Pharmacokinetics News and Research

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The term pharmacokinetics is derived from the ancient Greek words “pharmakon” and “kinetikos”, meaning “drug” and “putting in motion” respectively. It is one of the main branches of pharmacology, and refers to the way that the body reacts on and affects a pharmaceutical substance in the body.

Rice University leads development of innovative bioelectronic implant for obesity and diabetes

Rice University is part of a multiuniversity research team that has secured an award of up to $34.9 million from the Advanced Research Projects Agency for Health (ARPA-H) to accelerate the development of a bioelectronic implant designed to improve adherence for obesity and type 2 diabetes (T2D) treatment while reducing development and manufacturing costs.

3 Oct 2024

How can microdialysis benefit drug development?

In this interview, discover how Charles River uses the power of microdialysis for drug development as well as CNS therapeutics.

From Charles Rivers Laboratories Neuroscience 3 Sep 2024

Researchers develop four new regimens to treat people with multidrug-resistant TB meningitis

In a preliminary study with a small number of humans, rabbits and mice, researchers at Johns Hopkins Children's Center say they have developed four new regimens that have the potential to treat and save the lives of people with multidrug-resistant (MDR) tuberculous (TB) meningitis.

16 Aug 2024

New insights into the pharmacokinetics of remdesivir in treating SARS-CoV-2 in pregnant women

A new study provides important insights into the pharmacokinetics and safety of intravenous remdesivir in treating the SARS-CoV-2 coronavirus in pregnant women.

13 Aug 2024

New review highlights advances in diabetes research and treatment

A new paper surveying advances in diabetes pathogenesis and treatment explores the complex factors contributing to the onset and progression of the disease, suggesting that an understanding of these dynamics is key to developing targeted interventions to reduce the risk of developing diabetes and managing its complications.

25 Jul 2024

Safety-focused summary of GLP-1 receptor agonists in diabetes, obesity, and beyond

A recent review in Diabetes Care evaluates the efficacy and safety of GLP-1 receptor agonists for type 2 diabetes and obesity, exploring their potential for new medical indications.

18 Jun 2024

Tailoring polymeric micelles for improved olaparib solubility and drug release

Olaparib is a selective poly (ADP-ribose) polymerase inhibitor. However, its clinical application is hindered by low solubility and undesired pharmacokinetic profiles (e.g., relatively short circulation).

23 May 2024

New drug-like molecules show promise in preventing influenza by blocking virus entry

Currently available flu medications only target the virus after it has already established an infection, but what if a drug could prevent infection in the first place?

21 May 2024

New PET imaging agent shows promise in visualizing lesions in clear cell renal cell cancer patients

A novel investigational PET imaging agent can rapidly and accurately visualize lesions in clear cell renal cell cancer (ccRCC) patients according to new research published in the May issue of The Journal of Nuclear Medicine.

7 May 2024

Gyros Protein Technologies introduces Gyrolab Generic Rodent ADA Kit Reagents to support preclinical immunogenicity assessment

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From Gyros Protein Technologies AB 3 May 2024

New system personalizes chemotherapy doses for cancer patients

When cancer patients undergo chemotherapy, the dose of most drugs is calculated based on the patient's body surface area. This is estimated by plugging the patient's height and weight into an equation, dating to 1916, that was formulated from data on just nine patients.

24 Apr 2024

Breakthrough imaging method enhances precision in prostate cancer treatment

A novel SPECT/CT acquisition method can accurately detect radiopharmaceutical biodistribution in a convenient manner for prostate cancer patients, opening the door for more personalized treatment.

17 Apr 2024

Insilico Medicine's AI-driven approach yields promising PTPN2/N1 inhibitor for cancer immunotherapy

In recent years, cancer immunotherapy, exemplified by PD-1 and its ligand PD-L1 blockade, has made remarkable advances.

13 Apr 2024

UC researchers open Phase 2 clinical trial to test new combination treatment for glioblastomas

A multidisciplinary team of University of Cincinnati Cancer Center researchers have opened a Phase 2 clinical trial to test a new combination treatment for glioblastomas (GBM), the most deadly form of brain tumors.

26 Mar 2024

Rising antimicrobial resistance in STIs: A call for global action

Review delves into the rising challenge of antimicrobial resistance in sexually transmitted infections, underscoring the need for innovative treatments and the critical role of global surveillance in managing diseases like gonorrhea and syphilis.

21 Mar 2024

Aston University and Catalent develop faster medicine formulation process

A partnership between Aston University and contract medicine manufacturer Catalent has led to a faster process to identify the best ingredients for optimal medicine formulations, and has been rated as outstanding by Innovate UK.

19 Mar 2024

Nanoparticles turbocharge turmeric's curcumin for enhanced health benefits

Study explores nanoparticle-enhanced curcumin formulations, promising to significantly boost its health benefits including anticancer, antioxidant, and anti-inflammatory effects by improving bioavailability and bioactivity.

17 Mar 2024

New hope for binge eating and bulimia: GLP-1 drugs could be the key

GLP-1 receptor agonists show promise in reducing binge eating behaviors in disorders like bulimia nervosa, offering a new avenue for treatment with minimal side effects.

4 Mar 2024

Research validates concurrent use of HIV medications and gender-affirming hormone therapy

New research definitively shows that HIV antiretrovirals can be taken together with gender-affirming hormone therapy without changing how well either drug works.