Phenotype News and Research

RSS

COPD patients with allergic phenotype have increased risk of lower respiratory symptoms, exacerbations

Patients with chronic obstructive pulmonary disease (COPD) who also have allergic disease have higher levels of respiratory symptoms and are at higher risk for COPD exacerbations, according to a new study from researchers at Johns Hopkins University in Baltimore.

10 May 2013

Scientists identify new class of immune cells that suppress genital herpes

Fred Hutchinson Cancer Research Center and University of Washington scientists have identified a class of immune cells that reside long-term in the genital skin and mucosa and are believed to be responsible for suppressing recurring outbreaks of genital herpes.

9 May 2013

TBI in older adults presents special diagnostic, management and treatment challenges

Each year more than 1.7 million people in the United States sustain a traumatic brain injury (TBI). The incidence of TBI in older adults poses special diagnostic, management and treatment challenges, say experts in a special collection of papers on TBI in the elderly in NeuroRehabilitation: An Interdisciplinary Journal.

7 May 2013

COPD-asthma overlap ‘needs greater recognition’

More attention should be given to patients who have chronic obstructive pulmonary disease and concomitant asthma, after a study showed that nearly one-fifth of patients with COPD fall into this subtype.

30 Apr 2013

Epstein–Barr virus linked to improved gastric cancer survival

Research shows that Epstein–Barr virus positivity in gastric tumor cells is associated with improved prognosis.

25 Apr 2013

Research supports polygenic phenotype in schizophrenia

Cumulative genetic risk for schizophrenia has been linked to impaired prefrontal brain activity, in findings that support an additive genetic risk model for a polygenic phenotype.

25 Apr 2013

Studies examine existing opportunity to improve interventions, outcomes of TBI in older adults

Considerable opportunity exists to improve interventions and outcomes of traumatic brain injury in older adults, according to three studies published in the recent online issue of NeuroRehabilitation by researchers from the Icahn School of Medicine at Mount Sinai.

30 Mar 2013

Online database is speeding the search for diseases caused by rogue gene

A new online database combining symptoms, family history and genetic sequencing information is speeding the search for diseases caused by a single rogue gene.

20 Mar 2013

Study: Intake of carbohydrate-enriched foods after birth predisposes child to obesity later in life

Consumption of foods high in carbohydrates immediately after birth programs individuals for lifelong increased weight gain and obesity, a University at Buffalo animal study has found, even if caloric intake is restricted in adulthood for a period of time.

20 Mar 2013

New research project on systems biology of synapse proteins and ageing launched

The AgedBrainSYSBIO project on systems biology of synapse proteins & ageing was officially launched March18th in Paris, France.

20 Mar 2013

Study on neoadjuvant cisplatin-based chemotherapy presented at 28th Annual EAU Congress

At the 28th Annual EAU Congress currently ongoing in Milan until Tuesday, W. Tan and colleagues presented their study on neoadjuvant cisplatin-based chemotherapy which showed that epigenetic changes are potential key drivers in the development of chemo resistance in bladder cancer.

18 Mar 2013

Columbia University Medical Center, NewYork-Presbyterian Hospital present research works at AAN meeting

The following research from Columbia University Medical Center and NewYork-Presbyterian Hospital is being presented at the 65th annual meeting of the American Academy of Neurology, March 16-23, 2013, in San Diego.

18 Mar 2013

Long-term treatment with spironolactone improves left ventricular diastolic function in HF patients

Among patients with heart failure with preserved ejection fraction, long-term treatment with the medication spironolactone improved left ventricular diastolic function but did not affect maximal exercise capacity, patient symptoms, or quality of life, according to a study appearing in the February 27 issue of JAMA.

28 Feb 2013

Two discriminating biological markers found to predict a favorable response to treatment in triple-negative breast cancer

Quinten, a strategic and operational consulting company specializing in the evaluation of biomedical data in the pharmaceutical, biotechnology and cosmetic industries, today announces the identification of two discriminating biological marker candidates which are indicative of a favorable response to treatment in women suffering from triple-negative breast cancer (TNBC).

26 Feb 2013

Genetic testing strategy for familial high cholesterol questioned

Current testing strategies for the families of patients with familial hypercholesterolemia may not be an efficient use of health resources, suggest study results published in The Lancet.

25 Feb 2013

Adolescent bipolar disorder ‘does not conform to checklist’

Young people with bipolar disorder who are in a depressive episode do not conform to the child behavior checklist–juvenile bipolar disorder phenotype profile, the results of a US study indicate.

25 Feb 2013

Severe childhood asthma blood test hopes dashed

Blood eosinophil counts do not reliably reflect airway eosinophil concentrations in children with severe, therapy-resistant asthma, and therefore cannot be used to make therapeutic decisions, researchers report.

19 Feb 2013

Study describes pharmacological action of TZDs directly on pancreas

A scientific study published on the journal Diabetes, edited by the American Diabetes Association, describes for the first time the pharmacological action of thiazolidinediones (TZDs) —anti-diabetic drugs— directly on pancreas, the organ which produces insulin.

18 Feb 2013

Researchers explore cellular signals produced by the body in response to traumatic injury

When it comes to healing the terrible wounds of war, success may hinge on the first blood clot - the one that begins forming on the battlefield right after an injury. Researchers exploring the complex stream of cellular signals produced by the body in response to a traumatic injury believe the initial response - formation of a blood clot - may control subsequent healing.

18 Feb 2013

Stress and mental illness: an interview with Professor Akira Sawa

As a psychiatrist I am interested in how stress may play a role in the pathology of adult mental disorders. You may know that most of the major mental illnesses, such as schizophrenia, mood-disorder, substance abuse or even anxiety disorder, become prominent in early adulthood.

14 Feb 2013

Phenotype News and Research

COPD patients with allergic phenotype have increased risk of lower respiratory symptoms, exacerbations

Scientists identify new class of immune cells that suppress genital herpes

TBI in older adults presents special diagnostic, management and treatment challenges

COPD-asthma overlap ‘needs greater recognition’

Epstein–Barr virus linked to improved gastric cancer survival

Research supports polygenic phenotype in schizophrenia

Studies examine existing opportunity to improve interventions, outcomes of TBI in older adults

Online database is speeding the search for diseases caused by rogue gene

Study: Intake of carbohydrate-enriched foods after birth predisposes child to obesity later in life

New research project on systems biology of synapse proteins and ageing launched

Study on neoadjuvant cisplatin-based chemotherapy presented at 28th Annual EAU Congress

Columbia University Medical Center, NewYork-Presbyterian Hospital present research works at AAN meeting

Long-term treatment with spironolactone improves left ventricular diastolic function in HF patients

Two discriminating biological markers found to predict a favorable response to treatment in triple-negative breast cancer

Genetic testing strategy for familial high cholesterol questioned

Adolescent bipolar disorder ‘does not conform to checklist’

Severe childhood asthma blood test hopes dashed

Study describes pharmacological action of TZDs directly on pancreas

Researchers explore cellular signals produced by the body in response to traumatic injury

Stress and mental illness: an interview with Professor Akira Sawa

Achieving and maintaining ISO 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

Latest News