Pharmacokinetics News and Research

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The term pharmacokinetics is derived from the ancient Greek words “pharmakon” and “kinetikos”, meaning “drug” and “putting in motion” respectively. It is one of the main branches of pharmacology, and refers to the way that the body reacts on and affects a pharmaceutical substance in the body.

Promising candidate medication for preventing and reversing fentanyl-induced overdose

Researchers assessed CSX-1004, a monoclonal antibody (mAb), for its efficacy in reversing fentanyl overdose based on its high affinity for fentanyl, positive animal model results, and safe pharmacokinetic profile, positioning it as a potential solution in the opioid crisis.

7 Dec 2023

Nanotechnology could enhance traditional Chinese medicine delivery, promising improved clinical outcomes

This review in the Journal of Nanobiotechnology explores how nanotechnology enhances the delivery of traditional Chinese medicines (TCMs), overcoming challenges like poor solubility and limited bioavailability. Nanocarriers like liposomes and nanoparticles improve TCM delivery, offering greater therapeutic effectiveness and reduced side effects, but face challenges in biocompatibility and stability for clinical use.

30 Nov 2023

Pomegranate's power: Studies show promise in cardiovascular and diabetic health

Researchers reviewed existing data on the bio-modulatory effects of pomegranate (Punica granatum l., PG) polyphenols on metabolic disorders.

24 Nov 2023

Oral antibiotic taken once-daily for six months reduces risk of developing drug-resistant TB

Two landmark clinical trials reported today at the Union meeting showed that an oral antibiotic taken for six months once-daily substantially reduced the risk of developing drug-resistant TB.

16 Nov 2023

Breakthrough study: inhibiting USP30 gene offers hope in treating Parkinson’s disease

Whether USP30 inhibition can serve as a disease-modifying therapy for Parkinson's disease (PD).

15 Nov 2023

Neural circuits respond to rapid dopamine surges

Researchers assess the pharmacodynamics of dopamine signaling, brain connectivity/activity, and self-documented 'high' following methylphenidate exposure.v

14 Nov 2023

Revolutionizing critical care: the potential of gut microbiota therapeutics

The curative potential and limitations of gut microbiome-based therapeutics in critical illnesses.

13 Nov 2023

Pharmacogenomics holds promise for personalized dementia therapies

Pharmacogenomics-based studies in the research for personalized therapeutics for dementia

8 Nov 2023

Shifting towards personalized treatment approaches for chronic inflammatory diseases

Chronic inflammatory diseases affect 5% to 7% of the population, regardless of age or sex, from children to the elderly.

6 Nov 2023

Clinical trial demonstrates the effectiveness of ALS drug in treating people with acute spinal cord injuries

A small clinical trial with a pharmacokinetic sub-study, led by a world-renowned pharmacologist at the University of Houston, has demonstrated the promising effectiveness of the drug Riluzole for improving functionality in people with acute spinal cord injuries (SCI) if the drug is taken within 12 hours post-injury.

1 Nov 2023

Day-to-day painkiller use doesn't lower empathy levels, but misuse might, according to recent survey

The association between low empathy and prosocial behavior on the one hand and analgesic consumption.

30 Oct 2023

Can your diet soda habit affect your baby? New study explores low-calorie sweeteners in breastmilk

U.S. scientists are studying if low-calorie sweeteners like sucralose and acesulfame-potassium can be transferred from mothers to infants through breastfeeding. This first-of-its-kind pharmacokinetic model aims to understand the health implications of early-life exposure to these sweeteners.

26 Oct 2023

Red grape polyphenol, resveratrol: a multifaceted therapeutic powerhouse under review

The therapeutic potential of resveratrol, a red grape polyphenol.

25 Oct 2023

Insilico Medicine to present scientific data on novel anti-cancer assets at major cancer conferences

Clinical stage artificial intelligence (AI) drug discovery company Insilico Medicine ("Insilico") has been invited to present scientific data on its novel anti-cancer assets at three major upcoming cancer conferences -- the European Society for Medical Oncology (ESMO) conference in Madrid Oct. 20-24, 2023; the Society of Immunotherapy of Cancer (SITC) conference Nov. 1-5, 2023 in San Diego; and the San Antonio Breast Cancer Symposium (SABCS) Dec. 5-9, 2023.

16 Oct 2023

Can herbal remedies, spices, and dietary fibers offer effective treatment options for children with irritable bowel syndrome (IBS)?

The positive effects and adverse reactions of spices, dietary fiber, and medicinal herbs for pediatric patients with IBS.

16 Oct 2023

New TB treatments tackle the disease without wrecking your microbiome

Researchers in a study published in The Lancet Microbe examined how various tuberculosis treatment regimens affect the respiratory microbiome. They found that certain treatments control tuberculosis effectively while minimally impacting the diversity and health of the respiratory microbiome.

15 Oct 2023

Intracellular journey: The penetration of antidepressants into cells, organelles, and membranes

Researchers in neuropsychopharmacology challenge conventional wisdom about antidepressants' actions, revealing significant intracellular activity that influences their effectiveness. Utilizing advanced technologies, the study prompts a reevaluation of drug targeting and mechanisms, opening new avenues for treating depression.

12 Oct 2023

Does your gut microbiome play a role in therapeutic outcomes?

The role of the gut microbiome and its metabolites in altering the therapeutic outcomes

12 Oct 2023

Exploring the link between drugs and microbiota: a growing imperative in precision medicine

The intricate interactions between gut microbiota and drugs.

11 Oct 2023

Gut health and leukemia: Exploring the crucial connection between diet and microbiota changes

Gut microbiota's role in leukemia treatment responses is explored, with evidence suggesting diet and prebiotics may help manage microbiota alterations in patients. Diet during pregnancy, breastfeeding, and gut microbiota composition all intersect, potentially influencing leukemia risks and treatment outcomes.

8 Oct 2023