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NogoReceptor reduces Alzheimer's plaque

Increasing the level of a protein that plays a key role in traumatic spinal cord injuries and multiple sclerosis reduces the concentration of disease-causing plaque in Alzheimer's disease, Yale School of Medicine researchers report in the Journal of Neuroscience.

12 Feb 2006

Hormone discovered in bird brains also plays major role in mammalian reproductive system

University of California, Berkeley, researchers have discovered a new actor in the mammalian reproductive system, a hormone that fills a role long suspected, but until now undetected.

7 Feb 2006

Intracellular observation of RNA metabolism will help identify disease-associated RNAs

For the first time, researchers can now peer inside intact cells to not only identify RNA-binding proteins, but also observe-in real-time-the intricate activities of these special molecules that make them key players in managing some of the cell's most basic functions.

7 Feb 2006

Breakthrough in lupus research

A major breakthrough in lupus research - one that may fundamentally change thinking on how the disease affects behavior and cognition - was reported in the January 17, 2006 Proceedings of the National Academy of Sciences (PNAS).

25 Jan 2006

Compounds in blackcurrants could prevent Alzheimer's disease

Compounds in blackcurrants could prevent Alzheimer's disease and the characteristics of British berries suggest they do it best, writes Jennifer Rohn in Chemistry & Industry magazine.

18 Jan 2006

Protein finding could lead to new topical treatment for inflammatory diseases

A protein that undesirably shields a skin poxvirus from the immune system may become the key ingredient in a new topical treatment for inflammatory diseases, say medical researchers at the University of Illinois at Urbana-Champaign.

11 Jan 2006

Gene that increases risk for Alzheimer's disease

An international team of researchers, led by investigators at Washington University School of Medicine in St. Louis, are zeroing in on a gene that increases risk for Alzheimer's disease. They have identified a region of chromosome 10 that appears to be involved in risk for the disease that currently affects an estimated 4.5 million Americans.

10 Jan 2006

p11 gene may play a key role in depression

For the more than 18 million Americans who suffer from depressive illnesses, the best pharmacological treatments are those that increase levels of serotonin, the brain chemical that regulates mood, sleep and memory.

5 Jan 2006

Researchers discover how a gene linked to Parkinson’s disease can keep brain cells alive

Researchers at the University of Colorado at Denver and Health Sciences Center’s School of Medicine have uncovered how a gene linked to Parkinson’s disease can keep brain cells alive. The results suggest the possibility for new drugs that might regulate the gene and protect Parkinson’s patients from further cell damage.

29 Dec 2005

Controlled delivery of peptide nanofibers for myocardial protection

Reminiscent of the 1966 sci-fi thriller Fantastic Voyage, where a surgical team is miniaturized and injected into a dying man, researchers from Harvard Medical School have used injectable self-assembling peptide nanofibers loaded with the pro-survival factor PDGF-BB to protect rat cardiomyocytes from injury and subsequent heart failure.

15 Dec 2005

Anti-Abeta42 and Anti-Abeta40–specific monoclonal antibodies attenuate amyloid deposition in an Alzheimer disease mouse model

Current hypotheses suggest that it is the accumulation over time of amyloid beta peptide 1–42 (Abeta42) that triggers changes in the brain that lead to cognitive dysfunction in Alzheimer's disease.

13 Dec 2005

GRK2 protein - potential drug target for heart failure

A protein that plays an important regulatory role in heart failure in the heart also exerts powerful effects on the adrenal gland, Jefferson Medical College researchers have found. The protein, GRK2, is a potential drug target for heart failure.

28 Nov 2005

Fear gene discovered

In the Nov. 18 issue of Cell, researchers report the discovery of a gene that controls the ability to react with appropriate fear to impending danger.

26 Nov 2005

Persistent amyloidosis following suppression of Ab production in a transgenic model of Alzheimer disease

Alzheimer Disease (AD) is characterized by hallmark lesions called amyloid plaques in the brain.

20 Nov 2005

Genetically modified allow scientists to examine the potential usefulness of new therapies for Alzheimer's disease

Researchers with the University of Florida and the California Institute of Technology have developed a new strain of genetically modified mice that allow scientists to examine the potential usefulness of new therapies for Alzheimer's disease.

20 Nov 2005

Molecular origins of diabetes

An unexpected twist to a discovery reported just two months ago may significantly improve our understanding about the molecular origins of diabetes.

14 Nov 2005

First clinical study of FX06 treatment against damage caused by heart attacks

Central to the study is FXO6, a peptide developed and patented by Austro-American company Fibrex Medical. Fibrex will now test the tolerability and pharmacokinetics of FX06 in humans. The peptide reduces inflammatory responses of the heart muscle that can arise after treatment for a myocardial infarction. Tests will begin immediately on the first - healthy - subjects at the Vienna General Hospital.

7 Nov 2005

Resveratrol effective in lowering amyloid-beta peptides

A study published in the November 11 issue of the Journal of Biological Chemistry shows that resveratrol, a compound found in grapes and red wine, lowers the levels of the amyloid-beta peptides which cause the telltale senile plaques of Alzheimer's disease.

7 Nov 2005

New high-resolution data on intact ribosome

A new, sharper picture of the nano-machine that translates our genetic program into proteins promises to help researchers explain how some types of antibiotics work and could lead to the design of better ones.

7 Nov 2005

New targeted cancer drug delivery system

Prostate, breast and other cancer patients may be offered a new, stauncher targeted drug delivery system to treat their diseases in the next decade.

3 Nov 2005

Peptides News and Research

NogoReceptor reduces Alzheimer's plaque

Hormone discovered in bird brains also plays major role in mammalian reproductive system

Intracellular observation of RNA metabolism will help identify disease-associated RNAs

Breakthrough in lupus research

Compounds in blackcurrants could prevent Alzheimer's disease

Protein finding could lead to new topical treatment for inflammatory diseases

Gene that increases risk for Alzheimer's disease

p11 gene may play a key role in depression

Researchers discover how a gene linked to Parkinson’s disease can keep brain cells alive

Controlled delivery of peptide nanofibers for myocardial protection

Anti-Abeta42 and Anti-Abeta40–specific monoclonal antibodies attenuate amyloid deposition in an Alzheimer disease mouse model

GRK2 protein - potential drug target for heart failure

Fear gene discovered

Persistent amyloidosis following suppression of Ab production in a transgenic model of Alzheimer disease

Genetically modified allow scientists to examine the potential usefulness of new therapies for Alzheimer's disease

Molecular origins of diabetes

First clinical study of FX06 treatment against damage caused by heart attacks

Resveratrol effective in lowering amyloid-beta peptides

New high-resolution data on intact ribosome

New targeted cancer drug delivery system

Exploring the intersection of biology and proteomics

Unlocking the Secrets of Multiple Sclerosis Progression: Brain-Immune Cell Communication

Passing on Polycystic Ovary Syndrome: Health risks for male offspring of women with PCOS

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