Phenotype News and Research

RSS

Exploring the role of the metabolic syndrome in individual mechanisms of liver fibrosis

Chronic liver injury results in the development of liver fibrosis in approximately 25% of individuals in response to diverse insults, and several aspects of the development of liver injury appear to be common to a variety of initiating factors.

31 Aug 2023

Study finds semaglutide provides benefits for patients with obesity phenotype of heart failure and HFpEF

Researchers evaluated the efficacy of semaglutide in patients with the obesity phenotype of heart failure and preserved ejection fraction.

31 Aug 2023

Innovative insights into effects of hematopoietic changes on colon cancer, unveiling therapeutic avenues

Researchers investigated whether bone marrow-derived cells contribute to colitis-associated colon cancer.

29 Aug 2023

Beyond health records: Deep learning enhances disease diagnosis via image-based phenotyping

Researchers explored the use of image-based phenotyping based on dual-energy X-ray absorptiometry (DXA) scans.

28 Aug 2023

Semaglutide could be a game-changer for patients with HFpEF and obesity

Semaglutide improves heart failure-related symptoms and physical function and results in greater weight loss compared with placebo in patients with heart failure with preserved ejection fraction (HFpEF) and obesity, according to late-breaking research presented in a Hot Line session today at ESC Congress 2023.

25 Aug 2023

Age-related changes in the blood system can exacerbate colon cancer

Researchers at the University of Florida College of Medicine have discovered how common age-related changes in the blood system can make certain colon cancers grow faster.

24 Aug 2023

The value of whole-exome sequencing as a first-tier genetic test in the diagnosis of skin disorders

The genetic etiology by whole-exome sequencing (WES).

23 Aug 2023

New insights into the pathogenic mechanisms of SLC29A3 disorders

In humans, the SLC29A3 gene regulates the function of lysosomes to control waste recycling in cells such as macrophages (that engulf and destroy foreign bodies).

22 Aug 2023

The relationship between breast milk feeding and infants’ neurodevelopment via epigenetics

Researchers collated studies on the epigenetic advantages of breast milk feeding and neurodevelopment in infants.

22 Aug 2023

Machine learning-based preeclampsia risk prediction

Study developed a machine-learning-based model using the Medical Record Longitudinal Information AI System (MERLIN).

21 Aug 2023

The interplay between the microbiota, the epigenome, and nutrition among obese adults during behavioral weight reduction

Study evaluated associations between gut microbiome (MB), deoxyribonucleic acid (DNA) methylation (DNAme), and nutrition.

21 Aug 2023

Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling

Researchers describe molecular signalling regulated by mTOR among memory and exhausted cytotoxic CD8+ T lymphocytes.

18 Aug 2023

Interactomics-based analysis suggests that rhinitis and rhinitis with asthma are mechanistically different diseases

Researchers used human transcriptomic data to differentiate the molecular mechanisms associated with two phenotypes of allergic rhinitis: rhinitis and rhinitis with asthma.

17 Aug 2023

Copy number profiling provides insight as to why prostate cancer may become lethal

Researchers performed genome-wide copy number profiling of the androgen receptor (AR) on metastases from deceased prostate cancer patients.

16 Aug 2023

Study shows how brain rhythms can affect brain function by altering microglia and cytokines

Researchers used visual flickering sensory stimulation to reveal the underlying mechanisms governing microglial morphology and cytokine expression in mice.

16 Aug 2023

Newly discovered protein kinase shows promise for establishing future obesity and diabetes treatments

Researchers used genetically modified animal models to investigate the role of the newly discovered Traf2- and NCK-interacting protein kinase (TNIK) in obesity and metabolic dysfunction.

15 Aug 2023

UAB researchers identify cell-surface marker that indicates fate of T cells

Follicular helper T cells, or Tfh cells, have a crucial role in immune defense. Without Tfh cells, B cells cannot form germinal center, or GC, responses during which high-affinity antibodies are generated.

14 Aug 2023

Transparent crystal ribcage for real-time imaging of lung function

Researchers develop the ‘crystal ribcage,’ a transparent ribcage for real-time lung imaging at cellular resolution.

14 Aug 2023

Novel multi-epitope subunit vaccine induces robust immune response against Epstein-Barr virus

Scientists have developed a lymph node-targeted multi-epitope subunit vaccine that induces strong humoral and cellular immune responses against EBV in mice.

14 Aug 2023

New insights into severe obesity genetics: Evidence from adults seeking treatment reveals intriguing oligogenic patterns

Researchers explore the prevalence of rare genetic forms of obesity in a United Kingdom-based clinical obesity cohort.

14 Aug 2023

Phenotype News and Research

Exploring the role of the metabolic syndrome in individual mechanisms of liver fibrosis

Study finds semaglutide provides benefits for patients with obesity phenotype of heart failure and HFpEF

Innovative insights into effects of hematopoietic changes on colon cancer, unveiling therapeutic avenues

Beyond health records: Deep learning enhances disease diagnosis via image-based phenotyping

Semaglutide could be a game-changer for patients with HFpEF and obesity

Age-related changes in the blood system can exacerbate colon cancer

The value of whole-exome sequencing as a first-tier genetic test in the diagnosis of skin disorders

New insights into the pathogenic mechanisms of SLC29A3 disorders

The relationship between breast milk feeding and infants’ neurodevelopment via epigenetics

Machine learning-based preeclampsia risk prediction

The interplay between the microbiota, the epigenome, and nutrition among obese adults during behavioral weight reduction

Regulation of cytotoxic T-cell differentiation and exhaustion by mTOR signaling

Interactomics-based analysis suggests that rhinitis and rhinitis with asthma are mechanistically different diseases

Copy number profiling provides insight as to why prostate cancer may become lethal

Study shows how brain rhythms can affect brain function by altering microglia and cytokines

Newly discovered protein kinase shows promise for establishing future obesity and diabetes treatments

UAB researchers identify cell-surface marker that indicates fate of T cells

Transparent crystal ribcage for real-time imaging of lung function

Novel multi-epitope subunit vaccine induces robust immune response against Epstein-Barr virus

New insights into severe obesity genetics: Evidence from adults seeking treatment reveals intriguing oligogenic patterns

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Latest News