Phenotype News and Research

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RPS-12 protein overproduction appears to trigger breast cancer and other malignancies

Using the developing eye of the fruit fly as a test platform, researchers found that RPS-12 protein overproduction appears to trigger triple-negative breast cancer and possibly some other malignancies.

29 Jan 2021

Researchers explore adaptive immunity against human coronaviruses

A recent study shows that long-term adaptive immunity to endemic coronaviruses is widespread, but low in magnitude, and that it shares phenotypic features of spike-specific antibodies and T cell memory across all tested coronaviruses.

29 Jan 2021

Study finds protective genetic associations with mild COVID-19

Using self-reported survey data, researchers have defined eight phenotypes associated with COVID-19 outcomes. Analysis of the data revealed possible protective genetic associations.

29 Jan 2021

Genomic studies give new insights into the biological basis of PTSD

After analyzing the genomes of more than one-quarter of a million military veterans, a team of scientists, led by researchers at University of California San Diego, Veterans Affairs San Diego Healthcare System (VASDHS), Yale University and West Haven VA, have identified 18 specific, fixed positions on chromosomes (known as loci) that appear associated with post-traumatic stress disorder (PTSD).

28 Jan 2021

New compound may slow aging and age-related diseases

A compound that extends lifespan in a tiny nematode worm slows bone loss in aging mice. That surprising result comes from a longitudinal and functional study of 700 aging mice at the Buck Institute, a project that provides a treasure trove of data for researchers aiming to develop therapeutics to slow aging and age-related diseases.

27 Jan 2021

Study shows why children of obese mothers have propensity to develop metabolic diseases

A Brazilian study published in the journal Molecular Human Reproduction helps understand why obese mothers tend to have children with a propensity to develop metabolic disease during their lifetime, as suggested by previous research.

26 Jan 2021

Circulating antiphospholipid antibodies drive endothelial cell activation in COVID-19

With the emergence of COVID-19 (coronavirus disease 2019), researchers have been closely investigating the complex interplay between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the human immune system, and COVID-19 disease severity.

25 Jan 2021

Reduced expression of TBX15 in tumor tissue represents a prognostic biomarker for HCC patients

The cover for issue 52 of Oncotarget features Figure 1, "Volcano plots of DNA methylation in tumor tissues compared with nontumor tissue," published in "Reduction of T-Box 15 gene expression in tumor tissue is a prognostic biomarker for patients with hepatocellular carcinoma" by Morine, et al. which reported that the authors conducted a genome-wide analysis of DNA methylation of the tumor and non-tumor tissue of 15 patients with Hepatocellular carcinoma (HCC), and revealed TBX15 was the most hypermethylated gene of the tumor.

25 Jan 2021

Experts advise disaggregating data on COVID-19 patients by sex

Researchers at Yale University School of Medicine have highlighted the importance of ensuring studies of patients with coronavirus disease 2019 (COVID-19) report data in a sex-disaggregated manner.

24 Jan 2021

UC research team uses zebrafish to study a gene mutation that causes congenital scoliosis

Popular in aquariums all over the world, the zebrafish is native to South Asia. But here in a Cincinnati Children's laboratory, the freshwater variant plays a vital role in scientific discovery.

22 Jan 2021

National consortium to study the effects of emerging SARS-CoV-2 mutations

A new national research project to study the effects of emerging mutations in SARS-CoV-2 will be launched with £2.5 million of funding from UK Research and Innovation.

15 Jan 2021

Scientists identify animal model to study human musculoskeletal aging

There are many components to aging, both mental and physical. When it comes to the infrastructure of the human body - the musculoskeletal system that includes muscles, bones, tendons and cartilage - age-associated decline is inevitable, and the rate of that decline increases the older we get.

14 Jan 2021

New taxonomic classification of non-skeletal rare congenital disorders with impact on bone physiology

Thanks to major progress in the understanding and management of rare congenital diseases and syndromes, many patients with these rare disorders are now living longer lives.

13 Jan 2021

Study finds association between severity of COVID-19 and shorter telomeres

Patients with severe COVID-19 disease have significantly shorter telomeres, according to a study conducted by researchers at the Spanish National Cancer Research Centre in collaboration with the COVID-IFEMA Field Hospital, published in the journal Aging.

11 Jan 2021

Vanderbilt researcher proposes an explanatory paradigm for the cause of autism

A unifying explanation of the cause of autism and the reason for its rising prevalence has eluded scientists for decades, but a theoretical model published in the journal Medical Hypotheses describes the cause as a combination of socially valued traits, common in autism, and any number of co-occurring disabilities.

8 Jan 2021

ACE2 receptor is responsible for the wide host range of SARS-CoV-2

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is thought to have a zoonotic origin, perhaps originating in a bat coronavirus with an unknown intermediate host. It is not only very infectious but has been found to infect a wide range of mammals, including dogs, cats, ferrets, hamsters, and minks, besides non-human primates. This range may be still higher, claims a recent preprint that appeared in January 2021 on the bioRxiv server.

6 Jan 2021

Scientist receives $1.37 million grant to advance metabolomics data

The National Institutes of Health (NIH) has awarded University of Massachusetts Amherst biostatistician Raji Balasubramanian a four-year, $1.37 million grant to advance the analysis of data from metabolomics research.

5 Jan 2021

SARS-CoV-2 infected alveolar type-II lung cells show senescence

Using monoclonal antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein and senescent markers, researchers provide evidence that virus-infected lung cells acquire characteristics of cellular senescence, which also leads to expression of proinflammatory cytokines.

5 Jan 2021

Researchers develop a gene signature for predicting survival in patients with peritoneal carcinomatosis

Researchers from The University of Texas MD Anderson Cancer Center who profiled more than 45,000 individual cells from patients with peritoneal carcinomatosis (PC), a specific form of metastatic gastric cancer, defined the extensive cellular heterogeneity and identified two distinct subtypes correlated with patient survival.

4 Jan 2021

Sustained immune dysregulation due to COVID-19 in non-hospitalized patients

COVID-19, which has killed 1.7 million people worldwide, does not follow a uniform path.

29 Dec 2020

Phenotype News and Research

RPS-12 protein overproduction appears to trigger breast cancer and other malignancies

Researchers explore adaptive immunity against human coronaviruses

Study finds protective genetic associations with mild COVID-19

Genomic studies give new insights into the biological basis of PTSD

New compound may slow aging and age-related diseases

Study shows why children of obese mothers have propensity to develop metabolic diseases

Circulating antiphospholipid antibodies drive endothelial cell activation in COVID-19

Reduced expression of TBX15 in tumor tissue represents a prognostic biomarker for HCC patients

Experts advise disaggregating data on COVID-19 patients by sex

UC research team uses zebrafish to study a gene mutation that causes congenital scoliosis

National consortium to study the effects of emerging SARS-CoV-2 mutations

Scientists identify animal model to study human musculoskeletal aging

New taxonomic classification of non-skeletal rare congenital disorders with impact on bone physiology

Study finds association between severity of COVID-19 and shorter telomeres

Vanderbilt researcher proposes an explanatory paradigm for the cause of autism

ACE2 receptor is responsible for the wide host range of SARS-CoV-2

Scientist receives $1.37 million grant to advance metabolomics data

SARS-CoV-2 infected alveolar type-II lung cells show senescence

Researchers develop a gene signature for predicting survival in patients with peritoneal carcinomatosis

Sustained immune dysregulation due to COVID-19 in non-hospitalized patients

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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