Phenotype News and Research

RSS

Study reveals that composition of skin microbiota is controlled by host genome

Numerous recent studies linked gut microbiota with various diseases such as obesity or diabetes. Little is known, however, on how gut and skin microbiota composition is controlled.

18 Sep 2013

Planarian flatworm: An ideal model to study molecular basis of regeneration

Unlike humans, planarian flatworms have the remarkable ability to regrow any missing body part, making them an ideal model with which to study the molecular basis of regeneration.

5 Sep 2013

65 metabolites in urine simultaneously measured by clinical IEM-by-NMR screening study in Turkey

At the 12th International Congress of Inborn Errors of Metabolism (www.iciem2013.com), Bruker announces another milestone in the cost-effective use of NMR (nuclear magnetic resonance) spectroscopy screening as a clinical research tool for metabolic screening and small molecule in vitro diagnostics (IVD) research and validation.

4 Sep 2013

Argininosuccinic aciduria (ASA) and gene therapy: an interview with Dr Julien Baruteau, UCL Institute for Women's Health, London

This rare genetic condition can theoretically affect patients at any age but symptoms are more often observed in childhood and even uncommonly during the first days of life.

2 Sep 2013

Research reveals that only 7% of patients survive from out-of-hospital cardiac arrest

Survival for out-of-hospital cardiac arrest is just 7%, according to research presented at ESC Congress 2013 by Professor Xavier Jouven and Dr Wulfran Bougouin from France.

2 Sep 2013

Absence or presence of single protein can make cancer cells more or less susceptible to drugs

A new weakness has been discovered in cancer cells that may make them more susceptible to chemotherapy and other treatments. In a research report appearing in the September 2013 issue of The FASEB Journal, scientists identify the HDAC5 protein as being essential for the maintenance of structures, called telomeres, within cancer cells that promote cancer cells longevity.

30 Aug 2013

MC1R mutation responsible for red hair phenotype also promotes cancer-causing pathway

A person's skin pigment, which determines hair color and skin tone, is influenced by the melanocortin-1 (MC1R) gene receptor. For the population's one to two percent of redheads, a mutation in MC1R accounts for their red hair color and typical light skin.

23 Aug 2013

Research links high prevalence of Type 2 diabetes in the American South with economic conditions

The strikingly high prevalence of Type 2 diabetes in the American South can be partially traced to rapid economic growth between 1950 and 1980, new research suggests.

6 Aug 2013

New finding suggests potential to improve safety, performance of reprogrammed cells

The enormous promise of regenerative medicine is matched by equally enormous challenges. But a new finding by a team of researchers led by Weill Cornell Medical College has the potential to improve both the safety and performance of reprogrammed cells.

2 Aug 2013

Genetics could help women at risk of developing gestational diabetes

New Northwestern Medicine- research on the genetics of diabetes could one day help women know their risk for developing gestational diabetes before they become pregnant -- and lead to preventive measures to protect the health of offspring.

1 Aug 2013

ADC Therapeutics, BZL Biologics sign licensing deal for antibody against PSMA-positive prostate cancers

ADC Therapeutics Sarl, a portfolio company of Auven Therapeutics and the oncology drug development company specializing in proprietary antibody drug conjugates, and BZL Biologics LLC, of New York, today announced an exclusive licensing and collaboration agreement for an antibody against PSMA-positive prostate cancers.

15 Jul 2013

High folate intake during pregnancy may have undiscovered later-life effect in progeny

During pregnancy, women are normally advised to take high amounts of multivitamin supplements. In particular, folate is recommended to reduce the risk of neural tube defects in newborns. The problem is that, although vitamins are critical in fetal development, high vitamin doses during pregnancy may cause undesired effects on the offspring later in life.

