and Mark Sundrud, PhD, of Tempero Pharmaceuticals, Inc., has identified a novel sensory pathway that modulates the potency of Th17 cell responses.

11 Aug 2011

Cancer-causing fusion protein works by silencing tumor suppressor gene IL-2Rγ

Mariusz A. Wasik, MD, professor of Pathology and Laboratory Medicine, and Qian Zhang, MD, PhD, research assistant professor, both from the Perelman School of Medicine at the University of Pennsylvania, and their colleagues, found that a cancer-causing fusion protein works by silencing the tumor suppressor gene IL-2R common gamma-chain.

10 Aug 2011

Researchers clarify role of two proteins key to T-cell development

In the latest issue of Nature, researchers at the Perelman School of Medicine at the University of Pennsylvania clarify the role of two proteins key to T-cell development.

9 Aug 2011

Engineered T cells can eradicate deadly human ovarian cancer in immune-deficient mice

In a recent issue of Cancer Research, Daniel J. Powell, Jr., PhD, a research assistant professor of Pathology and Laboratory Medicine and Obstetrics and Gynecology at the Perelman School of Medicine at the University of Pennsylvania, showed for the first time that engineered human T cells can eradicate deadly human ovarian cancer in immune-deficient mice.

9 Aug 2011

Region Skåne selects LABVANTAGE for digitizing histopathological workflows

Region Skåne, has selected LABVANTAGE to deliver a $4 million turn-key solution for digitizing the histopathological workflows of the whole region. The system will possibly be the largest such installation in the world and among the first in northern Europe.

8 Aug 2011

Leica Microsystems, CMED partner to co-develop and market automated FISH kits

China Medical Technologies, Inc. (CMED), a leading China-based advanced in-vitro diagnostic ("IVD") company, and Leica Biosystems, a division of Leica Microsystems, a world leader in microscopes and scientific instruments, today announced that they have established a sales, research and development collaboration to co-develop and market automated FISH kits to be used on the Leica BOND system.

8 Aug 2011

New insights into cancer-induced intussusceptive angiogenesis

Researchers have gained a new understanding of the way in which growing tumors are fed and how this growth can be slowed via angiogenesis inhibitors that eliminate the blood supply to tumors. This represents a step forward towards developing new anti-cancer drug therapies.

8 Aug 2011

Metallofullerene platform holds promise for treatment of brain tumors

A single compound with dual function - the ability to deliver a diagnostic and therapeutic agent - may one day be used to enhance the diagnosis, imaging and treatment of brain tumors, according to findings from Virginia Commonwealth University and Virginia Tech.

5 Aug 2011

Scientists convert human skin cells into forebrain neurons

Columbia University Medical Center researchers have for the first time directly converted human skin cells into functional forebrain neurons, without the need for stem cells of any kind.

5 Aug 2011

RNAi screen identifies Brd4 as a therapeutic target for acute myeloid leukemia

Scientists at Cold Spring Harbor Laboratory (CSHL) and five other institutions have used an unconventional approach to cancer drug discovery to identify a new potential treatment for acute myeloid leukemia.

4 Aug 2011

Pathology News and Research

Further Reading

Addiction – a brain disorder say experts

U-M's epilepsy surgery could successfully treat patients with seizures

Methodist, Philips partner to develop new imaging technology for infectious diseases

Seattle Children's receives Gates Foundation grant to complete development of Sea-PAP

Drug SLM3 prevents multiplication of tumor cells

Flexible-fiber CO2 laser-assisted ablation safe for endoscopic assisted transsphenoidal craniotomies

Gene therapy cocktail can treat inherited diseases with 'misfolded' proteins

Researchers identify oncoprotein that allows MCV virus to trigger Merkel Cell Carcinoma

G-CSF therapy does not induce chromosomal instability in healthy stem cell donors

MYCN amplification can serve as a favorable prognostic indicator for neuroblastoma

Researchers identify novel sensory pathway that modulates pro-inflammatory cells

Cancer-causing fusion protein works by silencing tumor suppressor gene IL-2Rγ

Researchers clarify role of two proteins key to T-cell development

Engineered T cells can eradicate deadly human ovarian cancer in immune-deficient mice

Region Skåne selects LABVANTAGE for digitizing histopathological workflows

Leica Microsystems, CMED partner to co-develop and market automated FISH kits

New insights into cancer-induced intussusceptive angiogenesis

Metallofullerene platform holds promise for treatment of brain tumors

Scientists convert human skin cells into forebrain neurons

RNAi screen identifies Brd4 as a therapeutic target for acute myeloid leukemia

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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