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Copper transporter plays an unexpected role in the absorption of cisplatin

Platinum complexes such as the well-known cisplatin are powerful antitumor medications. They cross the cell membrane and reach the nucleus, where they attach to DNA and stop cell growth. But how does cisplatin get to the nucleus?

30 Oct 2007

Discovery of new peptide communication factor in bacteria

Discovery by Hebrew University of Jerusalem researchers of a new communication factor that enables bacteria to "talk to each other" and causes their death could have significant consequences leading to development of a new class of antibiotic medications.

29 Oct 2007

Hairpin-shaped mimetics imitate the helical protein that plays a role in the spread of HIV

When a host cell is infected with HIV, the virus brings its own genetic material into the host cell. This cell then replicates, reads the viral RNA, and uses it as a blueprint to produce more viral proteins.

29 Oct 2007

Emerging cancer therapies and novel targets

What are the cancer drugs of tomorrow and how will they be developed? At the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, researchers will present some answers to these and other pressing questions regarding emerging cancer therapeutics.

25 Oct 2007

New imaging technique ensures rapid profiling of autoantibodies in rheumatoid arthritis

Using a new imaging technique, a fast and accurate profile of autoantibodies present in the blood serum of rheumatic patients can be made.

25 Oct 2007

New method of oral insulin delivery patented

Syracuse University researchers have designed, tested and patented a new method of oral insulin delivery that can potentially help reduce daily insulin injections for millions of people with diabetes who require therapy for optimal glycemic control.

22 Oct 2007

Ubiquitin builds up an immune response

Ubiquitin is a small protein, which can be attached to other cellular proteins, a process known as ubiquitination.

22 Oct 2007

New active compound for the treatment of malaria

Malaria is caused by Plasmodium parasites and it is the female Anopheles mosquito that acts as a vector for these malarial parasites in to the human body.

16 Oct 2007

Important insights into blood vessel formation

Researchers have identified a molecular pathway that plays a critical role in the growth of blood vessels.

15 Oct 2007

Discovery of way to match pathogens to their antibodies

The search for a vaccination against HIV has been in progress since 1984, with very little success.

15 Oct 2007

How does the opioid system work?

The opioid system controls pain, reward and addictive behaviors. Opioids exert their pharmacological actions through three opioid receptors, mu, delta and kappa whose genes have been cloned (Oprm, Oprd1 and Oprk1, respectively).

15 Oct 2007

Scientists identify brain circuits that 'decide' how much we eat

Scientists have identified the brain circuits that 'decide' how much we eat. Using live brain scanning techniques and an innovative study design, researchers have discovered how the brain controls food intake in humans. Their findings are published in Nature.

15 Oct 2007

Study unravels some of the mystery surrounding the devastating 1918 pandemic

Often called the most devastating epidemic in the recorded history of the world, the 1918 influenza virus pandemic was responsible for more than 40 million deaths across the globe.

10 Oct 2007

Brookhaven's D-peptides halt HIV entry into cells

Based in part on protein structures determined at the National Synchrotron Light Source (NSLS) at the U.S. Department of Energy's Brookhaven National Laboratory, scientists at the University of Utah have developed new peptides that appear to be significantly more effective at blocking HIV's entry into cells than other drugs in their class.

10 Oct 2007

Bacteria reveal targets of immune responses quick and direct identification of antigens

The Epstein-Barr virus (EBV) is a widespread herpes virus that infects more than 90 per cent of the worldwide human population.

10 Oct 2007

Tiny radioactive molecules provide novel way to fight colorectal cancer

Johns Hopkins scientists have developed a potentially novel way to fight colorectal cancer using tiny molecules to deliver potent barrages of radiation inside cancer cells, unlike current treatments that bind to the surface of cells and attack from the outside and cause unwanted side effects.

10 Oct 2007

New peptides inhibit HIV's entry into cells

9 Oct 2007

Researchers create modular, multi-functional drug delivery system

There are two aspects to creating an effective drug: finding a chemical compound that has the desired biological effect and minimal side-effects and then delivering it to the right place in the body for it to do its job.

8 Oct 2007

What our genes tell us - Identifying biomarkers for key environmental risk factors

Identifying biomarkers for the key environmental risk factors responsible for two diseases that significantly contribute to death and disease of hundreds of thousands annually will be the initial focus of a new center being established at Pacific Northwest National Laboratory.

4 Oct 2007

Linking two molecular pieces may offer new approaches to treating Alzheimer's disease

Researchers have uncovered a biological link between the protein whose mutation causes early-onset Alzheimer's disease (AD) and a gene variant linked to late-onset AD.

4 Oct 2007