15 Jul 2013

New theory challenges orthodox view that cancer develops in each host by mutational accidents

A new way to look at cancer -- by tracing its deep evolutionary roots to the dawn of multicellularity more than a billion years ago -- has been proposed by Paul Davies of Arizona State University's Beyond Center for Fundamental Concepts in Science in collaboration with Charles Lineweaver of the Australian National University.

15 Jul 2013

Researchers discover potential biomarkers that track progression of neurodegenerative disease

A hallmark of neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's is that by the time symptoms appear, significant brain damage has already occurred-and currently there are no treatments that can reverse it.

9 Jul 2013

Scientists focus on the role of mutated adult neural stem cells play in human diseases

CHARGE syndrome* is a severe developmental disorder affecting multiple organs. It affects 1 in 8500 newborns worldwide. The majority of patients carry a mutation in a gene called CHD7. How this single mutation leads to the broad spectrum of characteristic CHARGE symptoms has been a mystery.

6 Jul 2013

Alnylam Pharmaceuticals presents new pre-clinical data of ALN-AT3 at ISTH meeting

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has presented new pre-clinical data from its RNAi therapeutic program for the treatment of hemophilia and rare bleeding disorders.

2 Jul 2013

Study: Individuals with ASDs show decrease metabolism of amino acid L-tryptophan

Researchers at the JC Self Research Institute of the Greenwood Genetic Center (GGC), along with collaborators from Biolog, Inc. in California, have reported an important discovery in the understanding of autism which was published this week in Molecular Autism.

7 Jun 2013

Study brings researchers one step closer to personalized colorectal cancer treatment

MET protein levels correlate strongly with epithelial-mesenchymal transition phenotype, a treatment-resistant type of colorectal cancer and may be used as a surrogate biomarker, according to new research from The University of Texas MD Anderson Cancer Center.

4 Jun 2013

International researchers find how brain cancer cells survive and drive tumor growth

An international team of researchers - led by principal investigator Paul S. Mischel, MD, a member of the Ludwig Institute for Cancer Research and professor in the Department of Pathology at the University of California, San Diego School of Medicine - has found that a singular gene mutation helps brain cancer cells to not just survive, but grow tumors rapidly by altering the splicing of genes that control cellular metabolism.

1 Jun 2013

Potential new treatment approaches for liver diseases

By discovering the new mechanism by which estrogen suppresses lipid synthesis in the liver, UC Irvine endocrinologists have revealed a potential new approach toward treating certain liver diseases.

24 May 2013

Phenotype News and Research

Study reveals that composition of skin microbiota is controlled by host genome

Planarian flatworm: An ideal model to study molecular basis of regeneration

65 metabolites in urine simultaneously measured by clinical IEM-by-NMR screening study in Turkey

Argininosuccinic aciduria (ASA) and gene therapy: an interview with Dr Julien Baruteau, UCL Institute for Women's Health, London

Research reveals that only 7% of patients survive from out-of-hospital cardiac arrest

Absence or presence of single protein can make cancer cells more or less susceptible to drugs

MC1R mutation responsible for red hair phenotype also promotes cancer-causing pathway

Research links high prevalence of Type 2 diabetes in the American South with economic conditions

New finding suggests potential to improve safety, performance of reprogrammed cells

Genetics could help women at risk of developing gestational diabetes

ADC Therapeutics, BZL Biologics sign licensing deal for antibody against PSMA-positive prostate cancers

High folate intake during pregnancy may have undiscovered later-life effect in progeny

New theory challenges orthodox view that cancer develops in each host by mutational accidents

Researchers discover potential biomarkers that track progression of neurodegenerative disease

Scientists focus on the role of mutated adult neural stem cells play in human diseases

Alnylam Pharmaceuticals presents new pre-clinical data of ALN-AT3 at ISTH meeting

Study: Individuals with ASDs show decrease metabolism of amino acid L-tryptophan

Study brings researchers one step closer to personalized colorectal cancer treatment

International researchers find how brain cancer cells survive and drive tumor growth

Potential new treatment approaches for liver diseases

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Latest News